Vasorelaxing effect and possible chemical markers of the flowers of the Mexican <i>Crataegus gracilior</i>

Torres-Ortiz, Daniela Alejandra; Eloy, Rodríguez-deLeón; Bah, Moustapha; Ibarra‐Alvarado, César; Edmundo, Mercado-Silva; Eduardo, Castro-Ruiz Jesús; María, Rivera-Pastrana Dulce

doi:10.1080/14786419.2019.1577833

Cited by 8 publications

(5 citation statements)

References 9 publications

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“…PCTs can be found in the aerial parts, stems, and resin of the identified plants, which must be dried and milled prior to the extraction procedures. Usually, for extraction, organic solvents are used for the extract preparation as binary mixtures, dichloromethane (CH 2 Cl 2 ), hexane (C 6 H 14 ), chloroform (CHCl 3 ), and methyl alcohol (CH 3 OH) are the most adopted solvents [31,[35][36][37][38]41,50]. The main extraction techniques used for PCTs from Mexican plants are maceration and Soxhlet extraction [30,37,39,47].…”

Section: Extraction and Purification Methodsmentioning

confidence: 99%

“…Additionally, methanolic extract of flowers from Crataegeus gracilior presented vasorelaxant effects on rat aortic rings [50]. The extract had an EC 50 of 1.83 ± 1.39 µg/mL and an E max of 100 ± 3.4%, being 5-fold more potent than the positive control acetylcholine (ACh) (EC 50 of 9.77 ± 0.81 µg/mL and an E max of 66.72 ± 1.07%).…”

Section: Biological Activity Survey Of Pcts Found In Mexican Plantsmentioning

confidence: 99%

“…50 ) on G. intestinalis: 0.11 µMTingenoneFriedelane Antiprotozoal activity (IC 50 ) on G. intestinalis: 0.74 µM…”

mentioning

confidence: 99%

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State-of-the-Art and Opportunities for Bioactive Pentacyclic Triterpenes from Native Mexican Plants

Alfaro-Almaguer

Mejía‐Manzano

González‐Valdez

2022

Plants

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Native Mexican plants are a wide source of bioactive compounds such as pentacyclic triterpenes. Pentacyclic triterpenes biosynthesized through the mevalonate (MVA) and the 2-C-methyl-D-erythritol-phosphate (MEP) metabolic pathways are highlighted by their diverse biological activity. Compounds belonging to the oleanane, ursane, and lupane groups have been identified in about 33 Mexican plants, located geographically in the southwest of Mexico. The works addressing these findings have reported 45 compounds that mainly show antimicrobial activity, followed by anti-inflammatory, cytotoxic, anxiolytic, hypoglycemic, and growth-stimulating or allelopathic activities. Extraction by maceration and Soxhlet with organic solvents and consecutive chromatography of silica gel have been used for their whole or partial purification. Nanoparticles and nanoemulsions are the vehicles used in Mexican formulations for drug delivery of the pentacyclic triterpenes until now. Sustainable extraction, formulation, regulation, isolation, characterization, and bioassay facilities are areas of opportunity in pentacyclic triterpenes research in Mexico while the presence of plant and human resources and traditional knowledge are strengths. The present review discusses the generalities of the pentacyclic triterpene (definition, biogenic classification, and biosynthesis), a summary of the last two decades of research on the compounds identified and their evaluated bioactivity, the generalities about the extraction and purification methods used, drug delivery aspects, and a critical analysis of the advantages and limitations of research carried out in this way.

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Section: Extraction and Purification Methodsmentioning

confidence: 99%

Section: Biological Activity Survey Of Pcts Found In Mexican Plantsmentioning

confidence: 99%

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State-of-the-Art and Opportunities for Bioactive Pentacyclic Triterpenes from Native Mexican Plants

Alfaro-Almaguer

Mejía‐Manzano

González‐Valdez

2022

Plants

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“…They showed that the extract possessed a concentration-dependent vasodilator property, and the authors suggested that the main agent responsible for that activity was CO. However, contributions of other flavonoids and triterpenes could not be excluded [88].…”

