Vasoactivity, antioxidant and aphrodisiac properties of Caesalpinia benthamiana roots

Zamblé, Alexis; Martin-Nizard, Françoise; Şahpaz, Sevser; Hennebelle, Thierry; Staels, Bart; Bordet, Régis; Duriez, Patrick; Brunet, C.; Bailleul, François

doi:10.1016/j.jep.2007.11.016

Cited by 27 publications

(16 citation statements)

References 36 publications

(35 reference statements)

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“…Quercetin has been reported to improve ED in diabetic rats induced with streptozotocin, this was accompanied by increased intracavernous pressure, endothelial NOS (eNOS), and improvement in the antioxidant status as evident by improved SOD activity and MDA levels in the CC of diabetic rats (Zhang et al, ). Gallic acid also enhanced sexual activity, antioxidant capacity, vasorelaxant properties, and stimulated the expression of endothelial NO synthase (eNOS) mRNA in endothelial cells of experimental male rats (Zamble et al, ). Furthermore, phenolic compounds have been reported to possess PDE‐5, arginase, ACE, and AChE inhibitory potentials due to their ability to form hydrogen bonds and their interactions between the hydrophobic active site of the enzymes (Akomolafe, Oboh, Oyeleye, & Boligon, ; Oboh et al, ).…”

Section: Resultsmentioning

confidence: 99%

Fluted pumpkin ( Telfairia occidentalis ) seed modulates some markers of erectile function in isolated rat’s corpus cavernosum: Influence of polyphenol and amino acid constituents

et al. 2019

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Pumpkin seeds are often used in traditional medicine in the management of erectile dysfunction. However, there is insufficient information about the possible biochemical rationale behind this practice. Hence, this study investigated the influence of fluted pumpkin seed on critical enzymes involved in erectile function in isolated rats’ corpus cavernosum in vitro. The phenolics and amino acid contents of fluted pumpkin seed were determined using HPLC‐DAD and GC‐PFPD analyses respectively. The aqueous extract of the fluted pumpkin seed significantly (p < .05) scavenged free radicals and inhibited PDE‐5, arginase, AChE, and ACE in rats’ corpus cavernosum in a concentration‐dependent pattern. Quercitrin and luteolin were the most dominant phenolics, while arginine, aspartate, and cysteine were the most aboundant amino acid constituents. The positive modulatory effect of the fluted pumpkin seed on these critical markers of erectile function could be attributed to its polyphenolics and amino acid constituents. Practical applications This study brought to limelight the medicinal importance of fluted pumpkin seed in erectile functions. Therefore, this seed could be used as a functional food ingredient in the management of erectile dysfunctions and also in improving erectile functions in men. In addition, the dominant phenolics and amino acid constituents of this seed might be an effective nutraceutical in enhancing erections in men.

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Section: Resultsmentioning

confidence: 99%

Fluted pumpkin ( Telfairia occidentalis ) seed modulates some markers of erectile function in isolated rat’s corpus cavernosum: Influence of polyphenol and amino acid constituents

et al. 2019

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“…Hydrogen peroxide scavenging activity was measured by using the modified method of peroxidase-dependent oxidation of phenol red (Zamblé et al, 2008). Trolox was used as a standard compound in the assay.…”

Section: Hydrogen Peroxide Scavenging Activitymentioning

confidence: 99%

Antioxidant and hepatoprotective activity of ethanol extract of Arachniodes exilis (Hance) Ching

Zhou¹,

Ruan²,

Cai³

et al. 2010

Journal of Ethnopharmacology

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“…Influence of keayanidine B and keayanine on the endothelial production of eNOS was measured by QPCR analysis according to a procedure described previously (Zamblé et al, 2008).…”

Section: Interaction With No By Qpcr and Cytotoxicitymentioning

confidence: 99%

“…Antioxidant and scavenging activities of keayanidine B and keayanine were assessed versus DPPH and ROS such as superoxide anion (O 2 •− ) and hydrogen peroxide (H 2 O 2 ) in cell-free and cellular systems. These tests were carried out according to the procedures described previously (Hennebelle et al, 2008;Zamblé et al, 2008). Results were expressed in IC 50 values (n = 6, medium value ± SD).…”

Section: Interaction With No By Qpcr and Cytotoxicitymentioning

confidence: 99%

“…Continuing our investigations on plants traditionally used in erectile dysfunction (Zamblé et al, 2008(Zamblé et al, , 2007a, this present work focuses on pharmacological studies of pure major alkaloids, keayanidine B and keayanine isolated from Microdesmis keayana J. Léonard. M. keayana is a West African tropical plant used widely in traditional medicine for many purposes.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Microdesmis keayana alkaloids on vascular parameters of erectile dysfunction

Zamblé

Martin-Nizard

Şahpaz

et al. 2008

Phytotherapy Research

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Microdesmis keayana (Pandaceae) is an African tropical plant whose roots are used in traditional medicine for erection impairment but the compounds responsible for its action are unknown. Two major alkaloids recently isolated from the roots of M. keayana, keayanidine B and keayanine, were tested for vasorelaxing properties using isolated rat aortic rings precontracted by phenylephrine to confirm its traditional use. Influence of the alkaloids on the endothelial production of endothelial nitric oxide synthase (eNOS) was measured by quantitative polymerase chain reaction (QPCR) analysis. Scavenging activities were assessed versus 1,1-diphenyl-2-picrylhydrazyle (DPPH) and reactive oxygen species (ROS) such as superoxide anion (O(2)(*-) and hydrogen peroxide (H(2)O(2)) in cell-free and cellular systems. The results showed that keayanidine B and keayanine had significant vasorelaxing properties. This effect could be due to their strong antioxidant activity versus O(2)(*-) and H(2)O(2) and to their stimulation of eNOS mRNA expression. Therefore these alkaloids could indirectly stimulate NO production in the vascular bed and would explain the traditional use of M. keayana in erectile dysfunction.

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Vasoactivity, antioxidant and aphrodisiac properties of Caesalpinia benthamiana roots

Cited by 27 publications

References 36 publications

Fluted pumpkin ( Telfairia occidentalis ) seed modulates some markers of erectile function in isolated rat’s corpus cavernosum: Influence of polyphenol and amino acid constituents

Fluted pumpkin ( Telfairia occidentalis ) seed modulates some markers of erectile function in isolated rat’s corpus cavernosum: Influence of polyphenol and amino acid constituents

Antioxidant and hepatoprotective activity of ethanol extract of Arachniodes exilis (Hance) Ching

Effects of Microdesmis keayana alkaloids on vascular parameters of erectile dysfunction

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