Vasomotor Effect after Acute Intoxication with Bupivacaine and Levobupivacaine in Rats Via Intraperitoneal Route Analyzed via Digital Infrared Imaging

Carstens, Angelo Manoel Grande; Tâmbara, Elizabeth Milla; Matias, Jorge Eduardo Fouto; Brioschi, Marcos Leal; Colman, Daniel R.; Carstens, M.

doi:10.1016/s0034-7094(11)70023-x

Cited by 1 publication

(2 citation statements)

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“…The most important finding of our study was that the inhibition of α 1 -adrenoceptor-mediated vasoconstriction by BUP was reversed by long-term treatment with LE, which significantly increased the pD 2 and E max values of the vasoconstrictive responses to an α 1 -adrenoceptor agonist in the isolated rat aortic rings. As the inhibitory effect of BUP on Phe-induced vasoconstriction was not removed via a complete washout, and the reversal effect of LE was easily washed out ( Figure 4C); we speculated that the reversal effect of LE was not a result of the interaction between LE and BUP.…”

Section: Discussionmentioning

confidence: 51%

“…However, unlike other local anesthetics, the therapeutic index of BUP is narrow, with small differences between cardiotoxic and neurotoxic concentrations, and its cardiotoxicity may occur without a neurological prodrome [1,2] . In cases of unintentional administration by either intra-arterial or intravenous injection, BUP may cause refractory cardiotoxicity and cardiovascular collapse, which are largely resistant to current standard cardiopulmonary resuscitation.…”

Section: Introductionmentioning

confidence: 99%

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Differential effects of short- and long-term bupivacaine treatment on α1-adrenoceptor-mediated contraction of isolated rat aorta rings and the reversal effect of lipid emulsion

Guo

Zhang

et al. 2015

Acta Pharmacol Sin

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Aim: Arterial function is significantly influenced by bupivacaine at both clinically relevant concentrations and toxic concentrations, but the underlying mechanisms are not fully understood. In the present study we investigated the role of α 1 -adrenoceptors in bupivacaine effects on isolated rat aortas. Methods: Isolated aortic rings were prepared from rats and suspended in an organ bath. Phenylephrine (Phe)-induced vasoconstriction and acetylcholine (ACh)-induced vasodilation were recorded through an isometric force transducer connected to a data acquisition system. Results: Administration of bupivacaine (30-300 μmol/L) produced mild vasoconstriction, and this response declined with repeated administrations. Treatment of the aortic rings with bupivacaine (3-30 μmol/L) for 20 min enhanced Phe-induced vasoconstriction, while treatment for 40 min suppressed Phe-induced vasoconstriction. Both the short-and long-term bupivacaine treatment suppressed ACh-induced vasodilation. Incubation of the aortic rings with 0.2%-0.6% lipid emulsion (LE) for 100 min significantly increased the pD 2 and E max values of Phe-induced vasoconstriction, and incubation with 0.4% LE for 100 min reversed the inhibition of bupivacaine on vasoconstriction induced by Phe (30 μmol/L). In contrast, incubation with LE suppressed ACh-induced vasodilation, even at a lower concentration and with a 5-min incubation. Conclusion: Bupivacaine exerts dual effects on α 1 -adrenoceptor-mediated vasoconstriction of isolated rat aortic rings: short-term treatment enhances the response, while long-term treatment inhibits it; the inhibition may be reversed via long-term incubation with LE.

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Section: Discussionmentioning

confidence: 51%

Section: Introductionmentioning

confidence: 99%