Vasculitis in primary vasculitides, granulomatoses, and connective tissue diseases

Wegener's granulomatosis autoantibodies identify a novel diisopropylfluorophosphate-binding protein in the lysosomes of normal human neutrophils.

“…All patients' sera had been submitted to our laboratory for routine ANCA testing. Sera from 41 patients with a diagnosis of WG, established in the referring hospitals on the basis of histopathological findings and/or classical clinical symptoms (21), were selected. These sera contained significant titers of ANCA, producing the characteristic C-ANCA in the standard ANCA immunofluorescence test (IFT); i.e., indirect immunofluorescence on ethanol-fixed, air-dried cytospins of normal donor leukocytes (10).…”

Nomenclature of Systemic Vasculitides

“…Great effort was made to adopt names and definitions that are already widely accepted, especially those advocated in published articles concerning approaches to vasculitis nomenclature (see refs. [2][3][4][5][6][7][8].…”

Diagnosis of limited ophthalmic wegener granulomatosis: distinctive pathologic features with ANCA test confirmation

“…McCluskey and Feinberg observed that independent areas of extravascular necrotizing granulomatous lesions account for much of the tissue destruction, especially in pulmonary disease [25]. Purely granulomatous disease (without classic vasculitis) has been proposed as an early and sometimes the only manifestation of WG [24,26].…”