Vasoactive intestinal polypeptide plasma levels associated with affective symptoms and brain structure and function in healthy females

Simon, Rozalyn; Barazanji, Nawroz; Jones, Michael; Bednarska, Olga; Icenhour, Adriane; Engström, Maria; Hamilton, J. Paul; Keita, Åsa V.; Walter, Susanna

doi:10.1038/s41598-020-80873-2

Cited by 6 publications

(2 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, PACAP −/− mice might exhibit a whole spectrum of behavioral disorders, depending on the initial source of stress, type and duration. In a clinical study, VIP serum levels negatively correlated with depression and anxiety state and positively correlated with brain volume of the left amygdala [106]. Similarly, decreased serum levels of VIP were detected in a rat depression model [107].…”

Section: Depression Anxiety and Bipolar Disordermentioning

confidence: 84%

Targeting the neurological comorbidities of multiple sclerosis: the beneficial effects of VIP and PACAP neuropeptides

Jansen¹,

Broome²,

Castorina³

2022

J. Integr. Neurosci.

View full text Add to dashboard Cite

Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclaseactivating polypeptide (PACAP) are two widely expressed neuropeptides with important immunomodulatory and neuroprotective properties in the central nervous system (CNS). Both VIP and PACAP have been implicated in several neurological diseases and have shown favourable e fects in di ferent animal models of multiple sclerosis (MS). MS is a chronic in lammatory and neurodegenerative disease of the CNS a fecting over 2.5 million people worldwide. The disease is characterised by extensive neuroin lammation, demyelination and axonal loss. Currently, there is no cure for MS, with treatment options only displaying partial e ficacy. Importantly, epidemiological studies in the MS population have demonstrated that there is a high incidence of neurological and psychological comorbidities such as depression, anxiety, epilepsy and stroke among a licted people. Hence, given the widespread protective e fects of the VIP/PACAP system in the CNS, this review will aim at exploring the beneficial roles of VIP and PACAP in ameliorating some of the most common neurological comorbidities associated with MS. The final scope of the review is to put more emphasis on how targeting the VIP/PACAP system may be an e fective therapeutic strategy to modify MS disease course and its associated comorbidities.

show abstract

Section: Depression Anxiety and Bipolar Disordermentioning

confidence: 84%

Targeting the neurological comorbidities of multiple sclerosis: the beneficial effects of VIP and PACAP neuropeptides

Jansen¹,

Broome²,

Castorina³

2022

J. Integr. Neurosci.

View full text Add to dashboard Cite

show abstract

“…Detection of VIP levels in human plasma 19 emerged as a valuable diagnostic and prognostic tool in rheumatic diseases, 11,20,21 affective disorders 22,23 and to monitor neuroendocrine tumors. 24 In pregnant women, the concentration of VIP in peripheral blood is about half its concentration in median arterial and venous umbilical cord blood whereas it is higher in plasma at labor than during pregnancy.…”

Section: Vip: Initially Described As Neurotransmitter Emerges As An I...mentioning

confidence: 99%

From decidualization to pregnancy progression: An overview of immune and metabolic effects of VIP

Ramhorst

Grasso

Vota

et al. 2022

American J Rep Immunol

View full text Add to dashboard Cite

Background A tight immune and metabolic regulation underlies the early maternal‐placental interaction to assist the energetic dynamic demands of the fetus throughout pregnancy. The vasoactive intestinal peptide (VIP) holds biochemical, metabolic and immune properties consistent with a regulatory role during pregnancy. Aim Here we overview critical aspects of embryo implantation and placental development with special focus on the immune and metabolic effects of VIP expressed by decidual and trophoblast cells. Content During decidualization, endometrial stromal cells undergo reticular stress and trigger unfolded protein response (UPR) that enable expansion of their endoplasmic reticulum and immunomodulatory factor synthesis. These processes appear differentially affected in recurrent abortion and in vitro fertilization failure suggesting their relevance in reproductive pathologies. Similarly, defective placentation associates with altered immune, vascular and trophoblast interaction resulting in complicated pregnancies that threaten maternal and neonatal health and underlie metabolic programming of adult life. We discuss the most recent research on decidual, trophoblast and immune cell interaction on the light of VIP regulation. Its role in decidualization and UPR associated with a sterile inflammatory response and angiogenesis is discussed. Evidence on VIP modulation of cytotrophoblast cell function, metabolism and immune profile is revised as well as the shaping of decidual leukocyte phenotype and function from decidualization to term. Implications The broad spectrum of effects of VIP from implantation to term in normal and pathological conditions summarized here might contribute to the identification of novel biomarkers for diagnosis and pharmacological targeting.

show abstract

Molecular characterization of depression trait and state

et al. 2021

View full text Add to dashboard Cite

Major Depressive disorder (MDD) is a chronic and recurrent brain disorder characterized by episode and remission phases, and poor therapeutic responses. The molecular correlates of MDD have been investigated in case-control settings, but the biological changes associated with trait (regardless of episode/remission) or state (illness phases) remains largely unknown, hence preventing therapeutic opportunities. To address this gap, we generated transcriptome profiles in the subgenual anterior cingulate cortex of MDD subjects who died during a single or recurrent episode or when in remission. We show that biological changes associated with MDD trait (inflammation, immune activation, reduced bioenergetics) are distinct from those associated with MDD phases or state (neuronal structure and function, neurotransmission). On the cell-type level, gene variability in subsets of GABAergic interneurons positive for corticotropin-releasing hormone, somatostatin or vasoactive-intestinal peptide was associated with MDD phases.Applying a probabilistic Bayesian network approach, we next show that gene modules enriched for immune system activation, cytokine response and oxidative stress, may exert causal roles across MDD phases. Finally, using a database of drug-induced transcriptome perturbations, we show that MDD-induced changes in putative causal pathways are antagonized by families of drugs associated with clinical response, including dopaminergic and monoaminergic ligands, and uncover potential novel therapeutic targets. Collectively, these integrative transcriptome analyses provide novel insight into cellular and molecular pathologies associated with trait and state MDD, and a method of drug discovery focused on disease-causing pathways.

show abstract

Vasoactive intestinal polypeptide plasma levels associated with affective symptoms and brain structure and function in healthy females

Cited by 6 publications

References 65 publications

Targeting the neurological comorbidities of multiple sclerosis: the beneficial effects of VIP and PACAP neuropeptides

Targeting the neurological comorbidities of multiple sclerosis: the beneficial effects of VIP and PACAP neuropeptides

From decidualization to pregnancy progression: An overview of immune and metabolic effects of VIP

Molecular characterization of depression trait and state

Contact Info

Product

Resources

About