Vasculite cérébrale secondaire à une infection à VZV

Outteryck, Olivier; Sénéchal, Olivier; Berteloot, D.; Delalande, I; Mounier‐Véhier, F.

doi:10.1016/s0035-3787(05)85144-6

Cited by 14 publications

(1 citation statement)

References 8 publications

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“…Viral infections could themselves cause, by direct invasion or by acting as a trigger, an inflammatory cascade with endothelial dysfunction, apoptosis, vasoconstriction, and subsequent ischaemia, tissue oedema, and procoagulant state [4]. For example, PCNSV onset has been related to previous infection with various microorganisms such as varicella zoster virus [5], West Nile virus [6], hepatitis B and C [7], human immunodeficiency virus [8], and herpesviruses [9]. More specifically, a link has been demonstrated with viruses belonging to the coronaviruses family, such as the Middle East respiratory syndrome-related coronavirus (MERS).…”

Section: Introductionmentioning

confidence: 99%

Isolated Central Nervous System Vasculitides in COVID-19: A Systematic Review of Case Reports and Series

Vecchio

Moretto

Padelli

et al. 2022

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Cerebral vasculitides, both isolated or in systemic disorders, could be triggered by infections, and few cases have been associated to coronavirus disease 2019 (COVID-19). This study searched for publications in Pubmed, EMBASE, and Cochrane library databases for case reports and series of isolated central nervous system (CNS) vasculitides triggered by severe acute respiratory syndrome coronavirus-2. We included 12 studies (published from June 2020 to July 2022) and collected 39 adult patients (5/39 pathologically or radiologically proven, 34/39 suggestive for primary CNS vasculitis or PCNSV). All cases had a positive real-time polymerase chain reaction on a nasopharyngeal swab or a respiratory tract specimen. About the 85% of the included cases were males, and disease onset occurred later than 50 years old in all but three subjects. In total, 33/39 patients presented severe COVID-19 pneumonia, frequently requiring intensive care unit care. The most common neurological features were headache, obnubilation, and coma. PCNSV was suspected mainly on radiological findings, whereas the cerebrospinal fluid analysis was minimally altered. Magnetic resonance imaging showed vessel wall enhancement in 32/39 cases, generally with the concomitant presence of microbleeds, subarachnoid haemorrhages, and/or multiple ischemic lesions. Despite the severe respiratory and neurological disease course, most cases (93%) improved spontaneously or after a course of high-dose intravenous steroids with no need for immunosuppression. In conclusion, PCNSV could rarely relate to COVID-19 and independently from pulmonary disease severity. Adults with COVID-19-related PCNSV could have a favourable prognosis.

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Section: Introductionmentioning

confidence: 99%

Isolated Central Nervous System Vasculitides in COVID-19: A Systematic Review of Case Reports and Series

Vecchio

Moretto

Padelli

et al. 2022

Reports

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Varicella zoster virus meningo-encephalo-myelitis in an immunocompetent patient

et al. 2008

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Objective-To describe clinical, MRI and cerebrospinal fluid (CSF) features of a varicella zoster virus (VZV) related meningo-encephalo-myelitis (MEM) without rash in an immunocompetent female. Conclusion-We highlight the importance of considering the possibility of VZV related MEM, even in immunocompetent patients. We also provide a MRI description of VZV related multifocal myelitis, not previously available. As supported by other reports, we underline the necessity of a prompt therapeutic intervention in this life-threatening condition Patient-An

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