Vasoconstrictor Effects of Uridine and Its Nucleotides and Their Inhibition by Adenosine

Macdonald, Graham; Assef, Rhonda; Guiffre, A.; Lo, E.

doi:10.1111/j.1440-1681.1984.tb00283.x

Cited by 23 publications

(21 citation statements)

References 4 publications

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“…Uridine, UMP, and UDP had vasoconstrictor actions in the rat isolated perfused kidney (Macdonald et al, 1984). Up 4 A was claimed to act as a potent vasoconstrictor of the rat isolated perfused kidney via P2X 1 and P2Y 2 receptors, whereas endothelium-dependent vasodilation was mediated by P2Y 1 and P2Y 2 receptors (Tölle et al, 2010).…”

Section: Purinergic Signaling and Blood Vesselsmentioning

confidence: 99%

Purinergic Signaling and Blood Vessels in Health and Disease

2013

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Section: Purinergic Signaling and Blood Vesselsmentioning

confidence: 99%

Purinergic Signaling and Blood Vessels in Health and Disease

2013

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“…This probably explains the simultaneous decrease in systolic arterial blood pressure in our study. In contrast to this finding, MacDonald et al 16 found that intravenous UDP (0.0202-0.1616 mg/kg/min) may increase systolic arterial blood pressure when infused into intact anesthetized rats. This difference in blood pressure responses between studies can probably be accounted for by the dosage range and species differences.…”

Section: Resultsmentioning

confidence: 58%

Effect of uridine 5'-diphosphate on cryogenic brain edema in rabbits.

Yoshida

Alksne

Seelig

et al. 1989

Stroke

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This study was undertaken to examine the effect of uridine 5'-diphosphate, administered intravenously or intraperitoneally, on cold injury-induced brain edema in rabbits. Bolus injection or continuous intravenous infusion of uridine 5'-diphosphate 26 hours after a lesion was established had adverse effects, such as increased intracranial pressure and lowered systolic arterial blood pressure and cerebral perfusion pressure for approximately 10-29 minutes, but these parameters did not change appreciably from 29 minutes to 3 hours after administration. Intraperitoneally administered uridine 5'-diphosphate did not affect these parameters appreciably during 3 hours. Thus, the intravenous administration of uridine 5'-diphosphate is harmful under neurosurgical conditions. In contrast, 10 mg/kg/day i.p. uridine 5'-diphosphate pretreatment and posttreatment, beginning 24 hours before and continuing until 24 hours after the insult, significantly reduced neurologic abnormalities, Evans blue extravasation, water content in the injured gray matter, and intracranial pressure without affecting water content in the white matter. Intravenous dexamethasone pretreatment and posttreatment in this setting significantly reduced only neurologic abnormalities. However, there were no significant differences between intraperitoneal uridine 5-diphosphate and intravenous dexamethasone effects on cold-injured brain. {Stroke 1989;20:1694-1699) K atunuma, Kido, and colleagues 1 -5 showed that derivatives of uridine nucleotide sugar may amplify the many biologic functions of glucocorticoids, such as liver enzyme induction, cytotoxicity for lymphoblast cells in vivo and in vitro, anti-inflammatory mechanisms, and protection against the development of carrageenan edema in rabbit leg. We found that uridine 5'-diphosphate (UDP) may also be protective against the development of carrageenan edema in rabbit leg (S. Yoshida, unpublished data). These two observations suggest that exogenous UDP might also amplify the actions of endogenous glucocorticoids against brain edema. Therefore, this study was designed to examine the effects of 3 hours of UDP treatment on a wellestablished, 26-hour-old cold lesion to determine the appropriate route and method of UDP administration and then to compare the effects of intraperitoneal UDP and intravenous dexamethasone treat- Received May 12, 1988; accepted June 29, 1989. ment beginning 24 hours before and continuing to 24 hours after the insult on the evolution of pathologic changes in cold-injured brain. Materials and MethodsIn the delayed treatment experiment, 50 New Zealand White rabbits weighing 2.5-3.3 kg were anesthetized with 25 mg/kg i.v. sodium thiopental (Abbott Laboratories, North Chicago, Illinois) and positioned in a head frame. These rabbits were not pretreated with UDP (Sigma Chemical Co., St. Louis, Missouri). A 12.5-mm-diameter circular trephine hole was made over the left parietooccipital cortex using a standardized technique 6 in all 50 rabbits. The cold injury was induced in 38 rabbits when a r...

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“…In the absence of a mediator, the existence of such a system remains theoretical in spite of a mounting literature about its postulated characteristics. Uridine has previously been shown to elevate blood pressure and cause a natriuresis in the anaesthetized rat (Pessina & Macdonald 1980) and it became apparent that virtually all the properties ascribed to a hypertensive natriuretic factor, especially by de Wardener and MacCregor (1982), fitted a nucleotide compound. A personal communication from Morich, indicating that uridine is increased in the urine of salt-loaded hypertensive rats and inhibits rat erythrocyte Na+/K+ ATP-ase, made a study of natriuretic function of the uridine nucleotides even more relevant.…”

Section: Discussionmentioning

confidence: 98%

“…Uridine, uridine monophosphate (UMP) and uridine diphosphate (UDP) raise blood pressure in the intact rat when infused intravenously and increase the perfusion pressure in the isolated perfused rat kidney (Macdonald et al 1984). UMP and UDP also increase isometric work in the everted rat portal vein, an effect not seen with uridine.…”

Section: Introductionmentioning

confidence: 98%

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The Uridine Nucleotides Constitute a Natriuretic Pressor System

Macdonald

Assef

Watkins

et al. 1987

Clin Exp Pharma Physio

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1. Uridine monophosphate was tested in the conscious rat for natriuretic properties and an immunoperoxidase technique was used to localize uridine-containing compounds in the rat kidney. 2. Uridine monophosphate, infused in a moderate pressor dose, caused a significant natriuresis compared to the effect of control infusions of solvent vehicle. 3. Uridine-containing compounds were found in most tubular elements with particularly dense staining in the distal and collecting tubules. 4. While the increased sodium excretion may have been due to increased renal perfusion pressure, the high density of uridine staining in distal nephrons suggests that the uridine nucleotides have a specific nephron function, possibly relating to sodium transport.

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Vasoconstrictor Effects of Uridine and Its Nucleotides and Their Inhibition by Adenosine

Cited by 23 publications

References 4 publications

Purinergic Signaling and Blood Vessels in Health and Disease

Purinergic Signaling and Blood Vessels in Health and Disease

Effect of uridine 5'-diphosphate on cryogenic brain edema in rabbits.

The Uridine Nucleotides Constitute a Natriuretic Pressor System

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