Vasorelaxant effect of Alpinia zerumbet's essential oil on rat resistance artery involves blocking of calcium mobilization

Phytochemicals of Alpinia zerumbet: A Review

“…The essential oils of A. zerumbet mainly include monoterpenes, oxygenated monoterpenes, and oxygenated sesquiterpenes [ 123 ]. According to the previous 35 studies [ 2 , 4 , 8 , 14 , 18 , 31 , 34 , 36 , 37 , 38 , 41 , 47 , 49 , 51 , 52 , 53 , 54 , 70 , 74 , 87 , 92 , 96 , 97 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 ], the relative contents of the 33 major volatile components in the essential oils prepared from the leaves [ 2 , 4 , 8 , 14 , 31 , 34 , 36 , 37 , 38 , 41 , 47 , 49 , 51 , 52 , …”

“…The chemical constituents of the essential oils obtained from the leaves of A. zerumbet have been frequently reported [ 2 , 4 , 8 , 14 , 31 , 34 , 36 , 37 , 38 , 41 , 47 , 49 , 51 , 52 , 53 , 54 , 70 , 124 , 125 , 126 , 127 , 128 , 129 , 130 ]. In 1984, Luz et al [ 124 ] investigated the composition of the essential oils in A. zerumbet leaves collected 60 km from Manausare (Brazil) and identified p -cymene (9.4%), 1,8-cineol (14.9%), γ-terpinene (9.5%), and 4-terpineol (20.4%) [ 124 ].…”

“…In 1984, Luz et al [ 124 ] investigated the composition of the essential oils in A. zerumbet leaves collected 60 km from Manausare (Brazil) and identified p -cymene (9.4%), 1,8-cineol (14.9%), γ-terpinene (9.5%), and 4-terpineol (20.4%) [ 124 ]. Cavalcanti et al [ 41 ], Cunha et al [ 34 ], de Carvalho Castro et al [ 31 ], Gomes et al [ 51 ], and Rocha et al [ 54 ] clarified p -cymene, 1,8-cineol, and terpinen-4-ol as the main components of the essential oils from A. zerumbet leaves collected in Brazil. Other studies have revealed the chemical compositions of the essential oils derived from A. zerumbet leaves collected from Belém City, State of Pará (Brazil) in May 1997 [ 2 ], Rio de Janeiro (Brazil) [ 125 ], Núcleo de Pesquisas de Produtos Naturais (Brazil) [ 126 ], the municipality of Baturité (Brazil) in March 2010 [ 37 ], the Botanical Garden of the Universidade Federal Rural do Rio de Janeiro (GPS: 22°31′36.23 S, 44° 04′31.62 W) (Brazil) [ 127 ], Bacabal City, State of Maranhão (GPS: 4°13′2″ S, 44°46′60″ W) (Brazil) [ 52 ], and the Medicinal Plants Garden of the Federal University of Lavras (GPS: 21°12′4″ S, 44°57′58″ W) (Brazil) in September 2018 [ 128 ].…”

Essential Oils: Chemistry and Pharmacological Activities—Part II

“…Alpinia zerumbet has demonstrated antihypertensive and vasodilator effects. Rocha et al [ 206 ] pointed out that the essential oils of Alpinia zerumbet showed an endothelium-independent vasorelaxant effect in second-order branches of the mesenteric artery. There was a vasodilator effect mediated by the inhibition of Ca 2+ influx and release from intracellular storage, as well as an activation of the NOS/sGC pathway, being significant for the treatment of hypertension.…”

Vasorelaxant effects of biochemical constituents of various medicinal plants and their benefits in diabetes

“…Formations such as extracts, fractions, compounds, flavonoids, oils, formulations, and polysaccharides obtained from each medicinal plant are detailed in the table. Examples include the methanolic extract from Bauhinia forficata Link[ 39 ], n-butanol fraction from Mentha longifolia [ 40 ], compounds 1-4, 7, 8, and 16 from Plumeria rubra [ 41 ], total flavonoids from Euphorbia humifusa Willd[ 42 ], essential oil from Alpinia zerumbet [ 43 ], formulation from Bidens Pilosa [ 44 ], and polysaccharide from Coptis chinensis [ 38 ].…”