Vasopressin and the transmission of paternal behavior across generations in mated, cross-fostered Peromyscus mice.

Bester‐Meredith, Janet K.; Marler, Catherine A.

doi:10.1037/0735-7044.117.3.455

Cited by 108 publications

(89 citation statements)

References 34 publications

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“…Abusive caregiving may also alter the development of the maternal brain of offspring, leading to increased abusive care among abused offspring (Roth et al, 2009). In biparental species, fathers may similarly alter the neuroendocrine circuits regulating paternal behavior in male offspring leading to a transmission of variation in paternal behavior across generations (Bester-Meredith and Marler, 2003). These developmental effects of parent-offspring interactions may account for the intergenerational transmission of a broad range of behavioral phenotypes.…”

Section: Experience-dependent Epigenetic Transmissionmentioning

confidence: 99%

Early-Life Experience, Epigenetics, and the Developing Brain

Kundaković

Champagne

2014

Neuropsychopharmacol

254

182

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Development is a dynamic process that involves interplay between genes and the environment. In mammals, the quality of the postnatal environment is shaped by parent-offspring interactions that promote growth and survival and can lead to divergent developmental trajectories with implications for later-life neurobiological and behavioral characteristics. Emerging evidence suggests that epigenetic factors (ie, DNA methylation, posttranslational histone modifications, and small noncoding RNAs) may have a critical role in these parental care effects. Although this evidence is drawn primarily from rodent studies, there is increasing support for these effects in humans. Through these molecular mechanisms, variation in risk of psychopathology may emerge, particularly as a consequence of early-life neglect and abuse. Here we will highlight evidence of dynamic epigenetic changes in the developing brain in response to variation in the quality of postnatal parent-offspring interactions. The recruitment of epigenetic pathways for the biological embedding of early-life experience may also have transgenerational consequences and we will describe and contrast two routes through which this transmission can occur: experience dependent vs germline inheritance. Finally, we will speculate regarding the future directions of epigenetic research and how it can help us gain a better understanding of the developmental origins of psychiatric dysfunction.

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Section: Experience-dependent Epigenetic Transmissionmentioning

confidence: 99%

Early-Life Experience, Epigenetics, and the Developing Brain

Kundaković

Champagne

2014

Neuropsychopharmacol

254

182

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“…Interestingly, a similar behavioral and physiological change can be obtained by cross-fostering between species with a similar difference in social system, showing that the result of genetic manipulation does not mean at all that nongenetic factors are unimportant. Crossfostering of pups from the California mouse (Peromyscus californicus) in which males are aggressive and take part in parental care, to the white-footed mouse (P. leucopus) that does not show these behaviors, not only reduced these behaviors in the cross-fostered pups but also AVP content in the brain (Bester-Meredith & Marler, 2003).…”

Section: Major Single Gene Effects Are Not Always Straight Forwardmentioning

confidence: 99%

Unfolding personalities: The importance of studying ontogeny

Groothuis

Trillmich

2011

Developmental Psychobiology

140

123

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We aim to stimulate an ontogenetic approach to personalities. We explain the importance of studying development for understanding proximate and ultimate aspects of personality and critically discuss, partly by perhaps provocative statements, our current lack of knowledge and potential approaches to the study of personality development. We first clarify some terminology and argue for a difference between behavioral profiles (BP; at the descriptive level) and personality (at the explanatory level). We then focus on the issue of temporal stability of personality, arguing that based on evolutionary theory, neurophysiological knowledge, and recent findings, personality is probably less stable than often thought. Next we consider the potential influence of genes, discussing gene by environment correlations and interactions and argue that developmental changes in the regulation of DNA expression are probably more relevant than individual differences in DNA sequence. We end by suggesting perspectives for future research. ß 2011 Wiley Periodicals, Inc. Dev Psychobiol 53: 641-655, 2011.

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“…In studies examining the transmission of aggressive behaviour in the California mouse, adult males cross-fostered to the less aggressive white-footed mouse showed increased attack latencies in tests of residentintruder aggression and decreased arginine vasopressin immunoreactivity (AVP-ir) in the bed nucleus of the stria terminalis (BNST) compared with California mice raised by fathers of their own species [15]; that is, cross-fostered males more closely resembled their foster parents' behaviour. Mechanistically, paternal retrievals appear to be the postnatal environmental signal by which AVP-ir in the BNST and adult aggression are impacted [16,17]. Thus, fathers may influence offspring development when paternal involvement is typical for the species.…”

Section: Introductionmentioning

confidence: 99%

Non-genomic transmission of paternal behaviour between fathers and sons in the monogamous and biparental California mouse

Gleason

Marler

2013

Proc. R. Soc. B.

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Maternal behaviour has profound, long-lasting implications for the health and well-being of developing offspring. In the monogamous California mouse (Peromyscus californicus), care by both parents is critical for offspring survival. We tested the hypothesis that similar to maternal care in rodents, paternal huddling and grooming (HG) behaviour can be transmitted to future generations via behavioural mechanisms. In California mice, testosterone maintains paternal HG behaviour. In the present study, we randomly assigned a group of male California mice to castration or sham-operated conditions and allowed them to raise their offspring normally. Adult sons of these males were paired with a female, and they were observed interacting with their own offspring. We found that like their fathers, the sons of castrated males huddled and groomed their young at lower levels than the sons of sham-operated fathers. The sons of castrates also retrieved pups more frequently. When both parents were present, the sons of castrates also showed a trend towards engaging in less exploratory behaviour. These data support the hypothesis that paternal behaviour, like maternal behaviour, can be transferred to future generations via epigenetic mechanisms and suggest that in a biparental species both parents contribute to offspring behavioural development.

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Vasopressin and the transmission of paternal behavior across generations in mated, cross-fostered Peromyscus mice.

Cited by 108 publications

References 34 publications

Early-Life Experience, Epigenetics, and the Developing Brain

Early-Life Experience, Epigenetics, and the Developing Brain

Unfolding personalities: The importance of studying ontogeny

Non-genomic transmission of paternal behaviour between fathers and sons in the monogamous and biparental California mouse

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