Section: Corosolic Acidmentioning

confidence: 99%

Beneficial Effects of Ursolic Acid and Its Derivatives—Focus on Potential Biochemical Mechanisms in Cardiovascular Conditions

2021

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Ursolic acid (UA) is a natural pentacyclic triterpenoid found in a number of plants such as apples, thyme, oregano, hawthorn and others. Several in vitro and in vivo studies have presented its anti-inflammatory and anti-apoptotic properties. The inhibition of NF-κB-mediated inflammatory pathways and the increased scavenging of reactive oxygen species (ROS) in numerous ways seem to be the most beneficial effects of UA. In mice and rats, administration of UA appears to slow down the development of cardiovascular diseases (CVDs), especially atherosclerosis and cardiac fibrosis. Upregulation of endothelial-type nitric oxide synthase (eNOS) and cystathionine-λ-lyase (CSE) by UA may suggest its vasorelaxant property. Inhibition of metalloproteinases activity by UA may contribute to better outcomes in aneurysms management. UA influence on lipid and glucose metabolism remains inconsistent, and additional studies are essential to verify its efficacy. Furthermore, UA derivatives appear to have a beneficial impact on the cardiovascular system. This review aims to summarize recent findings on beneficial effects of UA that may make it a promising candidate for clinical trials for the management of CVDs.

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“…Regarding the chemical composition of Mexican Crataegus species, chlorogenic acid, (+)-catechin, (-)-catechin, quercetin, kaempferol and apigenin glycosides have been identified in the ethanolic extracts obtained from the fruits of C. stipulosa , C. mexicana , C. nelsoni ( García-Mateos et al, 2013 ) and C. pubescens ( González-Jiménez et al, 2018 ) . Additionally, ursolic, corosolic and euscapic acids have been identified in the methanolic extracts obtained from the leaves and flowers of C. gracilior ( Hernández-Pérez et al, 2014 , Torres-Ortiz et al, 2019 ). Both extracts showed antioxidant effect and elicited a significant vasodilator activity.…”

Section: Introductionmentioning

confidence: 99%

Development of a quantified herbal extract of hawthorn Crataegus mexicana leaves with vasodilator effect

Ornelas-Lim

Luna-Vázquez

Rojas‐Molina

et al. 2021

Saudi Pharmaceutical Journal

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Hawthorn ( Crataegus spp .) has been used for the treatment of several heart diseases and hypertension. The studies carried out on several hawthorn species have led to the development of standardized extracts useful in the cure of mild chronic cardiac diseases. In Mexico, the most common Crataegus species are C. mexicana and C. gracilior . Decoctions prepared from the fruits and leaves of these species have been employed to the treat respiratory diseases, tachycardia and to improve coronary blood flow. Considering that to date there are no reports of the use of Mexican Crataegus species to treat cardiovascular diseases, we propose an analytical method to obtain a quantified extract of Crataegus mexicana leaves for the development of a standardized extract with therapeutic value in cardiovascular diseases as an alternative source to the extracts obtained from Crataegus species of European and Asian origin. Therefore, the aim of this study was to obtain an extract prepared from C. mexicana leaves with the highest vasodilator activity to select the optimal chemical marker to stablish and validate a reversed-phase high-performance liquid chromatography (RPHPLC-DAD) analytical method for obtaining a quantified extract with vasodilator effect. The results obtained from the analytical method validation, which was carried out according to the guidelines stablished in the Eurachem Guide and the ICH guidelines proved that the RPHPLC-DAD method we developed was specific, precise, accurate, and showed good linearity over the concentration range of 3 – 21 µg/ml for (-)-epicatechin and rutin, which were selected as chemical markers.

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Vasorelaxing effect and possible chemical markers of the flowers of the Mexican Crataegus gracilior

Cited by 8 publications

References 9 publications

State-of-the-Art and Opportunities for Bioactive Pentacyclic Triterpenes from Native Mexican Plants

State-of-the-Art and Opportunities for Bioactive Pentacyclic Triterpenes from Native Mexican Plants

Beneficial Effects of Ursolic Acid and Its Derivatives—Focus on Potential Biochemical Mechanisms in Cardiovascular Conditions

Development of a quantified herbal extract of hawthorn Crataegus mexicana leaves with vasodilator effect

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