Vasopressin and cognitive processes: Two event-related potential studies

Naumann, Ewald; Bartussek, Dieter; Kaiser, Walter; Fehm-Wolfsdorf, Gabriele

doi:10.1016/0196-9781(91)90223-c

Cited by 15 publications

(5 citation statements)

References 32 publications

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“…The CD38 gene is located on the short arm of chromosome 4 (4p15), 72 consists of eight exons, 36,37 and there is a large intron (approximately 40 kb) between exons 1 and 2 while exons 2–8 span on approximately 36 kb. A recent genome‐wide linkage scan found the 4p15 region to have suggestive evidence for linkage to ASD 73 .…”

Section: Autism Spectrum Disordersmentioning

confidence: 99%

“…They further showed that CD38 knockout mice displayed compatible phenotypes to mice with compromised OT systems, such as social amnesia and disruption in depolarization, and in calcium ion elevation. 70,71 The CD38 gene is located on the short arm of chromosome 4 (4p15), 72 consists of eight exons, 36,37 and there is a large intron (approximately 40 kb) between exons 1 and 2 while exons 2-8 span on approximately 36 kb. A recent genome-wide linkage scan found the 4p15 region to have suggestive evidence for linkage to ASD.…”

Section: Cd38mentioning

confidence: 99%

“…13 Only a few investigations have used INA of AVP to map the position of this closely related neuropeptide onto the geography of human social behavior. A set of important studies [34][35][36] show the effects of AVP on event-related potentials (ERPs) in healthy men via INA and after intravenous (i.v.) route.…”

Section: Introductionmentioning

confidence: 99%

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Arginine Vasopressin and Oxytocin Modulate Human Social Behavior

Ebstein

Israel

Lerer

et al. 2009

Annals of the New York Academy of Sciences

174

114

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Increasing evidence suggests that two nonapeptides, arginine vasopressin and oxytocin, shape human social behavior in both nonclinical and clinical subjects. Evidence is discussed that in autism spectrum disorders genetic polymorphisms in the vasopressin-oxytocin pathway, notably the arginine vasopressin receptor 1a (AVPR1a), the oxytocin receptor (OXTR), neurophysin I and II, and CD38 (recently shown to be critical for social behavior by mediating oxytocin secretion) contribute to deficits in socialization skills in this group of patients. We also present first evidence that CD38 expression in lymphoblastoid cells derived from subjects diagnosed with autism is correlated with social skill phenotype inventoried by the Vineland Adaptive Behavioral Scales. Additionally, we discuss molecular genetic evidence that in nonclinical subjects both AVPR1a and OXTR genes contribute to prosocial or altruistic behavior inventoried by two experimental paradigms, the dictator game and social values orientation. The role of the AVPR1a is also analyzed in prepulse inhibition. Prepulse inhibition of the startle response to auditory stimuli is a largely autonomic response that resonates with social cognition in both animal models and humans. First results are presented showing that intranasal administration of arginine vasopressin increases salivary cortisol levels in the Trier Social Stress test. To summarize, accumulating studies employing a broad array of cutting-edge tools in psychology, neuroeconomics, molecular genetics, pharmacology, electrophysiology, and brain imaging are beginning to elaborate the intriguing role of oxytocin and arginine vasopressin in human social behavior. We expect that future studies will continue this advance and deepen our understanding of these complex events.

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Section: Autism Spectrum Disordersmentioning

confidence: 99%

Section: Cd38mentioning

confidence: 99%

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Arginine Vasopressin and Oxytocin Modulate Human Social Behavior

Ebstein

Israel

Lerer

et al. 2009

Annals of the New York Academy of Sciences

174

114

View full text Add to dashboard Cite

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“…Recordings of evoked brain potentials (event-related potentials or ERPs) following IN-AVP provided functional evidence for a facilitated access of neuropeptides to the brain after nasal delivery (Fehm et al 2000). IN-AVP increased the amplitude of several components of the late ERPs, in particular the amplitude of P3, which reflects a higher level of cognitive and attention processing (Born et al 1986; Fehm-Wolfsdorf et al 1988; Naumann et al 1991; Pietrowsky et al 1989). More importantly, intravenous administration of AVP enhanced plasma AVP but did not affect the brain activity (measured by ERP) (Pietrowsky et al 1989), showing that the effects after IN-AVP are not dependent on the AVP plasma concentration.…”

