Vasorelaxant activity of phthalazinones and related compounds

Experimental study on the thermochemistry of 1-(2H)-phthalazinone and phthalhydrazide

“…Among the bicyclic nitrogen heterocycles, phthalazines are an interesting class of compounds with a large range of applications. They are suggested as having vaso relaxant [1], antihypertensive [2], or anti-HIV activities [3]. These compounds are referenced in chemiluminescence studies [4] and they are also used to prepare membranes for several purposes [5,6].…”

Ninhydrin in synthesis of heterocyclic compounds

“…Phthalazinones are an important class of heterocycles with diverse biological activities like vasorelaxant activity, 437 phosphodiesterase inhibitors, 438 inhibitor of Poly(ADP-ribose), 439 or protein kinase inhibitors. 440 The synthesis of biologically important phthalazinones was reported by Pramanik and co-workers.…”

Synthesis and Pharmacological Evaluation of 6‐Arylpyridazinones as Potent Vasorelaxants

“…The vasodilatory activity of the newly synthesized compounds was studied using descending thoracic aortic rings of Wistar rats precontracted with phenylephrine (10 -6 M), as previously reported (Olmo et al, 2006;Bansal et al, 2009). The pharmacological protocol was reviewed by the University of Salamanca, and animal usage was approved by the institutional ethical committee.…”