Vasculogenesis in Diabetes-Associated Diseases: Unraveling the Diabetic Paradox

Costa, Carla

doi:10.5772/25903

Cited by 2 publications

(1 citation statement)

References 139 publications

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“…Several studies have presented a decrease in vascular progenitors in diabetic PB [Murata et al, ; Saito et al, ; Westerweel et al, ; Maiorino et al, ], whereas, others have shown an increase in these cell populations [Fadini et al, ; Liu et al, ; Flammer et al, ]. This relates to the so‐called diabetic angiogenic paradox [Costa, ]. Decreased cEPCs were reported in diabetes challenged with: ischemia, wound healing, coronary, and peripheral artery disease [Fadini et al, ; Gallagher et al, ; De Falco et al, ; Antonio et al, ].…”

Section: Discussionmentioning

confidence: 99%

Vasculogenesis and Diabetic Erectile Dysfunction: How Relevant Is Glycemic Control?

Castela

Gomes

Silvestre

et al. 2016

J of Cellular Biochemistry

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Erectile dysfunction (ED) is a complication of diabetes, condition responsible for causing endothelial dysfunction (EDys) and hampering repair mechanisms. However, scarce information is available linking vasculogenesis mediated by Endothelial Progenitor Cells (EPCs) and diabetes-associated ED. Furthermore, it remains to be elucidated if glycemic control plays a role on EPCs functions, EPCs modulators, and penile vascular health. We evaluated the effects of diabetes and insulin therapy on bone marrow (BM) and circulating EPCs, testosterone, and systemic/penile Stromal Derived Factor-1 alpha (SDF-1α) expression. Male Wistar rats were divided into groups: age-matched controls, 8-weeks streptozotocin-induced type 1 diabetics, and insulin-treated 8-weeks diabetics. EPCs were identified by flow cytometry for CD34/CD133/VEGFR2/CXCR4 antigens. Systemic SDF-1α and testosterone levels were evaluated by ELISA. Penile SDF-1α protein expression was assessed, in experimental and human diabetic cavernosal samples, by immunohistochemical techniques. Diabetic animals presented a reduction of BM-derived EPCs and an increase in putative circulating endothelial cells (CECs) sloughed from vessels wall. These alterations were rescued by insulin therapy. In addition, glycemic control promoted an increase in systemic testosterone and SDF-1α levels, which were significantly decreased in animals with diabetes. SDF-1α protein expression was reduced in experimental and human cavernosal diabetic samples, an effect prevented by insulin in treated animals. Insulin administration rescued the effects of diabetes on BM function, CECs levels, testosterone, and plasmatic/penile SDF-1α protein expression. This emphasizes the importance of glycemic control in the prevention of diabetes-induced systemic and penile EDys, by the amelioration of endothelial damage, and increase in protective pathways. J. Cell. Biochem. 118: 82-91, 2017. © 2016 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 99%

Vasculogenesis and Diabetic Erectile Dysfunction: How Relevant Is Glycemic Control?

Castela

Gomes

Silvestre

et al. 2016

J of Cellular Biochemistry

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Hypoxia in Vascular Networks: A Complex System Approach to Unravel the Diabetic Paradox

et al. 2014

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In this work we model the extent of hypoxia in the diabetic retina as a function of the area affected by vessel disruption. We find two regimes that differ on the ratio between the area of disrupted vasculature and the area of tissue in hypoxia. In the first regime the hypoxia is localized in the vicinity of the vascular disruption, while in the second regime there is a generalized hypoxia in the affected tissue. The transition between these two regimes occurs when the tissue area affected by individual sites of vessel damage is on the order of the square of the characteristic irrigation length in the tissue (the maximum distance that an irrigated point in the tissue is from an existing vessel). We observe that very high levels of hypoxia are correlated with the rupture of larger vessels in the retina, and with smaller radii of individual sites of vessel damage. Based on this property of vascular networks, we propose a novel mechanism for the transition between the nonproliferative and the proliferative stages in diabetic retinopathy.

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Vasculogenesis in Diabetes-Associated Diseases: Unraveling the Diabetic Paradox

Cited by 2 publications

References 139 publications

Vasculogenesis and Diabetic Erectile Dysfunction: How Relevant Is Glycemic Control?

Vasculogenesis and Diabetic Erectile Dysfunction: How Relevant Is Glycemic Control?

Hypoxia in Vascular Networks: A Complex System Approach to Unravel the Diabetic Paradox

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