Vasopressin analogues and spatial working memory in the 24-arm radial maze

Burešová, O.; Škopková, Jana

doi:10.1016/0196-9781(82)90005-5

Cited by 38 publications

(5 citation statements)

References 11 publications

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“…The results of this study, however, stand in contrast to those of the majority of animal studies in which the mnemonic effects of nonaversive vasopressin treatment in nonaversively motivated tasks have been examined (Buresova & Skopkova, 1980, 1982; Couk & Beckwith, 1982; Ettenberg et al, 1983; Packard & Ettenberg, 1985; Teal & Evans, 1982). There are several methodological differences in the present study that may account for this discrepancy.…”

Section: Discussioncontrasting

confidence: 73%

“…Although this maze is widely used as an index of both working and reference memory, the only published reports of memory enhancement in this paradigm involve the reattainment of stable performance following transfer of the maze to a novel environment (Gallagher, King, & Young, 1983). 2 However, it has recently been demonstrat- 2 The one possible exception is a study that examined the effect of the vasopressin analogue desgly NH 2 dDAVP in a 24-arm radial maze (Buresova & Skopkova, 1982). Those investigators observed a beneficial effect of the peptide in an initial study but could not replicate this finding.…”

mentioning

confidence: 99%

“…2The one possible exception is a study that examined the effect of the vasopressin analogue desgly NH 2 dDAVP in a 24-arm radial maze (Buresova & Skopkova, 1982). Those investigators observed a beneficial effect of the peptide in an initial study but could not replicate this finding.…”

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Improvement of memory by a vasopressin fragment: Importance on individual differences in mnemonic function.

Strupp¹

1989

Behavioral Neuroscience

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Three studies examined the effect of AVP4-9 on memory in an appetitively motivated task (the radial maze) to ascertain the generality of the mnemonic effects seen with vasopressin analogues in avoidance paradigms. Both pre- and posttrial administration of this vasopressin fragment significantly alleviated the forgetting seen in the control condition. However, a significant relation was observed between the proficiency of the rats and the degree to which their performance was improved by the posttrial AVP4-9 treatment. The more proficient subjects did not benefit from this treatment despite the fact that their performance provided evidence of significant forgetting. This pattern of results suggests that physiological differences of animals varying in mnemonic ability may account for their disparate response to the peptide treatment. The present findings support vasopressin's putative mnemonic role but indicate that exogenous administration of vasopressinlike peptides may improve memory only in certain subgroups, and possibly only under particular testing conditions.

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Improvement of memory by a vasopressin fragment: Importance on individual differences in mnemonic function.

Strupp¹

1989

Behavioral Neuroscience

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“…The large number of sequential locations that the rat can visit to obtain a reward makes the task ideal for investigating the effects of drugs or lesions upon serial order memory-i.e., whether locations visited first or last are remembered better (Kesner and Novak, 1982). The task is sensitive to the effects of brain lesions (Becker et al, 1980) and to numerous drugs (for review see Levin, 1988) that either impair or enhance performance, including inebriants such as ethanol (Devenport et al, 1983), endogenous neuropeptides such as vasopressin (Buresova and Skopkova, 1982), amnestic drugs such as scopolamine (Stevens, 1981;Watts et al, 1981;Okaichi and Jarrard, 1982), and neurotoxins such as trimethyltin (Walsh et al, 1982).…”

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confidence: 99%

Assessment of Spatial Memory Using the Radial Arm Maze and Morris Water Maze

Wenk

2004

CP Neuroscience

109

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Behavioral tasks must be evaluated in terms of the cognitive functions they require in order to be performed. All of the tasks described in this chapter can be used with each of four experimental manipulations: stimulation of a single brain region by drugs or small electrical current, impairment of normal function by production of a lesion or administration of appropriate pharmacological agents, recording of brain activity during the performance of a specific behavioral task, or behavioral phenotyping of transgenic and knockout mice for genes expressed in specific brain regions. This unit describes protocols for the radial arm maze task and the water maze task, both of which require intact spatial memory abilities.

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“…The large number of sequential locations that the rat can visit to obtain a reward makes the task ideal for investigating the effects of drugs or lesions upon serial order memory—i.e., whether locations visited first or last are remembered better (Kesner and Novak, ). The task is sensitive to the effects of brain lesions (Becker et al, ) and to numerous drugs (for review see Levin, ) that either impair or enhance performance, including inebriants such as ethanol (Devenport et al, ), endogenous neuropeptides such as vasopressin (Buresova and Skopkova, ), amnestic drugs such as scopolamine (Stevens, ; Watts et al, ; Okaichi and Jarrard, ), and neurotoxins such as trimethyltin (Walsh et al, ).…”

Section: Commentarymentioning

confidence: 99%

Assessment of Spatial Memory

Wenk

1999

CP Toxicology

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Behavioral tasks must be evaluated in terms of the cognitive functions they require. The tasks described in this unit are useful for detecting stimulation by drugs or a small electrical current, impairment of normal function by production of lesions or administration of a pharmacologic or toxicologic agent, recording activity during performance of a specific task, or behavioral phenotyping of transgenic or knockout mice. The radial arm maze test is used for basic working memory or working memory versus reference memory; the water maze task is used for spatial memory, spatial probe trials, or working memory; and the T-maze test is used for spatial memory, working versus reference memory, or spontaneous alternation.

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Vasopressin analogues and spatial working memory in the 24-arm radial maze

Cited by 38 publications

References 11 publications

Improvement of memory by a vasopressin fragment: Importance on individual differences in mnemonic function.

Improvement of memory by a vasopressin fragment: Importance on individual differences in mnemonic function.

Assessment of Spatial Memory Using the Radial Arm Maze and Morris Water Maze

Assessment of Spatial Memory

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