Vasospastic angina induced by prostaglandin F2 alpha.

The Comparative Cardiovascular, Pulmonary, Ocular Blood Flow, and Ocular Hypotensive Effects of Topical Travoprost, Bimatoprost, Brimonidine, and Betaxolol

“…In previously reported long-term studies, no significant differences from baseline were noted for heart rate, systolic, or diastolic blood pressure with bimatoprost and travoprost treatment (10,28). However, intravenous infusion of PGF 2␣ given for postoperative paralytic ileus was reported to cause coronary artery spasm in a 56-year-old woman (35). Our study reflects the short-term effects of travoprost and bimatoprost on cardiovascular parameters in healthy subjects.…”

Cessation of migraines in a woman with low-tension glaucoma following the use of latanoprost: a favourable side effect?

“…4 Systemic use of prostaglandin F 2a has been implicated in cardiac arrhythmias and vasospastic angina. 4,11 Sumatriptan, the most extensively investigated antimigraine drug, 7 is a known vasoconstrictor. Although the plasma half-life of local applied latanoprost is short we postulate that the main mechanism that may have caused cessation of the migraines is via a slight systemic vasoconstriction.…”