Vasculitic Neuropathy

Usefulness of superficial peroneal nerve/peroneus brevis muscle biopsy in the diagnosis of vasculitic neuropathy

“…Of these, the sural nerve is most commonly biopsied for diagnosis. 1,7,[26][27][28] Its sensitivity in suspected cases of vasculitis varies from 20% 9,10 to 50% in different studies. 6,10,14,19 Although a randomized control study has not been undertaken, several studies have recommended using combined SPN/PBM biopsy (Table 3).…”

“…Despite the development of newer, non-invasive serological tests for a wide range of auto-antibodies, diagnosis of vasculitis neuropathy often relies on pathological demonstration of vasculitis in involved peripheral nerves suitable for biopsy. [1][2][3] Histological evaluation of the sural nerve is most often used for diagnosis. Several studies have examined the sensitivity of sural nerve biopsy in the diagnosis of vasculitic neuropathy.…”

Always Keep in Mind the Neurological Complications of Connective Tissue Diseases-Review

“…Connective tissue diseases cover a wide range group of multisystem inflammatory disorders of muscle, joints, and skin often sharing the common feature of vasculitis [1][2][3]. Both immune mediated changes in the vasculature and ischemia of the vessels walls, as a hallmark of vasculitis, are the main causes of symptoms of the central nervous system (CNS) and peripheral nervous system (PNS).…”

Eosinophilic Granulomatosis with Polyangitis (Churg Strauss Syndrome) presenting as Guillain Barre Syndrome (GBS)- A Case Report

“…(1,2,(3)(4)(5)(6) The neuropathy is caused mainly by nerve ischemia due to occlusion of vasa nervorum. The American College of Rheumatology (ACR) has proposed six criteria for the diagnosis of Churg Strauss syndrome (7) .…”

“…The presence of four or more criteria yields a sensitivity of 85% and a specificity of 99.7%. These criteria include (1) asthma (wheezing, expiratory rhonchi), (2) eosinophilia of more than 10% in peripheral www.jmscr.igmpublication. Case Report 57 year old male, with history of well controlled Bronchial Asthma presented with 3 weeks history of progressive weakness of both lower and upper limbs.…”