Section: Methodology Of Ot Research In-ot and The Human Brainmentioning

confidence: 89%

A Precision Medicine Approach to Oxytocin Trials

Andari

Hurlemann

Young

2017

Behavioral Pharmacology of Neuropeptides: Oxytocin

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In this chapter, we introduce a new area of social pharmacology that encompasses the study of the role of neuromodulators in modulating a wide range of social behaviors and brain function, with the interplay of genetic and epigenetic factors. There are increasing evidences for the role of the neuropeptide oxytocin in modulating a wide range of social behaviors, in reducing anxiety, and in impacting the social brain network. Oxytocin also promotes social functions in patients with neuropsychiatric disorders, such as autism and reduces anxiety and fear in anxiety disorders. In this chapter, we will emphasize the importance of integrating basic research and clinical human research in determining optimal strategies for drug discoveries for social dysfunctions and anxiety disorders. We will highlight the significance of adopting a precision medicine approach to optimize targeted treatments with oxytocin in neuropsychiatry. Oxytocin effects on social behavior and brain function can vary from one individual to another based on external factors, such as heterogeneity in autism phenotype, childhood experiences, personality, attachment style, and oxytocin receptor polymorphisms. Hence, targeted therapies for subgroups of patients can help alleviating some of the core symptoms and lead to a better future for these patients and their families.

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“…Considering these two findings leads to the thesis that slighter alterations than those reflected in PSG as arousals are responsible for the different reactions under DDAVP versus placebo to the stimulus of a full bladder. Even though not reflected in distribution of sleep stages or arousal reactions, children with PME could express a higher level of alertness while under DDAVP, as suggested by studies showing an improved short time memory through DDAVP (22,23), enabling them to respond to a full bladder by oppressing the micturition reflex. This assumption is supported by the results of recent neurophysiological studies on pre‐pulse inhibition (PPI) of the startle reflex in enuretic children under treatment with DDAVP.…”

Section: Discussionmentioning

confidence: 99%

Effects of desmopressin on the sleep of children suffering from enuresis

2010

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Aim: To evaluate the effect of 1-desamino-8-D-Arginine Vasopressin (DDAVP) on sleep architecture and arousal reactions in children with primary monosymptomatic nocturnal enuresis (PME). Methods: A prospective, placebo-controlled, randomized, double-blind, cross-over study was performed on children suffering from bed-wetting. Placebo and DDAVP were given for 7 days each after which an unattended home polysomnography (PSG) was recorded. After lifting the blinding, the PSGs were compared. Results: A total of 20 children with PME, aged 6-15 years, were enrolled in the study. The number of wet nights decreased significantly with DDAVP treatment. Delta power, distribution of sleep stages, number of arousals, arousal index and the effect of arousals on sleep stages did not differ significantly. Bed-wetting occurred within each sleep stage and did not follow any particular pattern. In most cases, it was preceded by an arousal reaction, but no awakening occurred.Conclusion: DDAVP has no effect on the sleep architecture of children with PME when analysed by classical PSG, which is determined by collecting the electric activity of cortical neurons. Taking recent research findings into account, this supports the thesis that the disturbances causing PME occur at brain stem level and do not reach consciousness.

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Vasopressin and cognitive processes: Two event-related potential studies

Cited by 15 publications

References 32 publications

Arginine Vasopressin and Oxytocin Modulate Human Social Behavior

Arginine Vasopressin and Oxytocin Modulate Human Social Behavior

A Precision Medicine Approach to Oxytocin Trials

Effects of desmopressin on the sleep of children suffering from enuresis

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