Vasodilator Effects of Red Wines in Subcutaneous Small Resistance Artery of Patients With Essential Hypertension

Porteri, Enzo; Rizzoni, Damiano; Ciuceis, Carolina De; Boari, Gianluca E.M.; Platto, Caterina; Pilu, Annamaria; Miclini, Marco; Rosei, Claudia Agabiti; Bulgari, Giuseppe; Rosei, Enrico Agabiti

doi:10.1038/ajh.2009.280

Cited by 13 publications

(9 citation statements)

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“…Ellagitannin-rich medicinal plant extracts and food products are currently commercialized and consumed due to their potential positive effects on diseases possessing inflammatory background. In inflammation-associated cardiovascular diseases, such products as nuts, pomegranate, blackberries, strawberries, and oak-aged red wine, were proven to exhibit beneficial effect in many human interventional studies [1][2][3][4][5][6]. A recent study conducted on people with a high cardiovascular risk has clearly shown, that regular nut intake (walnuts, almonds, and hazelnuts) significantly reduced the incidence of major cardiovascular events connected with excessive inflammatory response [7].…”

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confidence: 99%

Influence of Gut Microbiota-Derived Ellagitanninsʼ Metabolites Urolithins on Pro-Inflammatory Activities of Human Neutrophils

2014

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Introduction !Ellagitannin-rich medicinal plant extracts and food products are currently commercialized and consumed due to their potential positive effects on diseases possessing inflammatory background. In inflammation-associated cardiovascular diseases, such products as nuts, pomegranate, blackberries, strawberries, and oak-aged red wine, were proven to exhibit beneficial effect in many human interventional studies [1][2][3][4][5][6]. A recent study conducted on people with a high cardiovascular risk has clearly shown, that regular nut intake (walnuts, almonds, and hazelnuts) significantly reduced the incidence of major cardiovascular events connected with excessive inflammatory response [7]. Although many in vitro studies conducted for extracts and single compounds deal with the explanation of the mechanism of action, the extrapolation of their results on in vivo processes raises many difficulties due to the not well-established bioavailability of ellagitannins [1]. Ellagitannins are hydrophilic, high-molecular-weight dietary polyphenols containing hexahydroxydiphenoyl subunits. They are subsequently transformed by intestinal microbiota to dibenzo [b,d]pyran-6-one derivatives, urolithins. It was established on human model that ellagitannins from strawberries, raspberries, oak-aged wine, pomegranate juice, and nuts could be transformed by intestinal microbiota to urolithins, which are the main biomarkers detected in human plasma following the intake of ellagitannin-rich food products and medicinal plants. These metabolites in contrary to ellagitannins are lipophilic compounds which have a good bioavailability and may be present in plasma in the range of 0.5 to 18.6 µM [8][9][10]. Because of their catechol-like structure after absorption they are a potential substrate for catechol-Omethyl transferase (COMT) enzyme, which increases lipophilicity and may lead to biological Abstract ! Ellagitannin-rich products exhibit beneficial influence in the case of inflammation-associated diseases. Urolithins, metabolites of ellagitannins produced by gut microbiota, in contrary to high molecular weight hydrophilic parental polyphenols, possess well established bioavailability. Because of the important role of neutrophils in progression of inflammation, the influence of urolithins on their pro-inflammatory functions was tested. Urolithin B at a concentration of 20 µM showed significant inhibition of interleukin 8 and extracellular matrix-degrading enzyme MMP-9 production. It was also significantly active in prevention of cytochalasin A/formyl-met-leuphenylalanine-triggered selectin CD62L shedding. Urolithin C was the only active compound towards inhibition of elastase release from cytochalasin A/formyl-met-leu-phenylalanine-stimulated neutrophils with 39.0 ± 15.9 % inhibition at a concentration of 5 µM. Myeloperoxidase release was inhibited by urolithins A and C (at 20 µM by 46.7 ± 16.1 and 63.8 ± 8.6 %, respectively). Urolithin A was the most potent reactive oxygen species release inhibitor both in formyl-met-leu-phenylalan...

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Influence of Gut Microbiota-Derived Ellagitanninsʼ Metabolites Urolithins on Pro-Inflammatory Activities of Human Neutrophils

2014

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“…Previous studies have demonstrated that ellargic acid improved vascular response affected by hypertension (Jordão et al, 2017). Several authors have also suggested that decrease in blood pressure and vasodilator effect could be created by phenolic acids such as tannic acid or ferulic acid (Turgut et al, 2015;Porteri et al, 2010). Taking into account these phenolic acids identified in the ethanolic extracts of O. americanum and P. lappacea, we could suggest that the effect of OAE and PLE against high blood pressure could be expained by their vasorelaxant property (Drăgan et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

UHPLC-DAD characterization of bioactive secondary metabolites from Ocimum americanum and Pupalia lappacea extracts: Antioxidant activity and antihypertensive effects on L-NAME-induced hypertensive rats

