Vasoactive intestinal polypeptide modulates the estradiol-induced prolactin surge by entraining oxytocin neuronal activity

Kennett, Jessica E.; Poletini, Maristela O.; Freeman, Marc E.

doi:10.1016/j.brainres.2007.12.061

Cited by 12 publications

(6 citation statements)

References 44 publications

(64 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Oxytocin is not produced by SCN neurones and therefore is not a direct SCN output; however, oxytocin neurones in the PVN probably are a direct target of SCN output. VIP receptors have been localised on oxytocin neurones in the PVN and oxytocin neurones in the PVN show a daily rhythm in their activity . Interestingly, systemically administered oxytocin agonists and antagonists that pass the blood–brain barrier affect light‐induced phase shifts and the daytime administration of oxytocin exerted stronger anti‐obesity effects than night‐time administered oxytocin .…”

Section: Discussionmentioning

confidence: 99%

Suprachiasmatic Nucleus Neuropeptides and Their Control of Endogenous Glucose Production

Foppen

Tan

Ackermans

et al. 2016

J Neuroendocrinology

View full text Add to dashboard Cite

Defective control of endogenous glucose production is an important factor responsible for hyperglycaemia in the diabetic individual. During the past decade, progressively more evidence has appeared indicating a strong and potentially causal relationship between disturbances of the circadian system and defects of metabolic regulation, including glucose metabolism. The detrimental effects of disturbed circadian rhythms may have their origin in disturbances of the molecular clock mechanisms in peripheral organs, such as the pancreas and liver, or in the central brain clock in the hypothalamic suprachiasmatic nuclei (SCN). To assess the role of SCN output per se on glucose metabolism, we investigated (i) the effect of several SCN neurotransmitters on endogenous glucose production and (ii) the effect of SCN neuronal activity on hepatic and systemic insulin sensitivity. We show that silencing of SCN neuronal activity results in decreased hepatic insulin sensitivity and increased peripheral insulin sensitivity. Furthermore, both oxytocin neurones in the paraventricular nucleus of the hypothalamus (PVN) and orexin neurones in the lateral hypothalamus may be important targets for the SCN control of glucose metabolism. These data further highlight the role of the central clock in the pathophysiology of insulin resistance.

show abstract

Section: Discussionmentioning

confidence: 99%

Suprachiasmatic Nucleus Neuropeptides and Their Control of Endogenous Glucose Production

Foppen

Tan

Ackermans

et al. 2016

J Neuroendocrinology

View full text Add to dashboard Cite

show abstract

“…In the supraoptic nucleus, oxytocin gene expression increases throughout the oestrous cycle before peaking on oestrus (53). Similarly, the number of oxytocin neurones expressing fos‐related antigen in the paraventricular and periventricular nuclei of oestradiol‐treated animals gradually rises across the day, peaking at approximately the same time as the oestradiol‐induced surge of prolactin, suggesting that oxytocin is modulated by oestradiol and may be stimulating prolactin secretion (54). Oxytocin immunoneutralisation or application of an oxytocin antagonist attenuates the pro‐oestrous and the oestradiol‐induced surges of prolactin (Table 1, criterion [3]) (27,30,31,55).…”

Section: Oxytocin and Ovarian Steroid‐induced Prolactin Secretionmentioning

confidence: 99%

Oxytocin: An Emerging Regulator of Prolactin Secretion in the Female Rat

Kennett

McKee

2012

J Neuroendocrinology

View full text Add to dashboard Cite

In the female rat, a complex interplay of both stimulatory and inhibitory hypothalamic factors controls the secretion of prolactin. Prolactin regulates a large number of physiological processes from immunity to stress. In the following review, we have chosen to focus on the control of prolactin secretion in the female rat in response to suckling, mating and ovarian steroids. In all three of these states, dopamine, released from neurones in the mediobasal hypothalamus, is a potent inhibitory signal regulating prolactin secretion. Early research has determined that the relief of dopaminergic tone is not enough to account for the full surge of prolactin secretion observed in response to the suckling stimulus, launching a search for possible prolactin-releasing factors. This research has since broadened to include searching for prolactin-releasing factors controlling prolactin secretion following mating or ovarian steroids. A great deal of literature has suggested that this prolactin-releasing factor may include oxytocin. Oxytocin receptors are present on lactotrophs. These oxytocin receptors respond to exogenous oxytocin and antagonism of endogenous oxytocin inhibits lactotroph activity. In addition, the pattern of oxytocin neuronal activity and oxytocin release correlate with the release of prolactin. Here we suggest that not only is oxytocin stimulating prolactin secretion, but we also hypothesize that prolactin secretion is controlled by a complex network of positive (oxytocin) and negative (dopamine) feedback loops. In the present review, we will discuss this literature and attempt to describe the circuitry we believe may be responsible for controlling prolactin secretion.

