Vasoactive Intestinal Peptide Secreting Tumors of Childhood

Kaplan, Saul J.; Holbrook, C. Tate; McDaniel, Huey G.; Buntain, William L.; Crist, William M.

doi:10.1001/archpedi.1980.02130130013005

Cited by 24 publications

(21 citation statements)

References 18 publications

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“…]-his syndrome has been linked to an excess secretion of vasoactive intestinal peptides (VIP) as well as catecholamines [40]. Elevated VIP levels may occur in as many as 25% of patients with neuroblastoma; therefore, many children do not have this clinical syndrome despite excess VIP secretion [40,59].…”

Section: Clinicalmentioning

confidence: 99%

Imaging of neuroblastoma: an overview

1986

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Section: Clinicalmentioning

confidence: 99%

Imaging of neuroblastoma: an overview

1986

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“…In adults, the WDHA syndrome has been described in a variety of tumours, but mostly in vipomas originating from the pancreas [73]. In children, VIP production causing WDHA has been associated predominantly with neural crest tumours [21,36,90]; vipoma of the pancreas has been reported only once [11]. The intractable diarrhoea of patients with neural crest tumours was previously believed to be due to excessive catecholamine production, but is now known to be caused by VIP production by tumour cells.…”

Section: Watery Diarrhoea Hypokalaemia and Achlorhydriamentioning

confidence: 99%

“…The intractable diarrhoea of patients with neural crest tumours was previously believed to be due to excessive catecholamine production, but is now known to be caused by VIP production by tumour cells. The WDHA syndrome in children has been reported in neuroblastomas, but mostly in ganglioneuroblastomas and ganglioneuromas [17,21,36,40,69]. The WDHA syndrome in children has been reported in neuroblastomas, but mostly in ganglioneuroblastomas and ganglioneuromas [17,21,36,40,69].…”

Section: Watery Diarrhoea Hypokalaemia and Achlorhydriamentioning

confidence: 99%

“…We include this syndrome in this review because VIP production by neural crest tumours is currently considered as ectopic, although recent evidence suggests that VIP may play a role in the normal sympathetic nervous system [65]. The symptoms of the WDHA include profuse watery diarrhoea and hypokalaemia, preceding the diagnosis of the neural crest tumour in most cases [21,36,69]. The symptoms of the WDHA include profuse watery diarrhoea and hypokalaemia, preceding the diagnosis of the neural crest tumour in most cases [21,36,69].…”

Section: Watery Diarrhoea Hypokalaemia and Achlorhydriamentioning

confidence: 99%

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Paraneoplastic manifestations in children

Graaf¹,

Tamminga²,

Kamps³

1994

Eur J Pediatr

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Paraneoplastic manifestations are signs and symptoms observed in patients with cancer, distant from the tumour or its metastases and not caused by invasion, obstruction or bulk mass. In children with cancer, paraneoplastic manifestations are rare and distinct from those observed in adults. Knowledge about paraneoplastic manifestations can be of great clinical importance because they may be the presenting sign of a tumour or its recurrence and hence facilitate early diagnosis. In contrast, they sometimes mask the symptoms of a tumour and cause diagnostic delay. In this review, paraneoplastic manifestations in children are described, including hypercalcaemia, Cushing syndrome, precocious puberty, opsoclonus/myoclonus, acquired von Willebrand disease, watery diarrhoea syndrome, and hypertension. The mechanisms causing these manifestations are also discussed.

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“…Since the diarrhoea ceases after tumour removal it seems likely that a humoral substance secreted by the tumour is responsible. Since then a number of case reports on chronic diarrhoea associated with elevated concentration of VIP in plasma and tumour tissue extract in children with NCT have been published (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). Since then a number of case reports on chronic diarrhoea associated with elevated concentration of VIP in plasma and tumour tissue extract in children with NCT have been published (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14).…”

mentioning

confidence: 99%

Vasoactive Intestinal Polypeptide (Vip) in Children With Neural Crest Tumours

Scheibel¹,

Rechnitzer²,

Fahrenkrug³

et al. 1982

Acta Paediatrica

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The concentration of vasoactive intestinal polypeptide (VIP) in plasma was measured in 22 children with neural crest tumours (NCT) during a 5-year period; the mean concentration of VIP in plasma was 22.5 pmol/l (interval 2.0-95.0 pmol/l). To establish a reference interval the plasma concentration of VIP was measured in 41 children without tumours; the mean concentration of VIP in plasma was 6.2 pmol/l (interval 0.5-19.0 pmol/l). Of the 22 children with NCT 16 had a plasma concentration of VIP within the normal range while 6 children (27%) had elevated plasma concentration of VIP between 28 and 95 pmol/l. Only one child, whose plasma concentration of VIP was 95 pmol/l had diarrhoea. Elevated plasma concentration of VIP in children with NCT but no diarrhoea has not previously been described. The urinary excretion of vanillylmandelic acid (VMA) was increased in 18 of the children with NCT (82%). In 2 of the children with normal excretion of VMA the concentration of VIP in plasma was elevated. Thus, the plasma concentration of VIP may be a supplement to VMA as a tumour marker in some cases of NCT.

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Vasoactive Intestinal Peptide Secreting Tumors of Childhood

Abstract: \s=b\A 2-year-old boy with failure to thrive, watery diarrhea, abdominal distention,

Cited by 24 publications

References 18 publications

Imaging of neuroblastoma: an overview

Imaging of neuroblastoma: an overview

Paraneoplastic manifestations in children

Vasoactive Intestinal Polypeptide (Vip) in Children With Neural Crest Tumours

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