Vascularized bone graft from the supracondylar region of the femur

Doi, Kazuteru; Hattori, Yasunori

doi:10.1002/micr.20671

Cited by 87 publications

(63 citation statements)

References 11 publications

(9 reference statements)

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“…Free VBGs from the iliac crest and the medial femoral supracondylar region have also been reported. 16,17 Pedicled vascularized grafts from the dorsal distal radius have been offered as a treatment option for displaced proximal pole fractures, AVN of the proximal fragments, established nonunions, and scaphoid nonunions that have failed nonvascularized bone grafting. 3,18 The use of a pedicled dorsal distal radial graft has the benefits of the anatomic reliability of the dorsal vascular network, relatively straightforward dissection, not having to perform vascular anastomoses, and the ability to limit dissection to a single surgical incision.…”

Section: Historical Perspectivementioning

confidence: 99%

2,3 Intercompartmental Supraretinacular Artery Pedicled Vascularized Bone Graft for Scaphoid Nonunions

Tan

Tu²

2013

Techniques in Hand &Amp; Upper Extremity Surgery

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Scaphoid nonunion is a complex problem that may continue to exist despite conventional methods of bone grafting and internal fixation. Vascularized bone grafting has been proposed as a treatment option for scaphoid nonunions with or without avascular necrosis of the proximal pole. Zaidemberg and colleagues first introduced the dorsal distal radius graft that has gained considerable popularity in the past 2 decades. Less commonly, the 2,3 intercompartmental supraretinacular artery pedicled vascularized bone graft has been used successfully with equally promising results. It has become the graft of our choice for the treatment of scaphoid nonunions as it has a longer pedicle and is able to provide a wider arc of rotation that allows easier reach of the volar carpus. The use of rigid internal fixation with screws also permitted early wrist range of motion and shorter periods of immobilization. In this article, we describe our surgical technique of harvesting the 2,3 intercompartmental supraretinacular artery pedicled vascularized bone graft. The anatomy, indications, contraindications, and complications of treatment are also detailed.

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Section: Historical Perspectivementioning

confidence: 99%

2,3 Intercompartmental Supraretinacular Artery Pedicled Vascularized Bone Graft for Scaphoid Nonunions

Tan

Tu²

2013

Techniques in Hand &Amp; Upper Extremity Surgery

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“…At the host–graft interface, vascularized cortical autografts heal quickly, and their remodeling is typically similar to the biological process of normal bone turnover [182]. Because vascularized autografts do not undergo revascularization and resorption, they may offer superior initial strength during the initial 6 weeks post-implantation.…”

Section: Tissue Grafts Of Human Originmentioning

confidence: 99%

“…A brief overview of conventional strategies for treating disfiguration and large composite tissue defects by applying human-derived tissue materials directly illustrates that in addition to autologous tissues, all of the grafts and techniques currently available for clinical application fall short of achieving the complete functional and esthetic replacement of lost/damaged tissues [137,157,178,182,187,218,219,265]. However, close coordination between biologists and surgeons offers a critical step for clinical success, and the implantation of specimens as rapidly as possible may improve the overall engraftment rate.…”

Section: Tissue Grafts Of Human Originmentioning

confidence: 99%

Advancing biomaterials of human origin for tissue engineering

Chen

Liu

2016

Progress in Polymer Science

923

513

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Biomaterials have played an increasingly prominent role in the success of biomedical devices and in the development of tissue engineering, which seeks to unlock the regenerative potential innate to human tissues/organs in a state of deterioration and to restore or reestablish normal bodily function. Advances in our understanding of regenerative biomaterials and their roles in new tissue formation can potentially open a new frontier in the fast-growing field of regenerative medicine. Taking inspiration from the role and multi-component construction of native extracellular matrices (ECMs) for cell accommodation, the synthetic biomaterials produced today routinely incorporate biologically active components to define an artificial in vivo milieu with complex and dynamic interactions that foster and regulate stem cells, similar to the events occurring in a natural cellular microenvironment. The range and degree of biomaterial sophistication have also dramatically increased as more knowledge has accumulated through materials science, matrix biology and tissue engineering. However, achieving clinical translation and commercial success requires regenerative biomaterials to be not only efficacious and safe but also cost-effective and convenient for use and production. Utilizing biomaterials of human origin as building blocks for therapeutic purposes has provided a facilitated approach that closely mimics the critical aspects of natural tissue with regard to its physical and chemical properties for the orchestration of wound healing and tissue regeneration. In addition to directly using tissue transfers and transplants for repair, new applications of human-derived biomaterials are now focusing on the use of naturally occurring biomacromolecules, decellularized ECM scaffolds and autologous preparations rich in growth factors/non-expanded stem cells to either target acceleration/magnification of the body's own repair capacity or use nature's paradigms to create new tissues for restoration. In particular, there is increasing interest in separating ECMs into simplified functional domains and/or biopolymeric assemblies so that these components/constituents can be discretely exploited and manipulated for the production of bioscaffolds and new biomimetic biomaterials. Here, following an overview of tissue auto-/allo-transplantation, we discuss the recent trends and advances as well as the challenges and future directions in the evolution and application of human-derived biomaterials for reconstructive surgery and tissue engineering. In particular, we focus on an exploration of the structural, mechanical, biochemical and biological information present in native human tissue for bioengineering applications and to provide inspiration for the design of future biomaterials.

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“…Implantation of vessels has been shown to induce neovascularization and new bone formation in conventional rabbit and canine autografts 23,25,26 , canine nonvascularized allografts 27 , and dog-to-rabbit nonvascularized xenografts 28 . The method has been applied clinically in the treatment of Kienböck disease 29 , talar osteonecrosis 22,30 , and scaphoid nonunion with osteonecrosis 19,31,32 , and in prefabricated bone free flaps [33][34][35] . It also improves the results of necrotic structural allografts 36 and revascularizes massive structural allografts (intramedullary bone autograft) 37 .…”

mentioning

confidence: 99%