̈¹,

Amoussa²,

Adamou³

et al. 2019

J. Pharmacognosy Phytother.

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Ocimum americanum L. (Lamiaceae) and Pupalia lappacea (L) Juss. (Amaranthaceae) are two plants used in Bénin to manage hypertension. Little scientific data is available on the antihypertensive properties of these plants. Therefore, we investigated the antihypertensive potential of ethanolic extracts of O. americanum and P. lappacea on L-NAME-induced hypertensive rats. The DPPH free radical scavenging potential, Fe 3+ reducing capacity, superoxide anion radical and hydrogen peroxide scavenging were assessed. Extracts were also screened for their active compounds using ultimate high-performance liquid chromatography 3000. CODA™ non-invasive blood pressure system was used to record blood pression parameters. Both extracts induced significant decrease of systolic, diastolic blood pressure and mean arterial pression. O. americanum extract at 250 mg/kg body weight, decreased mean blood pressure (MBP) from 146 ± 4.80 to 98.4 ± 9.44 mmHg and P. lappacea extract from 154.4 ± 11.28 to 111.8 ± 9.44 mmHg. A significant decrease of MBP was also observed with Losartan and Captopril at 100 mg/kg body weight. P. lappacea showed the higest ferric reducing/antioxidant power 4905 ± 87.79 µmol AAE g-1. Superoxide anion and hydrogen peroxide scavenging activities showed higher activity, 68.42 ± 3.68 and 38.68 ± 4.18%, respectively for O. americanum. The chromatography analysis of extracts suggested the presence of ferulic acid, chlorogenic, tannic, ellargic, caffeic acids and chrysin, rutin and isorhamnetin. The obtained results justify the traditional use of O. americanum and P. lappacea in management of hypertension in southern Bénin.

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“…Alcohol, particularly in red wine, is known to have vasodilator effects in both normotensive and hypertensive individuals ( Porteri et al, 2010 ; Barden et al, 2013 ). While ingestion of mixed wine caused a decrease in peripheral resistance, there was little impact on MBP, which could be explained by increases in HR and CO.…”

Section: Discussionmentioning

confidence: 99%

Early and Late Cardiovascular and Metabolic Responses to Mixed Wine: Effect of Drink Temperature

2018

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Aim: Red wine is usually ingested as an unmixed drink. However, mixtures of wine with juices and/or sucrose (mixed wine) are becoming more and more popular and could be ingested at either cold or hot temperature. Although the temperature effects on the cardiovascular system have been described for water and tea, with greater energy expenditure (EE) and lower cardiac workload with a colder drink, little information is available on the impact of temperature of alcoholic beverages on alcoholemia and cardiometabolic parameters. The purpose of the present study was to compare the acute cardiovascular and metabolic changes in response to mixed wine ingested at a cold or at a hot temperature.Methods: In a randomized crossover design, 14 healthy young adults (seven men and seven women) were assigned to cold or hot mixed wine ingestion. Continuous cardiovascular, metabolic, and cutaneous monitoring was performed in a comfortable sitting position during a 30-min baseline and for 120 min after ingesting 400 ml of mixed wine, with the alcohol content adjusted to provide 0.4 g ethanol/kg of body weight and drunk at either cold (3°C) or hot (55°C) temperature. Breath alcohol concentration was measured intermittently throughout the study.Results: Overall, alcoholemia was not altered by drink temperature, with a tendency toward greater values in women compared to men. Early responses to mixed wine ingestion (0–20 min) indicated that cold drink transiently increased mean blood pressure (BP), cardiac vagal tone, and decreased skin blood flow (SkBf) whereas hot drink did not change BP, decreased vagal tone, and increased SkBf. Both cold and hot mixed wine led to increases in EE and reductions in respiratory quotient. Late responses (60–120 min) led to similar cardiovascular and metabolic changes at both drink temperatures.Conclusion: The magnitude and/or the directional change of most of the study variables differed during the first 20 min following ingestion and may be related to drink temperature. By contrast, late changes in cardiometabolic outcomes were similar between cold and hot wine ingestion, underlying the typical effect of alcohol and sugar intake on the cardiovascular system.

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Vasodilator Effects of Red Wines in Subcutaneous Small Resistance Artery of Patients With Essential Hypertension

Abstract: Our results suggest red wines are more potent vasodilator than ethanol alone, possibly depending on the content of polyphenols or tannic acid. HT show similar responses compared with NT, indicating that red wine is not harmful in this population.

Cited by 13 publications

References 35 publications

Influence of Gut Microbiota-Derived Ellagitanninsʼ Metabolites Urolithins on Pro-Inflammatory Activities of Human Neutrophils

Influence of Gut Microbiota-Derived Ellagitanninsʼ Metabolites Urolithins on Pro-Inflammatory Activities of Human Neutrophils

UHPLC-DAD characterization of bioactive secondary metabolites from Ocimum americanum and Pupalia lappacea extracts: Antioxidant activity and antihypertensive effects on L-NAME-induced hypertensive rats

Early and Late Cardiovascular and Metabolic Responses to Mixed Wine: Effect of Drink Temperature

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