Vasodilator action of the isopropyl ester of palmitoyl carnitine in the rat coronary circulation and mesenteric vascular bed

Criddle, David N.; Dewar, George H.; Woodward, Brian

doi:10.1016/0014-2999(94)90101-5

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…8 In the vasculature, palmitoyl-L-carnitine affects membrane fluidity and has been shown to cause diminished endothelium-dependent vasodilation, whereas the isopropyl ester of palmitoyl-L-carnitine causes vasodilation. 21,22 In the present study, we found that PLC caused vasodilation of human arteries that appeared to be mostly mediated by endothelial prostaglandin production. Given the differential effects of these various moieties, it would be interesting to compare the vasoactive effects of L-carnitine and its derivatives in these human arteries as well.…”

Section: Discussionsupporting

confidence: 57%

“…Along these lines, other investigators have found that another L-carnitine derivative, the iso- propyl ester of palmitoyl-L-carnitine, caused vasodilation of the coronary and mesenteric circulations that was shown to be caused by a direct effect on the smooth muscle. 21,22 The overall effect of L-carnitine and its derivatives appears to be moiety specific. For example, PLC increases the walking capacity of patients with claudication to a greater extent than L-carnitine.…”

Section: Discussionmentioning

confidence: 99%

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Propionyl-L-carnitine dilates human subcutaneous arteries through an endothelium-dependent mechanism

Cipolla

Nicoloff

Rebello

et al. 1999

Journal of Vascular Surgery

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Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Propionyl-L-carnitine dilates human subcutaneous arteries through an endothelium-dependent mechanism

Cipolla

Nicoloff

Rebello

et al. 1999

Journal of Vascular Surgery

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Lipid metabolism part I

Koltai¹,

Reshkin²,

Baltazar³

et al. 2021

Prostate Cancer Metabolism

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Structure-activity Relationships of Some Novel Coronary Dilator Derivatives of Palmitoyl Carnitine in the Rat Isolated Heart

Reeves

Dewar

Woodward

1996

Journal of Pharmacy and Pharmacology

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The structure-activity relationships of some novel coronary dilator derivatives of palmitoyl carnitine in the rat isolated perfused heart are described. It has been shown previously that esterification of palmitoyl carnitine changes the activity of the compound from a coronary constrictor to a coronary dilator. In this study, it was found that the ester group is not a necessary requirement for coronary dilator activity, but only the absence of the negatively charged carboxylic acid group of palmitoyl carnitine, as compounds containing an ethyl group in place of the ester group were also active coronary dilators. Furthermore, substituting the methyl groups attached to the nitrogen atom of the molecule profoundly altered coronary dilator activity. A quaternary ammonium group was a necessary requirement for potent coronary dilator activity.

show abstract

Vasodilator action of the isopropyl ester of palmitoyl carnitine in the rat coronary circulation and mesenteric vascular bed

Cited by 3 publications

References 23 publications

Propionyl-L-carnitine dilates human subcutaneous arteries through an endothelium-dependent mechanism

Propionyl-L-carnitine dilates human subcutaneous arteries through an endothelium-dependent mechanism

Lipid metabolism part I

Structure-activity Relationships of Some Novel Coronary Dilator Derivatives of Palmitoyl Carnitine in the Rat Isolated Heart

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