Vasorelaxant Effects Induced by Red Wine and Pomace Extracts of Magliocco Dolce cv.

Abstract

Several epidemiological studies demonstrate that moderate (red) wine consumption may afford protection against cardiovascular diseases. Protection is ascribed to the biological activity of wine components, many of which, however, are discarded during winemaking. In vitro rat thoracic aorta rings contracted with phenylephrine or KCl were used to assess the vasorelaxant activity of extracts from wine pomaces (seeds and skins) of the Calabrian autochthonous grape variety Magliocco dolce (Arvino). NMR spectroscopy was used to ascertain their chemical composition. Data demonstrate that seed and skin, but not must, extracts are capable of relaxing vascular preparations in an endothelium-dependent manner, similarly to the red wine extract, due to the presence of comparable amounts of bioactive constituents. In rings pre-contracted with 20–30 mM KCl, only seed extracts showed a moderate relaxation. The most efficacious vasodilating extract (wine) showed a good antioxidant profile in both [(2,2-diphenyl-1-picrylhydrazyl)acid] radical (DPPH) and [2,2’-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid)] radical (ABTS) assays. In conclusion, winemaking from Magliocco dolce grape can provide potentially health-promoting by-products useful in cardiovascular disease management.

Characterization of Fruit Development, Antioxidant Capacity, and Potential Vasoprotective Action of Peumo (Cryptocarya alba), a Native Fruit of Chile

“…In this sense, hydroxytyrosol from olive oil improved acetylcholine-induced vasorelaxation under oxidative stress conditions [ 47 ]. The skin and seeds of grape ( Vitis vinifera ), with high levels of polyphenols (e.g., catechin and glycosylated flavonoids), contain vasorelaxant agents capable of relaxing in vitro vascular preparations in an endothelium-dependent manner [ 48 ]. Several reports have demonstrated the beneficial activity and preventive effects of catechins in the prevention of cardiovascular disease (CVD), by regulating lipid metabolism, vascular endothelial protection, and reducing blood pressure [ 49 , 50 ].…”

Improving Kefir Bioactive Properties by Functional Enrichment with Plant and Agro-Food Waste Extracts

“…For this reason, kefir enriched with plants extracts was proved to inhibit carbohydrate-hydrolyzing enzymes, being useful in the prevention of inflammation and chronic diseases. In addition, plant derived compounds were able to induce an intense vasorelaxation via different mechanisms [22,23]. In this context, Kwon et al [24] evaluated the α-amylase, α-glucosidase, and ACE inhibitory activity of kefir enriched with Rhodiola extract (2%).…”

Nanotechnologies: An Innovative Tool to Release Natural Extracts with Antimicrobial Properties

“…MCM-41 nanocarrier was fabricated by the co-condensation method using n-cetyl-n,n,n-trimethyl ammonium bromide as a template. In this view, different amounts of red propolis were embedded in silica mesoporous nanoparticles and tested against S. aureus at concentrations of 1050, 750, 500, 375, 225, and 150 µg/mL, finding an inhibition zone of approximately 19,20,21,17,16, and 17 mm in diameter, respectively. Poly(D,L-lactide-co-glycolide)/ poly(vinyl alcohol)…”

“…The search for new therapeutically active compounds has spurred researchers over the years to investigate natural compounds [ 12 , 13 , 14 , 15 , 16 , 17 ]. In particular, food and plant wastes represent interesting sources of biologically active molecules [ 18 , 19 , 20 , 21 , 22 , 23 , 24 ] and have been proposed as indigenous remedies [ 25 , 26 ]. Specifically, secondary metabolites from plants represent valuable bioactive ingredients [ 27 , 28 , 29 , 30 ] with remarkable antibacterial properties [ 31 , 32 ], useful in the treatment of several diseases.…”