Vasomodulation Influences on the Transdermal Delivery of Ibuprofen

Carter, Stephen G.; Zhu, Zhou; Váradi, Gyula; Veves, Aristidis; Riviere, Jim E.

doi:10.1002/jps.23719

Cited by 8 publications

(4 citation statements)

References 48 publications

(89 reference statements)

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“…While the substance benfotiamine has been available for use as a solid and orally delivered therapeutic for several years the development of a novel topical formulation of benfotiamine has been completed for these studies. We formulated benfotiamine into topical preparation to maximize local drug accumulation and to minimize systemic distribution [65]. The goal of these formulations and administration route was to deliver significantly greater quantities of the drug to the afflicted peripheral dermal neuronal tissue.…”

Section: Resultsmentioning

confidence: 99%

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Efficient Transdermal Delivery of Benfotiamine in an Animal Model

2015

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We designed a transdermal system to serve as a delivery platform for benfotiamine utilizing the attributes of passive penetration enhancing molecules to penetrate through the outer layers of skin combined with the advance of incorporating various peripherally-acting vasodilators to enhance drug uptake. Benfotiamine, incorporated into this transdermal formulation, was applied to skin in an animal model in order to determine the ability to deliver this thiamine pro-drug effectively to the sub-epithelial layers. In this proof of concept study in guinea pigs, we found that a single topical application of either a solubilized form of benfotiamine (15 mg) or a microcrystalline suspension form (25 mg) resulted in considerable increases of the dephosphorylated benfotiamine (S-benzoylthiamine) in the skin tissue as well as in significant increases in the thiamine and thiamine phosphate pools compared to control animals. The presence of a ~8000x increase in thiamine and increases in its phosphorylated derivatives in the epidermis

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Section: Resultsmentioning

confidence: 99%

“…The topical formulation termed as 3 % benfotiamine was prepared according to a VALE formulation [65] and contained 3 % benfotiamine in soluble form, neutralized with arginine. The 5 % topical formulation contained 5 % benfotiamine, also in a VALE formulation, but in microcrystalline form.…”

Section: Methodsmentioning

confidence: 99%

Efficient Transdermal Delivery of Benfotiamine in an Animal Model

2015

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“…Ibuprofen is a nonselective inhibitor of cyclooxygenase (COX) required for the synthesis of prostaglandins via the arachidonic acid pathway. COX is required to convert arachidonic acid to prostaglandin H2 (PGH2), so inhibition of COX enzymes results in a decrease in the body's production of prostaglandin enzymes [28].…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Characterization of Ibuprofen and Ceftriaxone loaded Electrospun Cellulose Acetate Nanofiber Layers as a Model of Targeted Drug Delivery System

Satriawan

Khotib

Nasir³

et al. 2023

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This study aims to study the process of fabricating and characterization nanofibers based on cellulose acetate polymer filled with ceftriaxone and ibuprofen using the electrospinning method as a model for a targeted drug delivery system. Cellulose acetate has been successfully fabricated into nanofibers using the electrospinning method and filled with ceftriaxone and ibuprofen. The resulting nanofibers have an average diameter in the range of 412.5 – 558.5 nm under the conditions of the electrospinning process, namely 22 kV voltage, 15 cm distance, and flow rate. 0.005 mL/min using acetone/DMAc (2:1). Based on the data generated from the FTIR test, homogeneity, and drug release test, it is known that the resulting nanofibers, namely cellulose acetate, cellulose acetate-ceftriaxone, and cellulose acetate-ibuprofen, have good morphological characteristics, homogeneity, and release rate so that they have the potential to be used as a targeted drug delivery system

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“…Na atualidade, reconhece-se que o sistema tegumentar intacto pode ser usado como uma porta de administração sistêmica ou local de drogas (Banga, 2011). A administração transdérmica de fármacos oferece muitas vantagens sobre outras vias de administração com potencial eficácia superior e efeitos colaterais mínimos, para uma variedade de condições médicas e de doenças (Carter et al, 2013). Sob diversas circunstâncias, as vantagens culminam na efetividade de tratamento com facilidade de aplicação, competente entrega do princípio ativo e consequente conforto ao seguimento de tratamento pelos pacientes (Carter et al, 2013).…”

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Avaliação da liberação da rutina associada ao ultrassom contínuo

Valandro

Tassinary

Bianchetti

et al. 2015

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A pele intacta pode ser usada como uma porta de administração sistêmica. Profissionais da saúde vêm associando princípios ativos ao recurso ultrassônico, técnica denominada fonoforese. Um princípio ativo comumente utilizado na prática clínica é a rutina. A rutina classifica-se como um flavonóide da classe dos flavonóis, é também utilizada como antioxidante, na prevenção ou tratamento da deficiência venosa ou linfática e da fragilidade ou permeabilidade capilar. O objetivo deste estudo foi investigar a liberação de gel contendo rutina 5% frente à aplicação de fonoforese (US contínuo) in vitro para que, possa ser avaliada a eficácia do seu emprego terapêutico. Foram preparadas amostras contendo rutina 5% em meio hidrogel, as amostras foram analisadas com e sem a aplicação da fonoforese nos tempos de 5, 10, 15 e 20 minutos. Os resultados mostram que não existe diferença em termos de difusão em 5 e 10 minutos, porém nos tempos 15 e 20 minutos se pode evidenciar um incremento significativo do princípio ativo para o meio receptor quando aplicada a fonoforese. O US contínuo se apresentou como facilitador no processo de liberação da rutina para o meio, sendo que este fato está relacionado ao tempo de irradiação sonora.

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Vasomodulation Influences on the Transdermal Delivery of Ibuprofen

Cited by 8 publications

References 48 publications

Efficient Transdermal Delivery of Benfotiamine in an Animal Model

Efficient Transdermal Delivery of Benfotiamine in an Animal Model

Fabrication and Characterization of Ibuprofen and Ceftriaxone loaded Electrospun Cellulose Acetate Nanofiber Layers as a Model of Targeted Drug Delivery System

Avaliação da liberação da rutina associada ao ultrassom contínuo

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