Vasopressin as a Hemostatic in Gynecologic Surgery

Comparison of Hemodynamic Status and Complications Between Two Different Doses of Intramyometrial Vasopressin During Laparoscopic Myomectomy: A Retrospective Study, the Lesser the Better

“…Vasopressin is an hemostatic agent recycled for over and above 50 years, and there are published data reports supporting the usage of vasopressin to decrease blood loss during myomectomy. Likewise, there are published reports of adverse cardiac events that include cardiac arrest following vasopressin management [13][14][15]. These cardiac results are potentiated in patients with coronary insufficiency.…”

Sudden bradycardia and impending cardiac arrest by intra-myometrial vasopressin in laparoscopic myomectomy: a case report and review of literature

“…The first of these studies have been reported by Dillon et al almost sixty years ago on 20 patients in whom vasopressin was used to decrease blood loss associated with gynecologic surgery. 8 They used 4 U as the total maximum dose diluted in 20 ml of saline (0.2 U/ml). They injected 5-10 ml (1 to 2 U) at the beginning of the surgery, repeated the injections as needed, but did not exceed a total cutoff of 4 U.…”

Intramyometrial vasopressin as a haemostatic agent: Is it really safe?

“…Vasopressin as a haemostatic agent has been in use for more than 50 years, and there are published reports supporting the use of vasopressin to reduce blood loss during myomectomy and hysterectomy. [ 1 2 ] At the same time, there are published reports of adverse cardiac events including cardiac arrest following vasopressin. [ 3 4 ]…”

“…Vasopressin when given intramyometrially during myomectomy results in good surgical haemostasis. [ 1 2 ] At the same time, there are published reports of adverse cardiac events following vasopressin injection. [ 3 4 ] Resuscitation measures following such adverse cardiac events require understanding of pharmacodynamics of vasopressin administration.…”