Vasoactive intestinal peptide (VIP) and VIP receptors: Gene expression and growth modulation in medulloblastoma and other central primitive neuroectodermal tumors of childhood

Frühwald, Michael C.; O’Dorisio, M. Sue; Fleitz, Julie; Pietsch, Torsten; Reubi, Jean Claude

doi:10.1002/(sici)1097-0215(19990412)81:2<165::aid-ijc1>3.0.co;2-0

Cited by 28 publications

(10 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Research to date suggests that VIPR1 has a role in cell differentiation (18). Its upregulation suppresses tumorigenicity in certain cell lines (18,19) and an immunohistochemical approach showed weaker immunostaining of VIPR1 in prostate cancer than in normal epithelial cells (20). These findings are also supported by an immunohistochemistry approach, in which VIPR1 was observed in the majority of normal human epithelial tissues, including the lung.…”

Section: Discussionmentioning

confidence: 73%

Oligonucleotide DNA Microarray Profiling of Lung Adenocarcinoma Revealed Significant Downregulation and Deletions of Vasoactive Intestinal Peptide Receptor 1

Mlakar

Stražišar

Sok

et al. 2009

Cancer Investigation

View full text Add to dashboard Cite

The purpose of this study was to find novel gene(s) involved in the development of lung adenocarcinoma (AD). Using DNA microarrays, we identified 31 up-regulated and 8 downregulated genes in 12 AD. Real time PCR was used to measure expression of VIPR1 and SPP1 mRNA and possible losses or gains of genes in 32 AD. We describe significant upregulation of the SPP1 gene, downregulation of VIPR1, and losses of the VIPR1 gene. Our findings complement a proposed VIPR1 tumor suppressor role, in which deletions in the 3p22 chromosome region are an important mechanism leading to loss of the VIPR1 gene.

show abstract

Section: Discussionmentioning

confidence: 73%

Oligonucleotide DNA Microarray Profiling of Lung Adenocarcinoma Revealed Significant Downregulation and Deletions of Vasoactive Intestinal Peptide Receptor 1

Mlakar

Stražišar

Sok

et al. 2009

Cancer Investigation

View full text Add to dashboard Cite

show abstract

“…are one of the most frequent groups of CNS malignant tumors[144]. In one study[144], 86% of the central primitive neuroectodermal tumors had VPAC1 mRNA and 75% VPAC2 mRNA.…”

Section: Vip/pacap: Central-nervous-system-tumors(cns-tumors)mentioning

confidence: 99%

“…are one of the most frequent groups of CNS malignant tumors[144]. In one study[144], 86% of the central primitive neuroectodermal tumors had VPAC1 mRNA and 75% VPAC2 mRNA. Furthermore, the addition of VIP to 10 primitive neuroectodermal tumor cell-lines inhibited growth in 70%[144].…”

Section: Vip/pacap: Central-nervous-system-tumors(cns-tumors)mentioning

confidence: 99%

Vasoactive intestinal peptide/pituitary adenylate cyclase activating polypeptide, and their receptors and cancer

Moody¹,

Nuche-Berenguer

Jensen

2016

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

View full text Add to dashboard Cite

Purpose of review To summarize the roles of VIP/PACAP and their receptors(VPAC1, VPAC2/PAC1) in human tumors as well as their role in potential novel treatments. Recent findings Considerable progress has been made in understanding of the effects of VIP/PACAP on growth of various tumors as well as in the signaling cascades involved, especially of the role of transactivation of the Epidermal growth factor(EGF) family. The overexpression of VPAC1/2, PAC1 on a number of common neoplasms (breast, lung, prostate, CNS, neuroblastoma) is receiving increased attention both as a means of tumor imaging the location and extent of these tumors, as well as for targeted directed treatment, by coupling cytotoxic agents to VIP/PACAP analogues. Summary VIP/PACAP has prominent growth effects on a number of common neoplasms, which frequently overexpressed the three subtypes of their receptors. The increased understanding of their signaling cascades, effect on tumor growth/differentiation, and the use of the overexpression of these receptors for localization/targeted cytotoxic delivery, are all suggesting possible novel tumor treatments.

show abstract

“…In various tumor cell lines, VIP has a role in modulation of cell growth, differentiation and specific cell function [see, e.g. 4,12,14,20,32,37,48].…”

Section: Nerve Tissuementioning

confidence: 99%

Nerve fibers in tumors of the human urinary bladder

2001

View full text Add to dashboard Cite

Abstract. Exophytic tumors of the urinary bladder were examined by means of transmission electron microscopy for the presence of neural tissue because, as yet, there has been hardly any discussion of a neuronal component in the biology of neoplasms. In the stroma and rarely in the epithelium of bladder tumors, fine nerve strands were found to be irregularly distributed. These strands comprised one to a maximum of five axons containing predominantly colocalized clear and dense-core vesicles. Immunohistochemistry revealed some nerve-like structures showing vasoactive intestinal neuropeptide (VIP) reactivity. This response and the combination of vesicle types indicate that parasympathetic cholinergic neurons contribute to the innervation of the tumors. Thus, a morphological basis for neuronal influence on the behavior of such tumors has been demonstrated.

show abstract

Vasoactive intestinal peptide (VIP) and VIP receptors: Gene expression and growth modulation in medulloblastoma and other central primitive neuroectodermal tumors of childhood

Cited by 28 publications

References 20 publications

Oligonucleotide DNA Microarray Profiling of Lung Adenocarcinoma Revealed Significant Downregulation and Deletions of Vasoactive Intestinal Peptide Receptor 1

Oligonucleotide DNA Microarray Profiling of Lung Adenocarcinoma Revealed Significant Downregulation and Deletions of Vasoactive Intestinal Peptide Receptor 1

Vasoactive intestinal peptide/pituitary adenylate cyclase activating polypeptide, and their receptors and cancer

Nerve fibers in tumors of the human urinary bladder

Contact Info

Product

Resources

About