Vasopressin, hypothalamo–neurohypophyseal system and aging

Frolkis, V.V.; Kvitnitskaya-Ryzhova, Tatyana; Dubiley, T. A.

doi:10.1016/s0167-4943(99)00032-1

Cited by 15 publications

(9 citation statements)

References 49 publications

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“…Vasopressin-secreting neurons show increased activity with aging. Vasopressin levels are elevated in the CSF of old rats and in plasma of older humans [41]. May and colleagues examined the rate of CSF production in 7 young and 7 elderly healthy normal volunteers [37].…”

Section: Discussionmentioning

confidence: 99%

Cerebrospinal Fluid Pressure Decreases with Older Age

et al. 2012

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PurposeClinical studies implicate low cerebrospinal fluid pressure (CSFP) or a high translaminar pressure difference in the pathogenesis of primary open angle glaucoma (POAG) and normal tension glaucoma (NTG). This study was performed to examine the effect of age, sex, race and body mass index (BMI) on CSFP.MethodsElectronic medical records from all patients who had a lumbar puncture (LP) performed at the Mayo Clinic from 1996–2009 were reviewed. Information including age, sex, race, height and weight, ocular and medical diagnoses, intraocular pressure (IOP) and LP opening pressure was obtained. Patients using medications or with medical diagnoses known to affect CSFP, and those who underwent neurosurgical procedures or where more than one LP was performed were excluded from analysis.ResultsElectronic medical records of 33,922 patients with a history of having an LP during a 13-year period (1996–2009) were extracted. Of these, 12,118 patients met all entry criteria. Relative to mean CSFP at age group 20–49 (mean 11.5±2.8 mmHg), mean CSFP declined steadily after age 50, with percent reduction of 2.5% for the 50–54 age group (mean 11.2±2.7 mmHg, p<0.002) to 26.9% for the 90–95 group (mean 8.4±2.4 mmHg, p<0.001). Females had lower CSFP than males throughout all age groups. BMI was positively and independently associated with CSFP within all age groups.ConclusionThere is a sustained and significant reduction of CSFP with age that begins in the 6th decade. CSFP is consistently lower in females. BMI is positively and independently associated with CSFP in all age groups. The age where CSFP begins to decline coincides with the age where the prevalence of POAG increases. These data support the hypothesis that reduced CSFP may be a risk factor for POAG and may provide an explanation for the mechanism that underlies the age-related increase in the prevalence of POAG and NTG.

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Section: Discussionmentioning

confidence: 99%

Cerebrospinal Fluid Pressure Decreases with Older Age

et al. 2012

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“…The results are conflicting. While some studies report increased basal plasma AVP with aging, others do not, and some even report a decrease (reviewed in [19]). In our experiments excretion of AVP was equal in mice of all ages while they were in water balance, consuming equal amounts of gel food containing 56% water (Figure 3A).…”

Section: Discussionmentioning

confidence: 99%

Increased Insensible Water Loss Contributes to Aging Related Dehydration

Dmitrieva

Burg

2011

PLoS ONE

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Dehydration with aging is attributed to decreased urine concentrating ability and thirst. We further investigated by comparing urine concentration and water balance in 3, 18 and 27 month old mice, consuming equal amounts of water. During water restriction, 3 month old mice concentrate their urine sufficiently to maintain water balance (stable weight). 18 month old mice concentrate their urine as well, but still lose weight (negative water balance). 27 month old mice do not concentrate their urine as well and lose even more weight than the 18 month old mice, indicating a larger negative water balance. Negative water balance in older mice is accompanied by increased vasopressin excretion, providing further evidence of dehydration. All 3 groups maintain water balance while consuming only the water in gel food containing 56% water. However, both older groups excrete a smaller volume of urine of higher osmolality, indicating greater extra urinary water loss. Since their feces also contain less water, the excess water lost by the older mice apparently is through other routes, presumably insensible loss through the respiratory tract and skin. The greater insensible water loss occurs at an earlier age (18 months) than decreased urine concentrating ability (27 months). We propose that insensible water loss through skin and respiration increases with age, making a major contribution to aging related dehydration.

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“…It has been suggested that the role of the CSF in VP regulation of brain function assumes more importance with increasing age. This is based on observations that the neurones responsible for secretion of vasopressin show signs of increased activity (larger nuclei), the number of vasopressin-containing fibres penetrating the third ventricle increase, and the concentration of the hormone is higher in old rats CSF and older human plasma (Frolkis et al, 1999). However, age-related elevation of CSF VP is likely to reduce CSF secretion rates significantly, and may interfere with the normal pathways.…”

Section: Hormone Interactionsmentioning

confidence: 99%

Ageing choroid plexus‐cerebrospinal fluid system

Preston¹

2001

Microsc. Res. Tech.

103

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The impact of ageing on the choroid plexus (CP)-CSF circulatory system has largely been un-investigated, or has been of interest only in relation to neurological disease. This paper reviews the evidence for age-related changes to the CP-CSF system and compares changes with disease states where appropriate. The changes discussed include reduced ion transport capabilities, evidence for oxidative stress, altered hormone interactions, decreased CSF secretion rates in animal models and the contradictory nature of human data, reduced clearance of protein from CSF, and slower fluid turnover. The potential impacts of these changes are highlighted, including the possibility of reduced resistance to stress insults and slow clearance of toxic compounds from CSF with specific reference to amyloid peptide. Other impacts may include the reduced ability of CSF to act as a circulating medium for hormone and growth factors to reach their brain targets, and reduced homeostasis of CSF nutrients (amino acids, vitamins), which might influence brain interstitial fluid homeostasis.

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Vasopressin, hypothalamo–neurohypophyseal system and aging

Cited by 15 publications

References 49 publications

Cerebrospinal Fluid Pressure Decreases with Older Age

Cerebrospinal Fluid Pressure Decreases with Older Age

Increased Insensible Water Loss Contributes to Aging Related Dehydration

Ageing choroid plexus‐cerebrospinal fluid system

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