Vasoactive intestinal polypeptide levels in sigmoid colon in idiopathic constipation and diverticular disease

Milner, P.; Crowe, R.; Kamm, Michael A.; Lennard‐Jones, J. E.; Burnstock, Geoffrey

doi:10.1016/0016-5085(90)90953-x

Cited by 122 publications

(71 citation statements)

References 21 publications

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“…These abnormalities include a deficiency of a peptide known as SP, which is thought to contribute to peristalsis (29). Disturbances in the normal neural content of VIP in the bowel wall in idiopathic constipation and diverticulosis may initiate or contribute to the functional changes observed in these disorders (30).…”

Section: Discussionmentioning

confidence: 99%

Preventive Effect of <i>Lactobacillus fermentum</i> Zhao on Activated Carbon-Induced Constipation in Mice

Qian

Suo

et al. 2015

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryThe aim of this study was to investigate the effects of Lactobacillus fermentum Zhao (LF-Zhao) on activated carbon-induced constipation in ICR mice. ICR mice were administered lactic acid bacteria by gavage for 9 d. Body weight, diet intake, drinking amount, stool status, gastrointestinal transit distance and stool time, in addition to motilin (MTL), gastrin (Gas), endothelin (ET), somatostatin (SS), acetylcholinesterase (AChE), substance P (SP) and vasoactive intestinal peptide (VIP) levels in serum were monitored to evaluate the preventive effects of LF-Zhao on constipation. Bisacodyl, a laxative drug, was used as a positive control. Times to the first black stool for normal (untreated), control (no lactic acid bacteria treatment but activated carbon treated), bisacodyl-treated and L. delbrueckii subsp. bulgaricus (LB), LF-Zhao (L) (low concentration of 1310 8 CFU/mL)-and LF-Zhao (H) (high concentration of 1310 9 CFU/mL)-treated mice induced by activated carbon were 90, 218, 117, 180, 169 and 156 min, respectively. Following the consumption of LB, LF-Zhao (L) and LFZhao (H) or the oral administration of bisacodyl, the gastrointestinal transit distances were reduced by 55.2%, 61.3%, 70.6% and 94.6%, respectively. The serum levels of MTL, Gas, ET, AChE, SP and VIP were significantly increased and the serum levels of SS were reduced in the mice treated with LF-Zhao compared with those in the control mice (p,0.05). These results demonstrated that lactic acid bacteria demonstrate preventive effects on mouse constipation and that LF-Zhao alleviated constipation symptoms better than LB.

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Section: Discussionmentioning

confidence: 99%

Preventive Effect of <i>Lactobacillus fermentum</i> Zhao on Activated Carbon-Induced Constipation in Mice

Qian

Suo

et al. 2015

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…Anatomical studies on the regular innervation of the intestine in humans have revealed the presence of VIPergic neurons in submucous plexuses and myenteric plexuses of the small and large intestine [2][3][4]24]. Similar studies carried out on animals have shown also the presence of VIP-ergic neurons in both the small and in the large intestine [25][26][27][28].…”

Section: Discussionmentioning

confidence: 99%

“…The presence of NPY-ergic neurons has been found in the myenteric plexus and the presence of a small number of NPYergic nerve fibres has also been observed in the in the submucous and the myenteric plexuses [1,2,4,36]. NPY-ergic innervation in animals is better recognised.…”

Section: Discussionmentioning

confidence: 99%

“…Studies published so far have shown a lack of changes in NPY-ergic innervation of the large intestine wall in humans in such pathological conditions as: diverticulosis and idiopathic constipation [2,39]. On the other hand, some changes have been observed in Crohn's disease; these changes consist of an increase in the number of NPY-ergic neurons and density of NPY-ergic nerve fibres in the myenteric plexus of the small intestine [13].…”

Section: Discussionmentioning

confidence: 99%

“…In physiological conditions, within components of the enteric nervous system supplying the human large intestine, the presence of the following neuropeptides has been found: vasoactive intestinal peptide (VIP), neuropeptide Y (NPY) and pituitary adenylate cyclaseactivating polypeptide (PACAP) [1][2][3][4][5]. It is known that these neuropeptides are neurotransmitters and neuromodulators of the enteric nervous system.…”

Section: Introductionmentioning

confidence: 99%

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Changes in vasoactive intestinal peptide, pituitary adenylate cyclase-activating polypeptide and neuropeptide Y-ergic structures of the enteric nervous system in the carcinoma of the human large intestine.

