Vasodilatory and Secretagogue Roles of the Prostaglandin D2 (PGD₂) Receptor in Nasal Mucosa and Airways of Different Species.

Role of α2-adrenoceptors in Electrical Field Stimulation–induced Contraction of Pig Nasal Mucosa and Pharmacologic Characterization of a Novel α2C-adrenoceptor Agonist

“…Finally, the prostaglandin D 2 receptors, potent inducer of nasal congestion, 38 had no effect on neurogenic vasomotor contractility (data not shown) but had vasodilatory and secretagogue roles in nasal mucosa and airways of different species. 39 In conclusion, postjunctional ␣ 2 -and ␣ 1 -adrenoceptors are activated by neurally released norepinephrine from sympathetic nerve endings, indicating that neurogenic vasomotor contractility in pig nasal mucosa is regulated mostly by an adrenergic mechanism. ␣ 2 -Adrenoceptors are also distributed prejunctionally and mediate a feedback inhibitory effect on norepinephrine release from postganglionic sympathetic terminals.…”

“…Finally, the prostaglandin D 2 receptors, potent inducer of nasal congestion, 38 had no effect on neurogenic vasomotor contractility (data not shown) but had vasodilatory and secretagogue roles in nasal mucosa and airways of different species. 39…”