Vasospastischer Verschluss der Arteria femoralis superficialis nach chronischem Ergotaminkonsum

Bogun, N; Mathies, R; Bäsecke, Jörg

doi:10.1055/s-0030-1269435

Dtsch med Wochenschr

2010

DOI: 10.1055/s-0030-1269435

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Vasospastischer Verschluss der Arteria femoralis superficialis nach chronischem Ergotaminkonsum

N Bogun¹,

R Mathies²,

Jörg Bäsecke³

Abstract: Nowadays iatrogenic ergotism of the limbs is a rare diagnosis. An exact medical history and typical duplex sonographic findings confirm the diagnosis even if characteristic risk factors are missing. The first therapeutic measure in case of claudication is for ergotamine to be stopped. In case of critical ischaemia or gangrene immediate vasodilator therapy, e. g. with prostaglandine E1, is indicated.

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Conradt

2019

Endo-Praxis

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ZusammenfassungPatienten mit unterschiedlichen Ursachen einer Schluckstörung gehören heute zu unserem Klinikalltag. Die Anlage einer perkutanen Ernährungssonde ist für viele der Betroffenen eine technisch einfache, standardisierte und effektive Möglichkeit der künstlichen Ernährung. Unterschiedliche Perspektiven beteiligter Personen und Entscheidungsträger zur Sinnhaftigkeit und Indikation führen dennoch häufig zu Konfliktsituationen. Umso wichtiger in der patientenorientierten Indikationsstellung werden somit medizinische, ethische und gesetzliche Aspekte. Deren Beachtung und eine gute Kommunikation können dazu beitragen, unnötige Konflikte zu vermeiden.

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Scientific Opinion on Ergot alkaloids in food and feed

2012

EFS2

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The European Food Safety Authority (EFSA) was asked by the European Commission to deliver a scientific opinion on ergot alkaloids (EAs) in food and feed. EAs are produced by several members within the fungal orders of Hypocreales and Eurotiales. In Europe, Claviceps purpurea is the most widespread Claviceps species within the Hypocreales. A total of 20 558 analytical results for EAs in 1 716 food, 496 feed and 67 unprocessed grain samples were considered in this opinion. Based on the EAs identified in sclerotia of C. purpurea, and recent literature data, the EFSA Panel on Contaminants in the Food Chain (CONTAM Panel) based its risk assessment on the main C. purpurea EAs, namely ergometrine, ergotamine, ergosine, ergocristine, ergocryptine (which is a mixture of α- and β- isomers), ergocornine, and the corresponding –inine epimers. The CONTAM Panel performed estimates of both chronic and acute exposure for various age groups across European countries. A BMDL10 of 0.33 mg/kg b.w. per day was calculated for the incidence of tail muscular atrophy in a 13-week rat feeding study of ergotamine. This effect was considered representative of the vasoconstrictive effects of EAs and provided a suitable reference point for establishment of a group acute reference dose of 1 μg/kg body weight (b.w.) and a group tolerable daily intake of 0.6 μg/kg b.w. per day. The Panel concluded that whilst the available data do not indicate a concern for any population subgroup, the dietary exposure estimates relate to a limited number of food groups and a possible unknown contribution from other foods cannot be discounted. Estimates of exposure for livestock based on example diets and levels of EAs in cereal grains reported suggest that under normal conditions the risk of toxicosis is low.

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Vasospastischer Verschluss der Arteria femoralis superficialis nach chronischem Ergotaminkonsum

Cited by 2 publications

References 4 publications

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Scientific Opinion on Ergot alkaloids in food and feed

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