Vasodilatation by carbon dioxide and sodium nitroglycerin reduces compliance of the cerebral arteries in humans

Moir, M. Erin; Vermeulen, Tyler D.; Smith, S.; Woehrle, Emilie; Matushewski, Brad; Zamir, M.; Shoemaker, J. Kevin

doi:10.1113/ep089533

Cited by 8 publications

(5 citation statements)

References 42 publications

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“…These findings open up new facets of the pharmacodynamics of these drugs and expand the understanding of their effects on cerebral hemodynamics. And finally, in a recent clinical study on healthy volunteers 64 , it was shown that dilatation of the middle cerebral artery due to NTG administration was accompanied by a significant decrease in compliance of the downstream cerebral vasculature, which, logically, should lead to a decrease in the amplitude of blood pulsations in intra-parenchymal arterioles.…”

Section: Discussionmentioning

confidence: 99%

Duality in response of intracranial vessels to nitroglycerin revealed in rats by imaging photoplethysmography

Sokolov,

Volynsky,

Potapenko

et al. 2023

Sci Rep

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Among numerous approaches to the study of migraine, the nitroglycerin (NTG) model occupies a prominent place, but there is relatively insufficient information about how NTG affects intracranial vessels. In this study we aim to assess the effects of NTG on blood-flow parameters in meningeal vessels measured by imaging photoplethysmography (iPPG) in animal experiments. An amplitude of the pulsatile component (APC) of iPPG waveform was assessed before and within 2.5 h after the NTG administration in saline (n = 13) or sumatriptan (n = 12) pretreatment anesthetized rats in conditions of a closed cranial window. In animals of both groups, NTG caused a steady decrease in blood pressure. In 7 rats of the saline group, NTG resulted in progressive increase in APC, whereas decrease in APC was observed in other 6 rats. In all animals in the sumatriptan group, NTG administration was accompanied exclusively by an increase in APC. Diametrically opposite changes in APC due to NTG indicate a dual effect of this drug on meningeal vasomotor activity. Sumatriptan acts as a synergist of the NTG vasodilating action. The results we obtained contribute to understanding the interaction of vasoactive drugs in the study of the headache pathophysiology and methods of its therapy.

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Section: Discussionmentioning

confidence: 99%

Duality in response of intracranial vessels to nitroglycerin revealed in rats by imaging photoplethysmography

Sokolov,

Volynsky,

Potapenko

et al. 2023

Sci Rep

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“…Other associated parameters are sedation depth-related parameter BIS (Froese et al 2021), respiratory oscillations-related parameter GainFV (Haubrich et al 2015, Varsos et al 2015, thiopental treatment (Howells et al 2012), cerebral hemodynamic instability (Pineda et al 2018), pressure reactivity (Shahsavari et al 2011, Kim et al 2012, transfer function between ABP and ICP (Budohoski et al 2012), hyperventilation (Steiner et al 2005, Carrera et al 2011, CT-image (Zeiler et al 2018b), ICP spindle waves (Zhu et al 2023), phase shift angle between CBFV and ICP (Kim et al 2015), the resistance to CSF outflow (Kim et al 2009a), VMR (Haubrich et al 2013), hypocapnia-hypercapnia (Carrera et al 2011a, Haubrich et al 2013, supratentorial and infratentorial compartment (Moyse et al 2016), age (Kiening et al 2005), ultrasoundguided aspiration (Ng et al 2005), arterial hypertension (Kim et al 2012), plateau waves (Kim et al 2009b), CVR (Capel et al 2014), L/P ratio (Salci et al 2006), brain elasticity (Kim et al 2010), internal carotid artery disease (Carrera et al 2011b), and SNG and hypercapnia protocol (Moir et al 2021).…”

Section: Discussionmentioning

confidence: 99%

“…Another study was conducted on healthy subjects, experimenting with the effect of sublingual sodium nitroglycerin (SNG) protocol and hypercapnia protocol. In both cases, cerebrovascular compliance decreased, with hypercapnia protocol associated with a comparatively higher reduction (Moir et al 2021).…”

Section: Studies With Other Patient Patientsmentioning

confidence: 91%

“…Nine studies of this comprehensive systematic review included research that encompassed TCD-based continuous measurement of CC/CCR (Kim et al 2009b, 2010, Carrera et al 2011, 2011a, 2011b, Capel et al 2014, Kazimierska et al 2021, Moir et al 2021. Out of them, three focused on TBI patients (Kim et al 2009b, Carrera et al 2011, three researched patients with hydrocephalus (Kim et al 2010, Capel et al 2014, Kazimierska et al 2021, and two studied normal subjects (Carrera et al 2011a(Carrera et al , 2011b) and the remaining one involved patients with internal carotid artery disease (Moir et al 2021).…”

Section: Tcd-based Continuous Measurementmentioning

confidence: 99%

See 1 more Smart Citation

Continuous monitoring methods of cerebral compliance and compensatory reserve: a scoping review of human literature

Islam,

Froese,

Bergmann

et al. 2024

Physiol. Meas.

