Vasospastic angina pectoris associated with Churg–Strauss syndrome

Abstract

Treatment with systemic corticosteroids and cyclophosphamide.

Acute Coronary Syndrome Caused by Coronary Vasospasms Associated with Churg-Strauss Syndrome: Effects of Betamethasone Therapy

“…Although coronary vasospasms are an unusual clinical manifestation of CSS, the present case suggests that coronary vasospasms should be suspected in cases of CSS. In one CSS patient with recurrent episodes of unstable angina pectoris, the intracoronary infusion of acetylcholine induced multiple coronary artery spasms (2). In that patient, coronary angiography showed no anatomic stenosis before the infusion of intracoronary acetylcholine.…”

“…Several reports have suggested a possible link between numerous types of allergic diseases and coronary vasospasms (2,3,14). The reported patients were refractory to vasodilator treatment but successfully treated with immunosuppressive therapy.…”

“…Although the overall prognosis is good, clinical studies suggest that cardiac involvement is associated with an adverse prognosis (1). The cardiac manifestations of CSS vary, including myocarditis, congestive heart failure and valvular disease, while coronary vasospasms are rare (2,3). We herein report the case of a woman who presented with acute coronary syndrome caused by coronary vasospasms.…”

Eosinophilia and Coronary Artery Vasospasm

“…The indication for prednisone was often an exacerbation of asthma and in these cases prednisone was usually stopped after several weeks. Recurrent coronary events are summarised in Table 2 cyclophosphamide [24]. Another patient had angina and elevation of ST segment on the electrocardiogram while taking prednisone for Eosinophilia-myalgia syndrome [14].…”

“…This usually showed spontaneous or provoked multi-focal vasospasm, but in different segments of the coronary arteries and with resolution of previous stenoses. One patient had multi-focal vasospasm induced by acetylcholine on the index angiogram, but after six months of prednisone the coronary arteries appeared normal and there was no vasospasm after intra-coronary acetylcholine [24].…”