Vasectomy and cardiovascular disease risk

Abstract

Background:Even though several studies comparing vasectomy and cardiovascular disease (CVD) risk have been reported, most are small series with conflicting results. However, the extent of the risk is still uncertain. We therefore explored whether an association exists between vasectomy and CVD incidence and mortality.Methods:We searched PubMed, Embase, Web of Science, and Cochrane Library databases for relevant studies published before January 2017. Multivariate adjusted odds ratio (OR) and associated 95% confidence intervals (CIs) and those by subgroups were extracted and pooled using random-effects models.Results:Overall, 12 observational studies (2 cross-sectional studies, 4 case–control studies, and 6 retrospective cohort studies) comprising 299,436 participants were identified. There was no statistically significant relationship between vasectomy and CVD risk (OR: 0.90, 95% CI: 0.81–1.00). Moreover, vasectomy was not associated with CVD mortality (OR: 0.90, 95% CI: 0.81–1.00), coronary heart disease (CHD) incidence (OR: 0.94, 95% CI: 0.88–1.01), stroke incidence (OR: 0.90, 95% CI: 0.72–1.13), and myocardial infarction (MI) incidence (OR: 0.95, 95% CI: 0.88–1.02), with no significant publication bias. In subgroup analyses, the findings on the association between vasectomy and CVD risk were consistent.Conclusion:Our findings suggest that vasectomy is not associated with the excess risk of CVD incidence and mortality. Nevertheless, large-volume, well-designed observational studies, with different ethnic populations, low risk of bias, and adjusted confounding factors, are awaited to confirm and update the findings of this analysis.

Review of Vasectomy Complications and Safety Concerns

“…Bhatia et al [ 69 ] reported substantial increases in serum levels of cholesterol and triglycerides in rabbits that had undergone a vasectomy. However, a large number of studies have confirmed (including Clarkson's research) that there is no association between vasectomy and cardiovascular disease or related factors (even if the time after surgery exceeds 20 years) ( Table 3 ) [ 40 68 70 71 72 73 74 75 76 77 ]. These factors include body mass index, cholesterol, triglycerides, protein, albumin and high-density lipoprotein levels, and the ratio of globulin.…”

Superexpressão Gênica PTEN em Tecidos Miocárdicos de Pacientes de Cirurgia de Revascularização Miocárdica

“…Doenças cardiovasculares (DCV), como doença arterial coronariana (DAC), infarto do miocárdio (IM) e acidente vascular cerebral, são causas significativas de mortalidade e morbidade na população em geral em todo o mundo. 2 A DAC é a causa mais comum de morte no mundo entre as doenças cardiovasculares. O PTEN tem um papel crítico na hipertrofia e sobrevida dos cardiomiócitos.…”

“…Cardiovascular diseases (CVD), such as coronary artery disease (CAD), myocardial infarction (MI), and stroke are significant causes of mortality and morbidity in the general population worldwide. 2 CAD is the most common cause of death worldwide among cardiovascular diseases. PTEN plays a critical role in cardiomyocyte hypertrophy and survival.…”

“…Uma das causas mais comuns de morte em homens e mulheres em todo o mundo são as doenças cardiovasculares, 1 e uma das mais importantes é a doença arterial coronariana (DAC), que é afetada por muitos fatores. 2 Fatores genéticos, bem como fatores ambientais, desempenham um papel essencial nas DAC. 3 O mecanismo genético subjacente não é totalmente compreendido, mas estima-se que a herança possa ter uma efetividade de 40 a 60% na doença arterial coronariana.…”

“…One of the most common causes of death in men and women worldwide is cardiovascular disease, 1 and one of the most important of these is coronary artery disease (CAD), which is affected by many factors. 2 Genetic factors, as well as environmental factors, play an essential role in CAD. 3 The underlying genetic mechanism is not fully understood, but it is estimated that 40-60% inheritance may be effective in coronary artery disease.…”