Vasopressin and thirst in patients with posterior pituitary ectopia and hypopituitarism

Lukezic, Monica; Righini, Velella; Natale, B. Di; Angelis, Riccardo De; Norbiato, Guido; Bevilacqua, Maurizio; Chiumello, G

doi:10.1046/j.1365-2265.2000.01030.x

Cited by 10 publications

(2 citation statements)

References 16 publications

(21 reference statements)

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“…Our data in patients with hypopituitarism associated with EPP are in contrast with the few published papers on PP function which show milder to overt forms of CDI (6,8,9). In particular, compared with those with larger EPP or those with orthotopic PP, subjects with MPHD and small EPP size (!5 mm in T1 MRI images) have been described with various forms of PP dysfunction (8).…”

Section: Discussioncontrasting

confidence: 53%

“…Controversies exist, however, regarding neurohypophyseal function in subjects with ectopic posterior pituitary (EPP), the most common condition associated with congenital anterior pituitary deficiencies (1)(2)(3)(4)(5). Several studies have shown abnormal PP function, ranging from reduced vasopressin release after osmotic challenge, hypodipsia, or polydipsia (6) to persistent nocturnal enuresis or symptomatic CDI, in both familial (7) and sporadic cases of hypopituitarism associated with either isolated GH deficiency (IGHD) or multiple pituitary hormone deficiencies (MPHD) (6,8,9). Other studies which focused on the assessment of anterior pituitary function in patients with EPP have never reported water and electrolyte disturbances or CDI in these patient populations (1,2,(10)(11)(12)(13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

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Posterior pituitary (PP) evaluation in patients with anterior pituitary defect associated with ectopic PP and septo-optic dysplasia

Secco

Allegri

Iorgi

et al. 2011

European Journal of Endocrinology

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Objective: Controversies exist about posterior pituitary (PP) function in subjects with ectopic PP (EPP) and with cerebral midline defects and/or their co-occurrence. We investigate water and electrolyte disturbances in patients at risk for PP dysfunction. Design: The study was conducted in a single Pediatric Endocrinology Research Unit. Methods: Forty-two subjects with childhood-onset GH deficiency were subdivided into five groups: normal magnetic resonance imaging (nZ8, group 1); EPP (nZ15, group 2); septo-optic dysplasia (SOD) with normal PP (nZ4, group 3); EPP and SOD without (nZ7, group 4), and with additional midline brain abnormalities (nZ8, group 5). At a mean age of 16.0G1.1 years, they underwent a 120 min i.v. infusion with hypertonic 5% saline and evaluation of plasma osmolality (Posm), arginine vasopressin (AVP), thirst score (in groups 1 and 2), and urinary osmolality were performed. Results: Mean Posm and AVP significantly increased from baseline scores (284.7G4.9 mosm/kg and 0.6G0.2 pmol/l) to 120 min after saline infusion (300.5G8.0 mosm/kg and 10.3G3.3 pmol/l, P!0.0001). Group 5 showed higher mean Posm and lower mean AVP at all time points (P!0.0001). Mean thirst score did not show a significantly different trend between the groups 1 and 2. Urine osmolality was above 750 mosm/kg in all but seven patients after osmotic challenge.

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Section: Discussioncontrasting

confidence: 53%

Section: Introductionmentioning

confidence: 99%

Posterior pituitary (PP) evaluation in patients with anterior pituitary defect associated with ectopic PP and septo-optic dysplasia

Secco

Allegri

Iorgi

et al. 2011

European Journal of Endocrinology

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Ectopia of the pituitary

Saeger

2018

Pathologe

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The adenohypophysis has a large intrasellar part and two small parts at the pituitary stalk and the pharynx. Near this extrasellar pituitary tissue, and also in sinus sphenoidalis and sinus cavernosus, ectopic pituitary adenomas can develop. They are indistinguishable in structure and function from usual intrasellar adenomas. The neurohypophysis can show dystopias within complex malformations. In so-called pituitary stalk interruption syndrome, a real ectopia of the neurohypophysis is found at the eminentia mediana of the hypothalamus. Ectopic tissue in the pituitary is extremely rare: foci of ganglionic cells were found in the neurohypophysis and adrenocortical tissue in the adenohypophysis. Focal squamous epithelia in the anterior pituitary are a common finding but they are rather metaplastic from parenchymal cells than ectopic tissue. Small foci of ectopic salivary gland tissue are not rare in the intermediate zone.

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Pituitary stalk interruption syndrome

Voutetakis

2021

Handbook of Clinical Neurology

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Vasopressin and thirst in patients with posterior pituitary ectopia and hypopituitarism

Cited by 10 publications

References 16 publications

Posterior pituitary (PP) evaluation in patients with anterior pituitary defect associated with ectopic PP and septo-optic dysplasia

Posterior pituitary (PP) evaluation in patients with anterior pituitary defect associated with ectopic PP and septo-optic dysplasia

Ectopia of the pituitary

Pituitary stalk interruption syndrome

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