Vascularized organoid-on-a-chip: design, imaging, and analysis

Yu, Tingting; Yang, Qihang; Peng, Bo; Gu, Zhongze; Zhu, Dan

doi:10.1007/s10456-024-09905-z

Cited by 2 publications

(1 citation statement)

References 192 publications

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“…The advancement of OOC has led to the integration of vascularization into in vitro organoids on chips (Figure A). Vascularized OOC offers a more physiologically relevant in vitro system, particularly in the vascularization of liver-on-a-chip, lung-on-a-chip, and heart-on-a-chip, which is vital for drug screening and personalized medicine …”

Section: Vascularized Organ-on-a-chipmentioning

confidence: 99%

From Organ-on-a-Chip to Human-on-a-Chip: A Review of Research Progress and Latest Applications

Huang,

Liu,

Huang

et al. 2024

ACS Sens.

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Organ-on-a-Chip (OOC) technology, which emulates the physiological environment and functionality of human organs on a microfluidic chip, is undergoing significant technological advancements. Despite its rapid evolution, this technology is also facing notable challenges, such as the lack of vascularization, the development of multiorgan-on-a-chip systems, and the replication of the human body on a single chip. The progress of microfluidic technology has played a crucial role in steering OOC toward mimicking the human microenvironment, including vascularization, microenvironment replication, and the development of multiorgan microphysiological systems. Additionally, advancements in detection, analysis, and organoid imaging technologies have enhanced the functionality and efficiency of Organs-on-Chips (OOCs). In particular, the integration of artificial intelligence has revolutionized organoid imaging, significantly enhancing high-throughput drug screening. Consequently, this review covers the research progress of OOC toward Human-on-achip, the integration of sensors in OOCs, and the latest applications of organoid imaging technologies in the biomedical field.

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Section: Vascularized Organ-on-a-chipmentioning

confidence: 99%

From Organ-on-a-Chip to Human-on-a-Chip: A Review of Research Progress and Latest Applications

Huang,

Liu,

Huang

et al. 2024

ACS Sens.

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Targeted Cancer Therapy‐on‐A‐Chip

Abed,

Radha,

Anjum

et al. 2024

Adv Healthcare Materials

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Targeted cancer therapy (TCT) is gaining increased interest because it reduces the risks of adverse side effects by specifically treating tumor cells. TCT testing has traditionally been performed using two‐dimensional (2D) cell culture and animal studies. Organ‐on‐a‐chip (OoC) platforms have been developed to recapitulate cancer in vitro, as cancer‐on‐a‐chip (CoC), and used for chemotherapeutics development and testing. This review explores the use of CoCs to both develop and test TCTs, with a focus on three main aspects, the use of CoCs to identify target biomarkers for TCT development, the use of CoCs to test free, un‐encapsulated TCTs, and the use of CoCs to test encapsulated TCTs. Despite current challenges such as system scaling, and testing externally triggered TCTs, TCToC shows a promising future to serve as a supportive, pre‐clinical platform to expedite TCT development and bench‐to‐bedside translation.

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Vascularized organoid-on-a-chip: design, imaging, and analysis

Cited by 2 publications

References 192 publications

From Organ-on-a-Chip to Human-on-a-Chip: A Review of Research Progress and Latest Applications

From Organ-on-a-Chip to Human-on-a-Chip: A Review of Research Progress and Latest Applications

Targeted Cancer Therapy‐on‐A‐Chip

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