Vasopressin-dependent neural circuits underlying pair bond formation in the monogamous prairie vole

Lim, Miranda M.; Young, Larry J.

doi:10.1016/j.neuroscience.2003.12.008

Cited by 266 publications

(227 citation statements)

References 45 publications

Supporting

Mentioning

215

Contrasting

Unclassified

Order By: Relevance

“…The VP is part of the basal ganglia reward circuitry and has a high density of both AVP V1a and dopamine receptors (14). Recently, scholars have suggested that the interaction of the dopaminergic and vasopressinergic systems in the VP encodes the rewarding properties of social interactions, facilitating social recognition and pair bonding in several mammalian species (15,34). Our data suggest that the vasopressinergic/dopaminergic interactions in the reward system (14) are evolutionarily stable across species and might be linked to a broader range of social behaviors as established by animal research so far.…”

Section: Discussionmentioning

confidence: 99%

“…AVP regulates male mammalian social behaviors such as affiliation, aggression, monogamy, and paternal behaviors (14). Scholars have suggested that AVP mediates male pair bonding in mammals by stimulating dopamine release in the VP, inducing reward associations with the partner (15). Rodent studies have also linked AVP with social recognition, an important capacity required for distinguishing between conspecifics (16).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Vasopressin increases human risky cooperative behavior

Brunnlieb

Nave

Camerer

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

The history of humankind is an epic of cooperation, which is ubiquitous across societies and increasing in scale. Much human cooperation occurs where it is risky to cooperate for mutual benefit because successful cooperation depends on a sufficient level of cooperation by others. Here we show that arginine vasopressin (AVP), a neuropeptide that mediates complex mammalian social behaviors such as pair bonding, social recognition and aggression causally increases humans' willingness to engage in risky, mutually beneficial cooperation. In two double-blind experiments, male participants received either AVP or placebo intranasally and made decisions with financial consequences in the "Stag hunt" cooperation game. AVP increases humans' willingness to cooperate. That increase is not due to an increase in the general willingness to bear risks or to altruistically help others. Using functional brain imaging, we show that, when subjects make the risky Stag choice, AVP down-regulates the BOLD signal in the left dorsolateral prefrontal cortex (dlPFC), a risk-integration region, and increases the left dlPFC functional connectivity with the ventral pallidum, an AVP receptor-rich region previously associated with AVP-mediated social reward processing in mammals. These findings show a previously unidentified causal role for AVP in social approach behavior in humans, as established by animal research.vasopressin | intranasal administration | cooperation | fMRI | neuroeconomics

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Vasopressin increases human risky cooperative behavior

Brunnlieb

Nave

Camerer

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

“…This notion was further supported by data showing that icv administration of AVP facilitated, while administration of a V1aR antagonist inhibited, selective aggression in male prairie voles . Further, site specific manipulation of AVP in the LS or VP, by administration of AVP or a V1aR antagonist, influenced partner preference formation, indicating the role of these brain regions in an AVP circuit important for pair bonding (Liu et al, 2001a;Lim et al, 2004c). It should be noted that central manipulations of AVP do not have similar effects on the behavior of promiscuous voles .…”

Section: Neuropeptidergic Regulation Of Social Attachmentmentioning

confidence: 91%

“…Alternatively, if pharmacological activation of a neurochemical receptor during the 1-6 hour social cohabitation induces partner preferences, it can be inferred that activation of this receptor is sufficient to induce pair bonding. Using this paradigm, several neurochemicals have been implicated in prairie vole social bonding including oxytocin (OT), arginine vasopressin (AVP), dopamine (DA), corticotrophin releasing factor (CRF), gamma-aminobutyric acid (GABA) and glutamate (Williams et al, 1992a;Winslow et al, 1993;Williams et al, 1994;Carter et al, 1995;Wang et al, 1998;Wang et al, 1999;Gingrich et al, 2000;Liu et al, 2001a;Aragona et al, 2003;Liu et al, 2003;Lim et al, 2004c;Curtis et al, 2005b;Aragona et al, 2006). In this review, we will focus on the involvement and interactions of the neuropeptides AVP and OT and the neurotransmitter DA in the regulation of pair bonding behavior in monogamous prairie voles.…”

Section: The Prairie Vole and Social Attachmentmentioning

confidence: 99%

The neurobiology of social attachment: A comparative approach to behavioral, neuroanatomical, and neurochemical studies

Young

Liu

Wang

2008

Comparative Biochemistry and Physiology Part C: Toxicology &

128

View full text Add to dashboard Cite

The formation and maintenance of social bonds in adulthood is an essential component of human health. However studies investigating the underlying neurobiology of such behaviors have been scarce. Microtine rodents offer a unique comparative animal model to explore the neural processes responsible for pair bonding and its associated behaviors. Studies using monogamous prairie voles and other related species have recently offered insight into the neuroanatomical, neurobiological, and neurochemical underpinnings of social attachment. In this review, we will discuss the utility of the microtine rodents in comparative studies by exploring their natural history and social behavior in the laboratory. We will then summarize the data implicating vasopressin, oxytocin, and dopamine in the regulation of pair bonding. Finally, we will discuss the ways in which these neurochemical systems may interact to mediate this complex behavior.

show abstract

“…Much of this work has focused on the nonapeptides oxytocin (OT) and vasopressin (VP). For example, region-specific manipulations of OT, VP or their receptors (OTR and V1aR) in the lateral septum (LS, [25]), ventral pallidum (VPall, [26]), nucleus accumbens (NAcc, [27,28]) and prefrontal cortex (PFC, [29]) can enhance or eliminate the propensity to bond, which has led to their inclusion in a 'pairbonding neural circuit' [20]. Not surprisingly, most of these structures are deeply associated with the 'social behaviour network' [30,31], a set of nuclei that are frequently implicated in modulating social behaviours and in which nonapeptides assert a tremendous influence.…”

Section: Introductionmentioning

confidence: 99%

Perinatal and juvenile social environments interact to shape cognitive behaviour and neural phenotype in prairie voles

et al. 2015

View full text Add to dashboard Cite

Social environments experienced at different developmental stages profoundly shape adult behavioural and neural phenotypes, and may have important interactive effects. We asked if social experience before and after weaning influenced adult social cognition in male prairie voles. Animals were raised either with or without fathers and then either housed singly or in sibling pairs. Males that were socially deprived before (fatherless) and after (singly housed) weaning did not demonstrate social recognition or dissociate spatial from social information. We also examined oxytocin and vasopressin receptors (OTR and V1aR) in areas of the forebrain associated with social behaviour and memory. Pre-and post-wean experience differentially altered receptor expression in several structures. Of note, OTR in the lateral septum-an area in which oxytocin inhibits social recognition-was greatest in animals that did not clearly demonstrate social recognition. The combination of absentee fathers on V1aR in the retrosplenial cortex and single housing on OTR in the septohippocampal nucleus produced a unique phenotype previously found to be associated with poor reproductive success in nature. We demonstrate that interactive effects of early life experiences throughout development have tremendous influence over brain -behaviour phenotype and can buffer potentially negative outcomes due to social deprivation.

show abstract

Vasopressin-dependent neural circuits underlying pair bond formation in the monogamous prairie vole

Cited by 266 publications

References 45 publications

Vasopressin increases human risky cooperative behavior

Vasopressin increases human risky cooperative behavior

The neurobiology of social attachment: A comparative approach to behavioral, neuroanatomical, and neurochemical studies

Perinatal and juvenile social environments interact to shape cognitive behaviour and neural phenotype in prairie voles

Contact Info

Product

Resources

About