Vasectomy and Risk of Prostate Cancer: A Systematic Review and Meta-analysis

Baboudjian, Michael; Rajwa, Paweł; Barret, Éric; Beauval, Jean-Baptiste; Brureau, Laurent; Créhange, G.; Dariane, C.; Fiard, G.; Fromont, Gaëlle; Gauthé, Mathieu; Mathiéu, Romain; Renard-Penna, Raphaële; Roubaud, Guilhem; Ruffion, A.; Sargos, P.; Rouprêt, Morgan; Ploussard, Guillaume

doi:10.1016/j.euros.2022.04.012

Cited by 6 publications

(2 citation statements)

References 52 publications

(59 reference statements)

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“…Vasectomy has been discussed as a putative risk factor for PCa development over recent decades, and some studies have supported an association with lethal PCa 6,7 . The conclusion was further reinforced by two systematic reviews 8,9 . However, some recent studies found either no or only a weak association between vasectomy and overall PCa risk (closer to the null with increasingly robust study design), 10–14 finally resulting in currently strong evidence rebutting a relationship between vasectomy and PCa 7 …”

Section: Introductionmentioning

confidence: 99%

“…6,7 The conclusion was further reinforced by two systematic reviews. 8,9 However, some recent studies found either no or only a weak association between vasectomy and overall PCa risk (closer to the null with increasingly robust study design), [10][11][12][13][14] finally resulting in currently strong evidence rebutting a relationship between vasectomy and PCa. 7 Screening for PCa using prostate-specific antigen (PSA) has added complexity to epidemiological studies of the disease.…”

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confidence: 99%

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Vasectomy and risk of prostate cancer: A Mendelian randomization study and confounder analysis

Di,

Wen

2023

The Prostate

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BackgroundPrevious reports have shown a potential causal impact of vasectomy on prostate cancer (PCa). The objective of this study was to investigate the association between vasectomy and PCa, while evaluating the influence of confounding factors such as prostate‐specific antigen (PSA) screening and body mass index (BMI).MethodsMendelian randomization (MR) study using summary statistics from genome‐wide associations of vasectomy (462,933 European ancestry), ever had PSA test (200,410 European ancestry), time since last PSA test (46,104 European ancestry), BMI (152,893 European males) and PCa (79,148 cases, 61,106 controls, European ancestry). This study was conducted using summary statistic data from large, previously described cohorts. Data analyses were conducted from November 2022 to June 2023.ResultsGenetic liability to vasectomy was not associated with PCa (OR = 0.07, 95% CI: 2.95 10−3, 1.54, p = 0.09). Genetic liability to vasectomy was not associated with ever had PSA test (OR = 1.08, 95% CI: 0.49−2.39, p = 0.83) and time since last PSA test (OR = 2.49, 95% CI: 0.71−8.79, p = 0.16). After controlling for PSA test and BMI, there remains no causal relationship between vasectomy and PCa risk (OR = 5.56 10−4, 95% CI: 7.29 10−8, 4.24, p = 0.10). The reverse MR results showed a weak association between PCa and vasectomy patients (OR = 1.00, 95% CI: 1.0003−1.0033, p = 0.02).ConclusionBased on the available evidence from MR analysis, the current findings did not support vasectomy being a risk factor for PCa. Further work is required to provide additional confirmation and validation of the potential link.

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