Vasoactive intestinal peptide represses activation of tumor-associated macrophages in gastric cancer via regulation of TNFα, IL-6, IL-12 and iNOS

Chen, Lu; Yuan, Weijie; Chen, Zhikang; Wu, Shaobin; Ge, Jie; Chen, Jinxiang; Chen, Zihua

doi:10.3892/ijo.2015.3126

Cited by 22 publications

(14 citation statements)

References 38 publications

(59 reference statements)

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“…Meanwhile, the widely distributed vasoactive intestinal peptide and the pituitary adenylate cyclase-activating polypeptide (PACAP) downregulate macrophage-derived production of numerous pro-inflammatory molecules, whereas inducing macrophage synthesis of the anti-inflammatory mediators IL-4 and IL-10 ( 71 – 73 ). Overall, neuropeptides are able to modulate macrophage-dependent activities and promote body homeostasis in conditions as diverse as recovering injured nerve tissue, restraining tumor progression or preventing HIV-1 production ( 72 , 74 , 75 ).…”

Section: Neurotransmitters and Hormones Regulate Macrophage Functionmentioning

confidence: 99%

Neuroendocrine Control of Macrophage Development and Function

et al. 2018

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Macrophages carry out numerous physiological activities that are essential for both systemic and local homeostasis, as well as innate and adaptive immune responses. Their biology is intricately regulated by hormones, neuropeptides, and neurotransmitters, establishing distinct neuroendocrine axes. The control is pleiotropic, including maturation of bone marrow-derived myeloid precursors, cell differentiation into functional subpopulations, cytotoxic activity, phagocytosis, production of inflammatory mediators, antigen presentation, and activation of effector lymphocytes. Additionally, neuroendocrine components modulate macrophage ability to influence tumor growth and to prevent the spreading of infective agents. Interestingly, macrophage-derived factors enhance glucocorticoid production through the stimulation of the hypothalamic–pituitary–adrenal axis. These bidirectional effects highlight a tightly controlled balance between neuroendocrine stimuli and macrophage function in the development of innate and adaptive immune responses. Herein, we discuss how components of neuroendocrine axes impact on macrophage development and function and may ultimately influence inflammation, tissue repair, infection, or cancer progression. The knowledge of the crosstalk between macrophages and endocrine or brain-derived components may contribute to improve and create new approaches with clinical relevance in homeostatic or pathological conditions.

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Section: Neurotransmitters and Hormones Regulate Macrophage Functionmentioning

confidence: 99%

Neuroendocrine Control of Macrophage Development and Function

et al. 2018

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“…These include pheochromocytomas[63, 165], gastric-cancer[166, 167•], cervical-cancer[168], choriocarcinoma-cells[169], neuroendocrine-tumors[60•, 62, 170] and renal-cancer[59, 171•, 172]. …”

Section: Vip/pacap: Other Tumorsmentioning

confidence: 99%

Vasoactive intestinal peptide/pituitary adenylate cyclase activating polypeptide, and their receptors and cancer

Moody¹,

Nuche-Berenguer

Jensen

2016

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

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Purpose of review To summarize the roles of VIP/PACAP and their receptors(VPAC1, VPAC2/PAC1) in human tumors as well as their role in potential novel treatments. Recent findings Considerable progress has been made in understanding of the effects of VIP/PACAP on growth of various tumors as well as in the signaling cascades involved, especially of the role of transactivation of the Epidermal growth factor(EGF) family. The overexpression of VPAC1/2, PAC1 on a number of common neoplasms (breast, lung, prostate, CNS, neuroblastoma) is receiving increased attention both as a means of tumor imaging the location and extent of these tumors, as well as for targeted directed treatment, by coupling cytotoxic agents to VIP/PACAP analogues. Summary VIP/PACAP has prominent growth effects on a number of common neoplasms, which frequently overexpressed the three subtypes of their receptors. The increased understanding of their signaling cascades, effect on tumor growth/differentiation, and the use of the overexpression of these receptors for localization/targeted cytotoxic delivery, are all suggesting possible novel tumor treatments.

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“…These findings indicate that the positive association of COX-2 with meningioma represents a potential area for therapeutic intervention with selective COX-2 inhibitors, either as an adjunct or in combination with radiation therapy. The final molecule predicted is IL-6, which belongs to the chemotactic cytokine family and correlates with occurrence, invasion, and metastasis of cancer [ 44 ]. Recent evidence suggests that, of the proinflammatory cytokines, IL-6 is a central player linking chronic inflammation to cancer by driving tumor initiation and subsequent growth and metastasis.…”

Section: Discussionmentioning

confidence: 99%

Identification of a Transcription Factor-microRNA-Gene Coregulation Network in Meningioma through a Bioinformatic Analysis

Wang

Liang

Yang

et al. 2020

BioMed Research International

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Background. Meningioma is a prevalent type of brain tumor. However, the initiation and progression mechanisms involved in the meningioma are mostly unknown. This study aimed at exploring the potential transcription factors/micro(mi)RNAs/genes and biological pathways associated with meningioma. Methods. mRNA expressions from GSE88720, GSE43290, and GSE54934 datasets, containing data from 83 meningioma samples and eight control samples, along with miRNA expression dataset GSE88721, which had 14 meningioma samples and one control sample, were integrated analyzed. The bioinformatics approaches were used for identifying differentially expressed genes and miRNAs, as well as predicting transcription factor targets related to the differentially expressed genes. The approaches were also used for gene ontology term analysis and biological pathway enrichment analysis, construction, and analysis of protein-protein interaction network, and transcription factor-miRNA-gene coregulation network construction. Results. Fifty-six upregulated and 179 downregulated genes were identified. Thirty transcription factors able to target the differentially expressed genes were predicted and selected based on public databases. One hundred seventeen overlapping genes were identified from the differentially expressed genes and the miRNAs predicted by miRWalk. Furthermore, NF-κB/IL6, PTGS2, MYC/hsa-miR-574-5p, hsa-miR-26b-5p, hsa-miR-335-5p, and hsa-miR-98-5p, which are involved in the transcription factor-miRNA-mRNA coregulation network, were found to be associated with meningioma. Conclusion. The bioinformatics analysis identified several potential molecules and relevant pathways that may represent critical mechanisms involved in the progression and development of meningioma. This work provides new insights into meningioma pathogenesis and treatments.

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Vasoactive intestinal peptide represses activation of tumor-associated macrophages in gastric cancer via regulation of TNFα, IL-6, IL-12 and iNOS

Cited by 22 publications

References 38 publications

Neuroendocrine Control of Macrophage Development and Function

Neuroendocrine Control of Macrophage Development and Function

Vasoactive intestinal peptide/pituitary adenylate cyclase activating polypeptide, and their receptors and cancer

Identification of a Transcription Factor-microRNA-Gene Coregulation Network in Meningioma through a Bioinformatic Analysis

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