show abstract

“…This hypothesis receives strong support and the spatial analysis focused our attention on an area defined by a population of vasoactive intestinal polypeptide (VIP) neurons. VIP neurons, fibers, and receptors are found in virtually every brain region that is known to be important for social behavior (22)(23)(24)(25), but with the exception of the VIP neuronal populations in the suprachiasmatic nucleus and tuberal hypothalamus, which regulate circadian rhythms and prolactin release, respectively (26,27), we know very little about the behavioral functions of VIP cell groups and their projection systems.…”

mentioning

confidence: 99%

An aggression-specific cell type in the anterior hypothalamus of finches

Goodson

Kelly

Kingsbury

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

The anterior hypothalamus (AH) is a major integrator of neural processes related to aggression and defense, but cell types in the AH that selectively promote aggression are unknown. We here show that aggression is promoted in a very selective and potent manner by dorsal AH neurons that produce vasoactive intestinal polypeptide (VIP). Fos activity in a territorial finch, the violet-eared waxbill (Estrildidae: Uraeginthus granatina) is positively related to aggression in the dorsal AH, overlapping a population of VIP-producing neurons. VIP is known to promote territorial aggression in songbirds, and thus we used antisense oligonucleotides to selectively block AH VIP production in male and female waxbills. This manipulation virtually abolishes aggression, reducing the median number of displacements in a 3-min resident-intruder test from 38 in control subjects to 0 in antisense subjects. Notably, most antisense and control waxbills exhibit an agonistic response such as a threat or agonistic call within 2 s of intrusion. Thus, antisense subjects clearly classify intruders as offensive, but fail to attack. Other social and anxiety-like behaviors are not affected and VIP cell numbers correlate positively with aggression, suggesting that these cells selectively titrate aggression. Additional experiments in the gregarious zebra finch (Estrildidae: Taeniopygia guttata) underscore this functional specificity. Colony-housed finches exhibit significant reductions in aggression (primarily nest defense) following AH VIP knockdown, but no effects are observed for social preferences, pair bonding, courtship, maintenance behaviors, or anxiety-like behaviors. To our knowledge, these findings represent a unique identification of an aggression-specific cell type in the brain.neuropeptide | reproduction T he anterior hypothalamus (AH) is a hub of neural processes related to aggression and agonistic communication in taxa ranging from fish to mammals (1-9). The AH is strongly interconnected with the ventrolateral subnucleus of the ventromedial hypothalamus (VMHvl) (10), and both areas are overlapped by the "hypothalamic attack area," a region from which aggressive behavior is elicited by electrical stimulation in mammals (7,9,11,12). A comparable organization is found in birds, as demonstrated by both electrical stimulation (1, 8) and immediate early gene expression (13,14). The AH and VMHvl integrate information from many socially relevant forebrain regions and project to midbrain areas that regulate motivation and motor processes (10,(15)(16)(17). However, whereas recent studies in male mice show that overlapping but distinct neuronal populations of the VMHvl regulate fighting and mating (18), the neurochemical phenotypes of aggression-related neurons in the VMHvl and AH are largely unknown (7). AH vasopressin neurons that promote aggression in voles also influence affiliation (5), and the AH further regulates stress response and defense (12,14,19). Thus, the identification of AH neurons that selectively promote aggression requires t...

show abstract

Vasoactive intestinal polypeptide modulates the estradiol-induced prolactin surge by entraining oxytocin neuronal activity

Cited by 12 publications

References 44 publications

Suprachiasmatic Nucleus Neuropeptides and Their Control of Endogenous Glucose Production

Suprachiasmatic Nucleus Neuropeptides and Their Control of Endogenous Glucose Production

Oxytocin: An Emerging Regulator of Prolactin Secretion in the Female Rat

An aggression-specific cell type in the anterior hypothalamus of finches

Contact Info

Product

Resources

About