Vasoproliferative retinopathy secondary to Waldenström's disease

Espinosa-Barberi, Glenda; González, Fayna; Fernández, S. Miranda; Pelaez, Daniel; Rivero, F. Medina; Saavedra, D. Marrero

doi:10.1016/j.oftale.2018.11.004

Cited by 1 publication

(5 citation statements)

References 10 publications

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“…Respect to OCTA, Leskov et al did not reveal any abnormalities of the retinal or choroidal vasculature, whereas Espinosa et al demonstrated damage on deep retinal capillary plexus and choriocapillaris. 5,6 In our patients, we were able to demonstrate abnormalities of both the superficial and deep retinal capillary plexus and in the choriocapillaris, although motion artifacts and hemorrhages should be considered when interpreting OCTA images. Because of that, we agreed with Espinosa et al in which intravascular hyperviscosity may affect both retinal and choroidal vessels.…”

Section: Discussionmentioning

confidence: 59%

“…Because of that, we agreed with Espinosa et al in which intravascular hyperviscosity may affect both retinal and choroidal vessels. 6…”

Section: Discussionmentioning

confidence: 99%

“…Because of that, we agreed with Espinosa et al in which intravascular hyperviscosity may affect both retinal and choroidal vessels. 6 Hyperviscosity retinopathy shows a good response to plasmapheresis and systemic therapy, whereas macular edema does not respond as well to this treatment. 2,3,10 An exception is one patient treated with ibrutinib reported by Leskov et al, who experienced a great improvement in visual acuity.…”

Section: Discussionmentioning

confidence: 99%

“…Leskov et al did not reveal any abnormalities of the retinal or choroidal vasculature, whereas Espinosa et al demonstrated damage on deep retinal capillary plexus and choriocapillaris. 5,6 The aim of our case report is to analyze multimodal imaging findings and treatment response in two cases of RVO due to WM, in order to improve our knowledge of the pathogenic mechanism of retinal hyperviscosity and ME in WM.…”

Section: Multimodal Imaging Of Two Cases Of Retinal Vein Occlusion Se...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Multimodal imaging of two cases of retinal vein occlusion secondary to Waldenstrom macroglobulinemia

Sargues

Hernández

Palop

et al. 2021

European Journal of Ophthalmology

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Purpose: To report multimodal imaging characteristics of two cases of retinal vein occlusion (RVO) secondary to Waldenstrom macroglobulinemia (WM). Case report: Case 1: An 82-year-old woman presented with vision loss. She had a history of WM. Best-corrected visual acuity (BCVA) was 20/100 Snellen equivalent in the right eye (OD) and 20/63 in the left eye (OS). Fundoscopy showed bilateral hemorrhages in posterior pole and along superotemporal arcade. Fluorescein angiography illustrated no macular leakage. Optical coherence tomography (OCT) revealed macular edema (ME). Optical coherence tomography angiography (OCTA) demonstrated abnormalities in choriocapillaris. A diagnosis of bilateral branch RVO was made and ME was treated with intravitreal dexamethasone, achieving stability. Case 2: A 65-year-old man presented with venous dilation, tortuosity, and intraretinal hemorrhages. BCVA was 20/20 in both eyes (OU). OCT showed ME and hyperreflective dots in choroid. A diagnosis of bilateral central RVO was made. Laboratory evaluation and bone narrow biopsy confirmed a diagnosis of WM. After that, our patient consulted because of vision loss. BCVA was 20/400 in OU. Fundoscopy and OCT demonstrated a worsening of the intraretinal hemorrhages and the ME. OCTA showed damage of choriocapillaris. Thus, intravitreal dexamethasone and plasmapheresis was advised. Two months after, BCVA was 20/40 in the OD and 20/32 in the OS. Also, fundoscopy and OCT improved. Conclusion: Early treatment of WM is truly important, with the aim of achieving a decrease in IgM levels in order to avoid toxic effect over the RPE that results in refractory ME.

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Section: Discussionmentioning

confidence: 59%

“…Because of that, we agreed with Espinosa et al in which intravascular hyperviscosity may affect both retinal and choroidal vessels. 6…”

Section: Discussionmentioning

confidence: 99%