Vasoplegia After Restrictive Mitral Annuloplasty for Functional Mitral Regurgitation in Patients With Heart Failure

Vessem, Marieke E. van; Petrus, Annelieke H J; Palmen, Meindert; Braun, Jerry; Schalij, Martin J.; Klautz, Robert J.M.; Beeres, Saskia L.M.A.

doi:10.1053/j.jvca.2019.06.011

Cited by 5 publications

(6 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results from this study support that left ventricular dysfunction and more precisely, left ventricular ejection fraction equal to or lower than 40% is associated with a diminished vascular responsiveness during fentanyl anesthesia in this patient population. In contrast to more recent reports that identify cardiac surgery and cardiopulmonary bypass as predisposing factors for an attenuated vascular responsiveness [13,14,149], Schwinn et al [145] reported that phenylephrine-induced changes in systemic vascular resistance were increased during cardiopulmonary bypass and aortic cross-clamp in both HF and control subjects. This vascular responsiveness is of interest in HF patients that undergo cardiac surgery, since this patient population exhibits an increased risk for post-operative vasoplegia [150].…”

Section: Cell and Tissuementioning

confidence: 85%

Cardiac and Vascular α1-Adrenoceptors in Congestive Heart Failure: A Systematic Review

Kaykı-Mutlu

Papazisi

Palmen

et al. 2020

Cells

Self Cite

View full text Add to dashboard Cite

As heart failure (HF) is a devastating health problem worldwide, a better understanding and the development of more effective therapeutic approaches are required. HF is characterized by sympathetic system activation which stimulates α- and β-adrenoceptors (ARs). The exposure of the cardiovascular system to the increased locally released and circulating levels of catecholamines leads to a well-described downregulation and desensitization of β-ARs. However, information on the role of α-AR is limited. We have performed a systematic literature review examining the role of both cardiac and vascular α1-ARs in HF using 5 databases for our search. All three α1-AR subtypes (α1A, α1B and α1D) are expressed in human and animal hearts and blood vessels in a tissue-dependent manner. We summarize the changes observed in HF regarding the density, signaling and responses of α1-ARs. Conflicting findings arise from different studies concerning the influence that HF has on α1-AR expression and function; in contrast to β-ARs there is no consistent evidence for down-regulation or desensitization of cardiac or vascular α1-ARs. Whether α1-ARs are a therapeutic target in HF remains a matter of debate.

show abstract

Section: Cell and Tissuementioning

confidence: 85%

Cardiac and Vascular α1-Adrenoceptors in Congestive Heart Failure: A Systematic Review

Kaykı-Mutlu

Papazisi

Palmen

et al. 2020

Cells

Self Cite

View full text Add to dashboard Cite

show abstract

“…The univariate analysis found that recipient hypertension was associated with an odds of 0.77 (95% CI, 0.58-1.02; P = 0.07) for vasoplegia. 24 Similarly, a study by van Vessem et al 25 identified that prior hypertension was associated with reduced risk for vasoplegia (aOR, 0.28; (95% CI, 0.08-0.91; P = 0.034) in heart failure patients who had underwent mitral valve repair.…”

Section: Discussionmentioning

confidence: 96%

The Interaction of Amiodarone and Continuous-flow Left Ventricular Assist Device Use in Risk of Severe Primary Graft Dysfunction Following Heart Transplantation

Chinnadurai

Patel

Saeed

et al. 2022

Transplantation Direct

View full text Add to dashboard Cite

show abstract

“…Vasoplegia and vasoplegic shock are common complications after cardiac surgery, affecting between 5-29% of patients, especially after the use of cardiopulmonary bypass (Fig. 2) [47][48][49].…”

Section: Angiotensin 2 As a Novel Vasopressor In Vasoplegic Patients ...mentioning

confidence: 99%

Acute kidney injury after cardiac surgery

von Groote,

Sadjadi,

Zarbock

2023

Current Opinion in Anaesthesiology

View full text Add to dashboard Cite

Purpose of review Patients undergoing cardiac surgery are at high risk to develop cardiac surgery-associated acute kidney injury (CS-AKI) postoperatively. CS-AKI is associated with an increased risk for persistent renal dysfunction, morbidity and mortality. This review summarizes the epidemiology and pathophysiology of CS-AKI, as well as current treatment and prevention strategies. Recent findings As AKI is a syndrome with complex pathophysiology, no causative treatment strategies exist. Recent advances in the field of AKI biomarkers offer new perspectives on the issue and the implementation of biomarker-guided preventive strategies may reduce rates of CS-AKI. Finally, nephroprotective treatments and angiotensin II as a novel vasopressor may offer new opportunities for high-risk patients undergoing cardiac surgery. Summary Based on the described novel approaches for early detection, prevention and management of CS-AKI, a precision-medicine approach should be implemented in order to prevent the development of AKI in patients undergoing cardiac surgery.

show abstract

Vasoplegia After Restrictive Mitral Annuloplasty for Functional Mitral Regurgitation in Patients With Heart Failure

Cited by 5 publications

References 40 publications

Cardiac and Vascular α1-Adrenoceptors in Congestive Heart Failure: A Systematic Review

Cardiac and Vascular α1-Adrenoceptors in Congestive Heart Failure: A Systematic Review

The Interaction of Amiodarone and Continuous-flow Left Ventricular Assist Device Use in Risk of Severe Primary Graft Dysfunction Following Heart Transplantation

Acute kidney injury after cardiac surgery

Contact Info

Product

Resources

About