Godlewski

Łakomy²

2010

Folia Histochem Cytobiol.

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This investigation was aimed at immunohistochemical analysis of potential changes in the enteric nervous system caused by cancer of the large intestine. In this purpose, neurons and nerve fibers of intestinal plexuses containing neuropeptides: vasoactive intestinal peptide (VIP), pituitary adenylate cyclase-activating polypeptide (PACAP) and neuropeptide Y (NPY), in pathologically changed part of the large intestine were microscpically observed and compared. Samples were taken from patients operated due to cancer of the sigmoid colon and rectum. The number of neurons and density of nerve fibres containing neuropeptides found in sections with cancer tissues were compared to those observed in sections from the uninvolved intestinal wall. Changes relating to reductions in the number of NPY-ergic neurons and density of nerve fibres in submucous and myenteric plexuses in the sections with cancer tissues (pathological sections) were statistically significant. A statistically similar presence of VIP-ergic and PACAP-ergic neurons in the submucosal and myenteric plexuses was observed in both the pathological and control sections. On the other hand, in the pathological sections, VIP-ergic nerve fibres in the myenteric plexuses and PACAP-ergic nerve fibres in the submucosal and myenteric plexuses were found to be less dense. Analysis revealed changes in pathologically affected part of the large intestine may caused disruption of proper intestinal function. Observed changes in the neural elements which are responsible for relaxation of the intestine may suggest dysfunction in the innervation of this part of the colon.

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Electric Activity of the Colon in Subjects With Constipation Due to Total Colonic Inertia

Shafik

Shafik²,

El-Sibai³

et al. 2003

Arch Surg

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Background: Idiopathic constipation may result from colonic inertia, which affects the whole colon or is localized to an area of the colon. The colon exhibits electric activity in the form of slow waves or pacesetter potentials (PPs) and action potentials (APs), which are coupled with elevated colonic pressure. The APs are claimed to be responsible for colonic motor activity. Hypothesis: Colonic electric activity is disordered in patients with constipation due to colonic inertia. Methods: Electric activity was studied in 11 patients with colonic inertia and constipation (mean±SD age, 42.8±6.6 years; 7 women) who underwent total colectomy. Eight volunteers who had no gastrointestinal complaints (mean±SD age, 40.6 ± 5.8 years; 5 women) acted as controls. Control subjects underwent laparotomy for hernia repair (n=7 patients) and for removal of a mesenteric cyst (n = 1 patient). During the operation, 2 monopolar silver-silver chloride electrodes were applied to the cecum and the ascending, transverse, descending, and sigmoid colon. Results: Electric waves (PPs and APs) were recorded from all parts of the colon in control subjects. The waves were See Invited Critique at end of article

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Vasoactive intestinal polypeptide levels in sigmoid colon in idiopathic constipation and diverticular disease

Cited by 122 publications

References 21 publications

Preventive Effect of <i>Lactobacillus fermentum</i> Zhao on Activated Carbon-Induced Constipation in Mice

Preventive Effect of <i>Lactobacillus fermentum</i> Zhao on Activated Carbon-Induced Constipation in Mice

Changes in vasoactive intestinal peptide, pituitary adenylate cyclase-activating polypeptide and neuropeptide Y-ergic structures of the enteric nervous system in the carcinoma of the human large intestine.

Electric Activity of the Colon in Subjects With Constipation Due to Total Colonic Inertia

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