Vascularized Composite Allotransplant in the Realm of Regenerative Plastic Surgery

Chim, Harvey; Amer, Hatem; Mardini, Samir; Moran, Steven L.

doi:10.1016/j.mayocp.2014.05.009

Cited by 27 publications

(15 citation statements)

References 83 publications

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“…2). Of note, the majority of regenerative medicine clinical trials are still at an early stage of development focused on demonstration of feasibility and safety and early indication of efficacy with few reaching at this point the later stages of pivotal clinical trial validation [28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45].…”

Section: Service Line Build-outmentioning

confidence: 99%

Regenerative Medicine Build-Out

Terzic¹,

Pfenning

Gores

et al. 2015

Stem Cells Translational Medicine

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Section: Service Line Build-outmentioning

confidence: 99%

Regenerative Medicine Build-Out

Terzic¹,

Pfenning

Gores

et al. 2015

Stem Cells Translational Medicine

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“…Face transplantation (FT) is a promising advance in regenerative and restorative surgery, involving vascularised composite allotransplantation which transfers living tissue from a donor to a recipient including skin, bone, muscle, tendon and nerves 1. A recent issue of FT for patients who are blind has emerged.…”

Section: Introductionmentioning

confidence: 99%

Face transplantation for the blind: more than being blind in a sighted world

Lee

2018

J Med Ethics

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Face transplantation (FT) is a landmark in reconstructive surgery involving vascularised composite allotransplantation. a recent issue of FT for patients who are blind has arisen. Some bioethicists recommend not excluding a patient who is blind, as this may amount to discrimination. From an ethical standpoint, FT for those with blindness is appropriate in selected candidates. This article seeks to add to the clinical evidence supporting FT for those with blindness by detailing a complementary psychosocial perspective. Currently, there is little relevant research about the subjectivity of the blind. This is critical since the arguments against FT for the blind refer to their inability to see their face and to view the reaction of others to their disfigured faces. We begin with a brief look at examples of FT involving blindness and associated arguments. The next part is a multidisciplinary investigation of the experiences of the blind. These are gleaned from a close reading of the literature and drawing inferences, as direct studies are rare. The discussion analyses identity themes of the blind in relation to their faces: as they experience it; the face they wish to show to the world; and how others perceive and react to their face in a saturated environment of imagery and visual communication. Disability and the blind person's experience of faces are well-founded considerations for medical practitioners and ethics boards in the process of FT decision-making.

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“…1 There has been variable return of motor and sensory function following VCA, which is ultimately dependent on the success of nerve regeneration. [2][3][4] Strategies to improve peripheral nerve regeneration are paramount to this field. This review discusses the current knowledge and practices in the field of peripheral nerve regeneration.…”

Section: Introductionmentioning

confidence: 99%

Advances in peripheral nerve regeneration as it relates to VCA

Suchyta

Sabbagh

Morsy

et al. 2016

Vascularized Composite Allotransplantation

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Vascularized composite allotransplant (VCA) offers functional, social, and quality of life improvements for patients who have exhausted traditional reconstructive options. Unlike solid organ transplant, VCA success is not only based upon the quality of perfusion and level of immunosuppression, but also on the success of nerve regeneration within the transplanted part. This paper will summarize the present state of peripheral nerve regeneration in the context of VCA and will explore the latest research advances that will affect the future of the field. These advances offer promising future strategies to improve patient outcomes in VCA.

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Vascularized Composite Allotransplant in the Realm of Regenerative Plastic Surgery

Cited by 27 publications

References 83 publications

Regenerative Medicine Build-Out

Regenerative Medicine Build-Out

Face transplantation for the blind: more than being blind in a sighted world

Advances in peripheral nerve regeneration as it relates to VCA

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