Vasopressin improves systemic hemodynamics without compromising mesenteric perfusion in the resuscitation of asphyxiated newborn piglets: a dose–response study

Abstract

Vasopressin treatment causes a dose-dependent baro-specific effect, while preserving cardiac function and cerebral and mesenteric hemodynamics in newborn piglets following H-R.

Vasopressin versus Dopamine for Treatment of Hypotension in Extremely Low Birth Weight Infants: A Randomized, Blinded Pilot Study

“…Vasopressin has minimal to no inotropic or chronotropic effects, 20 maintains cardiac function, 21 may cause pulmonary vasodilation, 22-24 and its vasoconstrictive effects are preserved during hypoxia and severe acidosis. 25 Thus, vasopressin is a potentially desirable vasopressor to compare with dopamine as initial therapy for the treatment of hypotension in ELBW infants.…”

Cerebral Blood Flow, Metabolism, and Head Trauma

“…Vasopressin is released from the posterior pituitary gland in response to; reduced plasma volume, increases in plasma osmolarity, cholecystokinin (Cheung et al 2012 ) . Reduced plasma volume activates secretion of vasopressin through pressure receptors (baroreceptors) in carotids, atria, and veins (Cheung et al 2012 ) .…”

“…Vasopressin is released from the posterior pituitary gland in response to; reduced plasma volume, increases in plasma osmolarity, cholecystokinin (Cheung et al 2012 ) . Reduced plasma volume activates secretion of vasopressin through pressure receptors (baroreceptors) in carotids, atria, and veins (Cheung et al 2012 ) . Changes in osmolality are Table 3; * P < 0.001 versus arti fi cial cerebrospinal fl uid, same barore fl ex status; P < 0.001 versus endothelin-1, same barore fl ex status; P < 0.005 versus sham denervated, same treatment.…”

“…Vasopressin secretion can be altered by several different substances both endogenously and exogenously. These include but are not limited to alcohol, angiotensin II, atrial natriuretic peptide (Cheung et al 2012 ) , andendothelin-1 (Rossi et al 2011 ) .…”

Year in review in Intensive Care Medicine 2012: I. Neurology and neurointensive care, epidemiology and nephrology, biomarkers and inflammation, nutrition, experimentals

“…Dose–response effects of vasopressin on systemic haemodynamics were evaluated, along with mesenteric and cerebral perfusion in asphyxiated newborn piglets. Vasopressin improved systemic haemodynamics without compromising cardiac function, cerebral and mesenteric haemodynamics in asphyxiated newborn piglets [86]. …”