Vascularizing organogenesis: Lessons from developmental biology and implications for regenerative medicine

Daniel, Edward; Cleaver, Ondine

doi:10.1016/bs.ctdb.2018.12.012

Cited by 28 publications

(27 citation statements)

References 146 publications

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“…spatially restrict PDGFRβ expression patterns to cortical domains of the kidney, leading to renal vascular stabilization (Hurtado et al, 2015;Daniel and Cleaver, 2019). Finally, perivascular macrophages in the nephrogenic zone interact with newly forming renal vessels and promote vascular anastomoses.…”

Section: Endothelial Migration and Patterning During Renal Vascular Dmentioning

confidence: 99%

Cellular and Molecular Mechanisms of Kidney Development: From the Embryo to the Kidney Organoid

Rad

Aghdami

Moghadasali

2020

Front. Cell Dev. Biol.

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Development of the metanephric kidney is strongly dependent on complex signaling pathways and cell-cell communication between at least four major progenitor cell populations (ureteric bud, nephron, stromal, and endothelial progenitors) in the nephrogenic zone. In recent years, the improvement of human-PSC-derived kidney organoids has opened new avenues of research on kidney development, physiology, and diseases. Moreover, the kidney organoids provide a three-dimensional (3D) in vitro model for the study of cell-cell and cell-matrix interactions in the developing kidney. In vitro recreation of a higher-order and vascularized kidney with all of its complexity is a challenging issue; however, some progress has been made in the past decade. This review focuses on major signaling pathways and transcription factors that have been identified which coordinate cell fate determination required for kidney development. We discuss how an extensive knowledge of these complex biological mechanisms translated into the dish, thus allowed the establishment of 3D human-PSC-derived kidney organoids.

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Section: Endothelial Migration and Patterning During Renal Vascular Dmentioning

confidence: 99%

Cellular and Molecular Mechanisms of Kidney Development: From the Embryo to the Kidney Organoid

Rad

Aghdami

Moghadasali

2020

Front. Cell Dev. Biol.

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“…[28] At a later stage during organ vascularization, they further differentiate to adapt to the needs of the organ. [25] Due to the specific environmental cues and epigenetic modifications, ECs in different organs acquire phenotypic heterogeneity. [27,29] These phenotypic variations, as characterized by transcriptional and protein expression profiles, lead to their differences in vasculature functionality such as barrier function and responses to drugs or cytokines.…”

Section: Selection Of Ecs For Vasculaturementioning

confidence: 99%

“…Although it is known that vasculature exhibits organ‐specific heterogeneity, the transcriptional programs that define the heterogeneity in each organ are not well understood . There is also an unmet demand for a suitable tool to further understand the mechanisms that control the establishment of the EC organotypic variations.…”

Section: The In Vivo Conditionmentioning

confidence: 99%

“…As the cells progress through the vasculature remodeling, they acquire specific characteristics of either arteries, veins, or lymphatics . At a later stage during organ vascularization, they further differentiate to adapt to the needs of the organ . Due to the specific environmental cues and epigenetic modifications, ECs in different organs acquire phenotypic heterogeneity .…”

Section: Design Consideration: How Simple Is Complex Enough?mentioning

confidence: 99%

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Recreating Physiological Environments In Vitro: Design Rules for Microfluidic‐Based Vascularized Tissue Constructs

Tan

Leung

2020

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Vascularization of engineered tissue constructs remains one of the greatest unmet challenges to mimicking the native tissue microenvironment in vitro. The main obstacle is recapitulating the complexity of the physiological environment while providing simplicity in operation and manipulation of the model. Microfluidic technology has emerged as a promising tool that enables perfusion of the tissue constructs through engineered vasculatures and precise control of the vascular microenvironment cues in vitro. The tunable microenvironment includes i) biochemical cues such as coculture, supporting matrix, and growth factors and ii) engineering aspects such as vasculature engineering methods, fluid flow, and shear stress. In this systematic review, the design considerations of the microfluidic‐based in vitro model are discussed, with an emphasis on microenvironment control to enhance the development of next‐generation vascularized engineered tissues.

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“…Although the types of stromal cells are slightly different for each organ, they generally include fibroblasts, neural cells, immune cells and vascular cells. They are known to have a profound effect on an organ through immune responses, nutrient supply, paracrine signaling and extracellular matrix supply [9][10][11][12] . Thus, including these cell types during organoid culture is important for increasing the maturity and complexity of organoids 13 .…”

Section: Introductionmentioning

confidence: 99%

Gastrointestinal tract modeling using organoids engineered with cellular and microbiota niches

2020

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The recent emergence of organoid technology has attracted great attention in gastroenterology because the gastrointestinal (GI) tract can be recapitulated in vitro using organoids, enabling disease modeling and mechanistic studies. However, to more precisely emulate the GI microenvironment in vivo, several neighboring cell types and types of microbiota need to be integrated into GI organoids. This article reviews the recent progress made in elucidating the crosstalk between GI organoids and components of their microenvironment. We outline the effects of stromal cells (such as fibroblasts, neural cells, immune cells, and vascular cells) on the gastric and intestinal epithelia of organoids. Because of the important roles that microbiota play in the physiology and function of the GI tract, we also highlight interactions between organoids and commensal, symbiotic, and pathogenic microorganisms and viruses. GI organoid models that contain niche components will provide new insight into gastroenterological pathophysiology and disease mechanisms.

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Vascularizing organogenesis: Lessons from developmental biology and implications for regenerative medicine

Cited by 28 publications

References 146 publications

Cellular and Molecular Mechanisms of Kidney Development: From the Embryo to the Kidney Organoid

Cellular and Molecular Mechanisms of Kidney Development: From the Embryo to the Kidney Organoid

Recreating Physiological Environments In Vitro: Design Rules for Microfluidic‐Based Vascularized Tissue Constructs

Gastrointestinal tract modeling using organoids engineered with cellular and microbiota niches

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