Vasodilators in acute circulatory failure

Blakeley, Chris; Tinker, J.

doi:10.1007/bf01693698

Cited by 2 publications

(2 citation statements)

References 81 publications

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“…Vasodilators such as sodium nitroprusside or nitroglycerine reduce the vascular smooth muscle tone independently of sympathetic discharge (4,21). Alphablocking agents such as phentolamine, chlorpromazine or droperidol stop the efferentation at the receptor level (4,14); the agents used as anaesthetics such as enflurane, diazepam, thiopental, and fentanyl, at least in part, at the level of the central nervous system.…”

Section: Discussionmentioning

confidence: 99%

“…Alphablocking agents such as phentolamine, chlorpromazine or droperidol stop the efferentation at the receptor level (4,14); the agents used as anaesthetics such as enflurane, diazepam, thiopental, and fentanyl, at least in part, at the level of the central nervous system. Hence, it would be of interest to also know the effects of these agents on the sympathetic discharge in man, but this exploration is outside the scope of clinical situations.…”

Section: Discussionmentioning

confidence: 99%

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Spontaneous oscillation of the systemic arterial pressure during cardiopulmonary bypass in man. The effects of some drugs used during the operation

Vainionpää

Timisjärvi

1987

Basic Res Cardiol

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Despite the fact that the blood flow maintained during cardiopulmonary bypass is rather steady in the extracorporeal pump output, the arterial pressure under high-dose fentanyl anaesthesia quite often shows sinusoidal oscillations. In the present study the duration of an oscillatory cycle was on average 17.6 +/- 3.6 s, its amplitude 7.3 +/- 1.6 mm Hg and mean systemic arterial pressure 75 +/- 12 mm Hg. The oscillation is affected by the drugs used under bypass conditions. In our series of clinical observations the blood pressure oscillation disappeared under the influence of chlorpromazine, phentolamine, droperidol, and enflurane, and it disappeared or at least was distinctly attenuated under fentanyl, thiopental, diazepam, sodium nitroprusside, nitroglycerin, acebutolol, and potassium chloride. Pancuronium, atropine and furosemide appeared to be practically ineffective. In spite of the fact that the drugs used affected several sites of the sympathetic efferent chain, the disappearance and attenuation of the oscillation were associated with a simultaneous decrease of blood pressure. Hence, it is suggested that the occurrence of the oscillations requires some level of peripheral vascular tone.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Spontaneous oscillation of the systemic arterial pressure during cardiopulmonary bypass in man. The effects of some drugs used during the operation

Vainionpää

Timisjärvi

1987

Basic Res Cardiol

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Effects of Intravenous Nitroglycerin on Hemodynamics in Neonates with Refractory Congestive Heart Failure of PFC

Tamura¹,

Kawano²

1990

Pediatrics International

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(1) Continuous intravenous infusion (2–10 μ/kg/min) of nitroglycerin (TNG) was administered to 20 neonates consisting of 17 with refractory congestive heart failure and 3 with PFC (Persistent Fetal Circulation). (2) AT doses of 2–4 μ/kg/min, there were no significant changes in heart rate or systemic blood pressue. (3) At doses of 2–4 μ/kg/min, the CVP was significantly reduced and urnary output increased. (4) Echocardiograms revealed a significant decrease in LVS at 4 – 5 μ/kg/min. In addition, the EF and cardiac output were significantly increased at 2 – 5 μ/kg/min. (5) The right ventricle systolic time interval (STI) was reduced significantly at 2 μ/kg/min. The left ventricle STI was not reduced below doses of 4 μ/kg/min. (6) In the dose range 2 – 5 μ/kg/min, TNG is an effective and safe vasodilator in the treatment of refractory congestive heart failure or PFC in neonates.

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Vasodilators in acute circulatory failure

Cited by 2 publications

References 81 publications

Spontaneous oscillation of the systemic arterial pressure during cardiopulmonary bypass in man. The effects of some drugs used during the operation

Spontaneous oscillation of the systemic arterial pressure during cardiopulmonary bypass in man. The effects of some drugs used during the operation

Effects of Intravenous Nitroglycerin on Hemodynamics in Neonates with Refractory Congestive Heart Failure of PFC

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