Vasopressin/oxytocin-related peptides influence long-term memory of a passive avoidance task in the cuttlefish, Sepia officinalis

Bardou, Isabelle; Leprince, Jérôme; Chichery, Raymond; Vaudry, Hubert; Agin, Véronique

doi:10.1016/j.nlm.2009.10.004

Cited by 27 publications

(24 citation statements)

References 101 publications

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“…These results are somewhat similar to those of in situ hybridization experiments of mRNA expression of octopressin‐ and cephalotocin‐precursors in the octopus 15 . Interestingly, intravenously injected of a low dose of octopressin enhanced long‐term memory formation of a passive avoidance task, whereas a high dose attenuated it in Sepia officinalis 17 . Conversely, an enhancement of retention performance was observed at all doses of cephalotocin tested 17 …”

Section: Resultssupporting

confidence: 84%

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Oxytocin/vasopressin and gonadotropin‐releasing hormone from cephalopods to vertebrates

Minakata

2010

Annals of the New York Academy of Sciences

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Recent advances in peptide search methods have revealed two peptide systems that have been conserved through metazoan evolution. Members of the oxytocin/vasopressin-superfamily have been identified from protostomian and deuterostomian animals, indicating that the oxytocin/vasopressin hormonal system represents one of the most ancient systems. In most protostomian animals, a single member of the superfamily shares oxytocin-like and vasopressin-like actions. Co-occurrence of two members has been discovered in modern cephalopods, octopus, and cuttlefish. We propose that cephalopods have developed two peptides in the molluscan evolutionary lineage like vertebrates have established two lineages in the oxytocin/vasopressin superfamily. The existence of gonadotropin-releasing hormone (GnRH) in protostomian animals was initially suggested by immunohistochemical analysis using chordate GnRH antibodies. A peptide with structural features similar to those of chordate GnRHs was originally isolated from octopus, and an identical peptide has been characterized from squid and cuttlefish. Novel forms of GnRH-like molecules from other molluscs, an annelid, arthropods, and nematodes demonstrate somewhat conserved structures at the N-terminal regions; but structures of the C-terminal regions critical to gonadotropin-releasing activity are diverse. These findings may be important for the study of the molecular evolution of GnRH in protostomian animals.

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Section: Resultssupporting

confidence: 84%

“…Not surprisingly, a single member of the superfamily of proteins has both oxytocin‐like and vasopressin‐like actions 12,13 . In the evolution of molluscs, cephalopods have, like jawed vertebrates, secured two molecular forms with discriminative actions 14–17 …”

Section: Introductionmentioning

confidence: 99%

Oxytocin/vasopressin and gonadotropin‐releasing hormone from cephalopods to vertebrates

Minakata

2010

Annals of the New York Academy of Sciences

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“…Similarly, a very low SC OT dose (.1 ng/kg) given to mice performing the object recognition task improves the consolidation of episodic memory, and this effect is antagonized by a selective oxytocin receptor (OTR) antagonist (5). In the wake of findings regarding the enhancing effects of OT-like peptides on memory consolidation, a recent study of Sepia officinalis, a cephalopod mollusc known for its remarkable learning abilities, showed that a peripheral injection of cephalotocin (an OT analogue) 1 hour after training facilitated long-term memory in a passive avoidance task (7). Accordingly, intracerebral administration of OT (5 pg-50 ng/animal) to chicks enhances retention in a dose-and timedependent manner, with 5 ng being the best dose when given 1 minute after acquisition (8).…”

Section: Oxytocin In Learning and Memorymentioning

confidence: 99%

Learning About Oxytocin: Pharmacologic and Behavioral Issues

Chini

Leonzino

Braida

et al. 2014

Biological Psychiatry

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Despite the accumulating evidence suggesting that the neuropeptide oxytocin (OT) plays a role in neuropsychiatric disorders characterized by social dysfunction, the influence of OT on the nonsocial aspects of learning and memory have been less investigated. To foster research in this area, we review the effects of OT on learning and memory in animal models and humans. In healthy animal models, OT improves memory consolidation and extinction, but only if given at a low dose immediately after the acquisition phase. On the contrary, OT effects in healthy humans have been inconsistent; although, in this case, OT was always given before the acquisition phase and no dose-response curves have ever been drawn up. Interestingly, a specific impairment in the reversal of learning has been found in mice devoid of OT receptors and OT has been demonstrated to enhance fear extinction in rodents. All together, these data suggest that OT plays a role in elementary forms of behavioral flexibility and adaptive responses and support its therapeutic potential in neuropsychiatric disorders characterized by cognitive inflexibility and/or impairment (autism, schizophrenia, Alzheimer's disease, Parkinson disease, stroke, posttraumatic stress disorder). Accordingly, OT has been shown to improve cognitive flexibility in OT receptordeficient mice, and scattered findings indicate that intranasal OT has positive effects on the memory of patients with schizophrenia or posttraumatic stress disorders. Further studies of the therapeutic potential of OT as an enhancer of learning and memory are warranted.

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“…An animal with a lesion in the posterior part of the VL inhibits its tentacle strikes more slowly than a sham animal and shows no 24-hr retention of the task. 46 These peptides are widely expressed in cuttlefish brain, particularly in the vertical, optic, and inferior frontal lobes. These results slightly differ from those of ablation experiments.…”

Section: Brain Correlates Of Pt Learningmentioning

confidence: 99%