“…Quercetin has been reported to improve ED in diabetic rats induced with streptozotocin, this was accompanied by increased intracavernous pressure, endothelial NOS (eNOS), and improvement in the antioxidant status as evident by improved SOD activity and MDA levels in the CC of diabetic rats (Zhang et al, ). Gallic acid also enhanced sexual activity, antioxidant capacity, vasorelaxant properties, and stimulated the expression of endothelial NO synthase (eNOS) mRNA in endothelial cells of experimental male rats (Zamble et al, ). Furthermore, phenolic compounds have been reported to possess PDE‐5, arginase, ACE, and AChE inhibitory potentials due to their ability to form hydrogen bonds and their interactions between the hydrophobic active site of the enzymes (Akomolafe, Oboh, Oyeleye, & Boligon, ; Oboh et al, ).…”