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Objective: Continuous monitoring of cerebrospinal compliance (CC)/ cerebrospinal compensatory reserve (CCR) is crucial for timely interventions and preventing more substantial deterioration in the context of acute neural injury, as it enables the early detection of abnormalities in intracranial pressure (ICP). However, to date, the literature on continuous CC/CCR monitoring is scattered and occasionally challenging to consolidate. Approach: We subsequently conducted a systematic scoping review of the human literature to highlight the available continuous CC/CCR monitoring methods.Main Results:This systematic review incorporated a total number of 76 studies, covering diverse patient types and focusing on three primary continuous CC or CCR monitoring metrics and methods – Moving Pearson’s correlation between ICP pulse amplitude waveform (AMP) and ICP, referred to as RAP, the Spiegelberg Compliance Monitor, changes in cerebral blood velocity (CBV) with respect to the alternation of ICP measured through Transcranial Doppler (TCD), changes in centroid metric, high frequency centroid (HFC) or higher harmonics centroid (HHC), and the P2/P1 ratio which are the distinct peaks of ICP pulse wave (ICPW). The majority of the studies in this review encompassed RAP metric analysis (n=43), followed by Spiegelberg Compliance Monitor (n=11), TCD studies (n=9), studies on the HFC/HHC (n=5), and studies on the P2/P1 ratio studies (n=6). These studies predominantly involved acute traumatic neural injury (i.e. Traumatic Brain Injury (TBI)) patients and those with hydrocephalus. RAP is the most extensively studied of the five focused methods and exhibits diverse applications. However, most papers lack clarification on its clinical applicability, a circumstance that is similarly observed for the other methods.Significance: Future directions involve exploring RAP patterns and identifying characteristics and artifacts, investigating neuroimaging correlations with continuous CC/CCR and integrating machine learning, holding promise for simplifying CC/CCR determination. These approaches should aim to enhance the precision and accuracy of the metric, making it applicable in clinical practice.

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“…Much like the rest of the body, the CNS vasculature responds to compounds such as nitroglycerin [14][15][16] and sodium nitroprusside, [17,18] which cause rapid vessel dilation. However, direct investigation of the effects of local blood flow modulation on the CNS tissues is difficult.…”

Section: Introductionmentioning

confidence: 99%

Electrically Controlled Vasodilator Delivery from PEDOT/Silica Nanoparticle Modulates Vessel Diameter in Mouse Brain

Woeppel,

Krahe,

Robbins

et al. 2023

Adv Healthcare Materials

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Vascular damage and reduced tissue perfusion are expected to majorly contribute to the loss of neurons or neural signals around implanted electrodes. However, there are limited methods of controlling the vascular dynamics in tissues surrounding these implants. This work utilizes conducting polymer poly(ethylenedioxythiophene) and sulfonated silica nanoparticle composite (PEDOT/SNP) to load and release a vasodilator, sodium nitroprusside, to controllably dilate the vasculature around carbon fiber electrodes (CFEs) implanted in the mouse cortex. The vasodilator release is triggered via electrical stimulation and the amount of release increases with increasing electrical pulses. The vascular dynamics are monitored in real‐time using two‐photon microscopy, with changes in vessel diameters quantified before, during, and after the release of the vasodilator into the tissues. This work observes significant increases in vessel diameters when the vasodilator is electrically triggered to release, and differential effects of the drug release on vessels of different sizes. In conclusion, the use of nanoparticle reservoirs in conducting polymer‐based drug delivery platforms enables the controlled delivery of vasodilator into the implant environment, effectively altering the local vascular dynamics on demand. With further optimization, this technology could be a powerful tool to improve the neural electrode‐tissue interface and study neurovascular coupling.

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Vasodilatation by carbon dioxide and sodium nitroglycerin reduces compliance of the cerebral arteries in humans

Cited by 8 publications

References 42 publications

Duality in response of intracranial vessels to nitroglycerin revealed in rats by imaging photoplethysmography

Duality in response of intracranial vessels to nitroglycerin revealed in rats by imaging photoplethysmography

Continuous monitoring methods of cerebral compliance and compensatory reserve: a scoping review of human literature

Electrically Controlled Vasodilator Delivery from PEDOT/Silica Nanoparticle Modulates Vessel Diameter in Mouse Brain

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