Vasoregulatory peptides pro-endothelin-1 and pro-adrenomedullin are associated with metabolic syndrome in the population-based KORA F4 study

Seißler, Jochen; Feghelm, N.; Then, Cornelia; Meisinger, Christa; Herder, Christian; Köenig, Wolfgang; Peters, Annette; Roden, Michael; Lechner, Andreas; Kowall, Bernd; Rathmann, Wolfgang

doi:10.1530/eje-12-0472

Cited by 37 publications

(32 citation statements)

References 37 publications

(51 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The applied analyses methods to determine glutamate pyruvate transaminase, glutamic oxaloacetic transaminase, gamma-glutamyl transpeptidase, C-reactive protein (Ruckert et al 2011), cystatin C (Goek et al 2012), and creatinine (Seissler et al 2012), concentrations have been described earlier. White blood cell count was determined from fresh venous EDTA blood using impedance measurements (Coulter ® LH 780, Beckman Coulter Inc., USA).…”

Section: Methodsmentioning

confidence: 99%

Associations between thyroid hormones and serum metabolite profiles in an euthyroid population

et al. 2013

Self Cite

View full text Add to dashboard Cite

The aim was to characterise associations between circulating thyroid hormones—free thyroxine (FT4) and thyrotropin (TSH)—and the metabolite profiles in serum samples from participants of the German population-based KORA F4 study. Analyses were based on the metabolite profile of 1463 euthyroid subjects. In serum samples, obtained after overnight fasting (≥8), 151 different metabolites were quantified in a targeted approach including amino acids, acylcarnitines (ACs), and phosphatidylcholines (PCs). Associations between metabolites and thyroid hormone concentrations were analysed using adjusted linear regression models. To draw conclusions on thyroid hormone related pathways, intra-class metabolite ratios were additionally explored. We discovered 154 significant associations (Bonferroni p < 1.75 × 10−04) between FT4 and various metabolites and metabolite ratios belonging to AC and PC groups. Significant associations with TSH were lacking. High FT4 levels were associated with increased concentrations of many ACs and various sums of ACs of different chain length, and the ratio of C2 by C0. The inverse associations observed between FT4 and many serum PCs reflected the general decrease in PC concentrations. Similar results were found in subgroup analyses, e.g., in weight-stable subjects or in obese subjects. Further, results were independent of different parameters for liver or kidney function, or inflammation, which supports the notion of an independent FT4 effect. In fasting euthyroid adults, higher serum FT4 levels are associated with increased serum AC concentrations and an increased ratio of C2 by C0 which is indicative of an overall enhanced fatty acyl mitochondrial transport and β-oxidation of fatty acids.Electronic supplementary materialThe online version of this article (doi:10.1007/s11306-013-0563-4) contains supplementary material, which is available to authorized users.

show abstract

Section: Methodsmentioning

confidence: 99%

Associations between thyroid hormones and serum metabolite profiles in an euthyroid population

et al. 2013

Self Cite

View full text Add to dashboard Cite

show abstract

“…Also, studies found association of ProADM with metabolic syndrome and its components, i.e. type 2 diabetes [39, 40]. …”

Section: Introductionmentioning

confidence: 99%

Pro-Adrenomedullin predicts 10-year all-cause mortality in community-dwelling patients: a prospective cohort study

Odermatt

Meili

Hersberger

et al. 2017

BMC Cardiovasc Disord

View full text Add to dashboard Cite

BackgroundSeveral studies found mid-regional pro-adrenomedullin (ProADM), the prohormone of the cardiovascular protein adrenomedullin, to be strongly associated with short-term mortality, mostly in the inpatient setting. We evaluated associations of ProADM levels with 10-year mortality in community-dwelling primary care patients with respiratory tract infections.MethodsThis is a post-hoc analysis using clinical and biomarker data of 134 primary care patients with respiratory tract infections. ProADM was measured on admission and after 7 days in batch-analysis. 10-year follow-up data was collected by GP, patient and relative tracing through phone interviews. We calculated Cox regression models and area under the receiver operating characteristics curves to assess associations of ProADM with 10-year all-cause mortality.ResultsDuring the 10-year follow-up 6% of included patients died. Median baseline ProADM blood levels (nmol/l) were significantly higher in non-survivors compared to survivors (0.5, IQR 0.4–1.3; vs. 0.2, IQR 0.1–0.5; p = 0.02) and showed a significant association with 10-year all-cause mortality in an age-adjusted cox regression model (HR: 2.5, 95%-CI: 1.0–6.1, p = 0.04). ProADM levels on day 7 showed similar results.ConclusionsThis posthoc analysis found an association of elevated ProADM blood levels and 10-year all-cause mortality in a primary care cohort with respiratory tract infections. Due to the methodological limitations including incomplete data regarding follow-up information and biomarker measurement, this study warrants validation in future larger studies.Trial registrationCurrent Controlled Trials, SRCTN73182671

show abstract

“…Significant positive correlation between ADRB2 and ADM expressions and between ROCK1 and HSPB1 during a post-exercise recovery process seems to confirm the protective effect of the adrenergic system on the cardiovascular function (Yahiaoui et al, 2008). The ADM gene encodes a vasoregulatory protein which controls vascular tone and enhances myocardial contractility (Seissler, 2012). The tendency of a lower ADM expression during exercise and higher during 15 minutes of recovery, respectively might reflect low vascular resistance during endurance training.…”

Section: Discussionmentioning

confidence: 99%

Adrenergic Response to Maximum Exercise of Trained Road Cyclists

Janikowska

Dziurowicz

Żebrowska

et al. 2014

Journal of Human Kinetics

View full text Add to dashboard Cite

The aim of this study was to evaluate adrenergic responses in the peripheral blood of trained road cyclists at rest, at maximal intensity of incremental bicycle exercise test, and during 15 minutes of recovery, as well as the relationship between them. Competitive male road cyclists, in the pre-competitive phase of a season, mean age 21.7 ± 6.4 years, and BMI 20.7 ± 0.8 kg·m−2, performed an incremental test on a bicycle ergometer with unloaded cycling for 5 min, then increased the load to 40 W every 3 min, up to maximal exercise intensity. The plasma catecholamine concentrations (epinephrine, norepinephrine) and oxygen uptake were estimated. The expression of 132 genes related to the adrenergic system in leukocytes was measured. A statistically significant increase in plasma epinephrine concentration (p < 0.01) was observed in response to exercise. The mean of maximal oxygen uptake was 65.7 ± 5.5 ml·kg−1·min−1. The RGS2 gene expression was highest regardless of the test phase for all athletes. The effort had a statistically significant influence on ADRB2 and RAB2A expression. In addition, the RAB2A, ADM and HSPB1 expression level increased during recovery. We can conclude that plasma epinephrine concentration and genes related to the adrenergic system such as ADM, ADRB2, CCL3, GPRASP1, HSPB1, RAB2A, RGS2 and ROCK1 seem to have an influence on the response to high-intensity exercise in trained cyclists.

show abstract

Vasoregulatory peptides pro-endothelin-1 and pro-adrenomedullin are associated with metabolic syndrome in the population-based KORA F4 study

Cited by 37 publications

References 37 publications

Associations between thyroid hormones and serum metabolite profiles in an euthyroid population

Associations between thyroid hormones and serum metabolite profiles in an euthyroid population

Pro-Adrenomedullin predicts 10-year all-cause mortality in community-dwelling patients: a prospective cohort study

Adrenergic Response to Maximum Exercise of Trained Road Cyclists

Contact Info

Product

Resources

About