Vascularization of tissue-engineered skeletal muscle constructs

Gholobova, Dacha; Terrie, Lisanne; Gérard, Melanie; Declercq, Heidi; Thorrez, Lieven

doi:10.1016/j.biomaterials.2019.119708

Cited by 68 publications

(56 citation statements)

References 190 publications

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“…Native skeletal muscle is highly vascularized to provide the oxygen and nutrient supply required to support the high metabolic demands induced by muscle contraction. Hypoxia and impaired cell survival typically occur at a diffusion distance of 150-200µm from blood vessels or in culture media and limits tissue-engineered muscle size (Gholobova et al, 2020a). Satellite cell fate and muscle regeneration is also regulated by vasculature (Abou-Khalil et al, 2009, 2010Fu et al, 2015), with 50-80% of satellite cells are in near or direct contact with capillaries (Verma et al, 2018).…”

Section: Vascularization Of Engineered Muscle Tissuesmentioning

confidence: 99%

Tissue-Engineered Skeletal Muscle Models to Study Muscle Function, Plasticity, and Disease

Khodabukus

2021

Front. Physiol.

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Skeletal muscle possesses remarkable plasticity that permits functional adaptations to a wide range of signals such as motor input, exercise, and disease. Small animal models have been pivotal in elucidating the molecular mechanisms regulating skeletal muscle adaptation and plasticity. However, these small animal models fail to accurately model human muscle disease resulting in poor clinical success of therapies. Here, we review the potential of in vitro three-dimensional tissue-engineered skeletal muscle models to study muscle function, plasticity, and disease. First, we discuss the generation and function of in vitro skeletal muscle models. We then discuss the genetic, neural, and hormonal factors regulating skeletal muscle fiber-type in vivo and the ability of current in vitro models to study muscle fiber-type regulation. We also evaluate the potential of these systems to be utilized in a patient-specific manner to accurately model and gain novel insights into diseases such as Duchenne muscular dystrophy (DMD) and volumetric muscle loss. We conclude with a discussion on future developments required for tissue-engineered skeletal muscle models to become more mature, biomimetic, and widely utilized for studying muscle physiology, disease, and clinical use.

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Section: Vascularization Of Engineered Muscle Tissuesmentioning

confidence: 99%

Tissue-Engineered Skeletal Muscle Models to Study Muscle Function, Plasticity, and Disease

Khodabukus

2021

Front. Physiol.

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“…3D printing technology had been used to construct an engineered organ, which enabled the organ to complete the spatial arrangement of cells, the composition of ECM, and the multicellular activity [ 103 , 104 ]. In 3D scaffolds, cancer cells and endothelial cells were co-cultured, a vascular structure could be formed by using microfluidic technology [ 105 ]. In the future, with the rapid development of cancer organoid technology, tumor organoids will be first expected to predict the effectiveness and accuracy of drug responses in vitro [ 106 ].…”

Section: The Deficiency and Prospect Of Cancer Organoid Model For Drumentioning

confidence: 99%

Drug screening model meets cancer organoid technology

Liu

Qin

Huang

et al. 2020

Translational Oncology

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Tumor organoids inherit the genomic and molecular characteristics of the donor tumor, which not only bridge the gap between genome and phenotype but also circumvent the disadvantages such as genetic information change by using 2D cell lines and the mouse-specific tumor evolution in patient-derived xenograft (PDX). So, cancer organoid has been widely applied to preclinical drug evaluation, biomarker identification, biological research, and individualized therapy. Besides, cancer organoid can be preserved, resuscitated, passed infinitely, and mechanically cultured on a chip for drug screening; it has become one of the partial models for low/high-throughput drug screening in the preclinical trial in vitro. Therefore, this review presents the recent developments of tumor organoids for drug screening, which will introduce from four aspects, including the stability/credibility, types, application, deficiency and prospect of the tumor organoids model for drug screening.

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“…The co-culture of muscle and endothelial cells in fibrin-based hydrogels enabled the formation of aligned myofibers and interconnected endothelial networks [ 148 ]. Marcinczyk et al investigated the material properties of laminin-111-incorporated fibrin hydrogels, capability for myogenesis, and response to electromechanical stimulation [ 147 ].…”

Section: Biomaterials For the Transplantation Of Striated Muscle Cellsmentioning

confidence: 99%

Current Strategies for the Regeneration of Skeletal Muscle Tissue

Alarçin

Bal‐Öztürk

Avcı

et al. 2021

IJMS

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Traumatic injuries, tumor resections, and degenerative diseases can damage skeletal muscle and lead to functional impairment and severe disability. Skeletal muscle regeneration is a complex process that depends on various cell types, signaling molecules, architectural cues, and physicochemical properties to be successful. To promote muscle repair and regeneration, various strategies for skeletal muscle tissue engineering have been developed in the last decades. However, there is still a high demand for the development of new methods and materials that promote skeletal muscle repair and functional regeneration to bring approaches closer to therapies in the clinic that structurally and functionally repair muscle. The combination of stem cells, biomaterials, and biomolecules is used to induce skeletal muscle regeneration. In this review, we provide an overview of different cell types used to treat skeletal muscle injury, highlight current strategies in biomaterial-based approaches, the importance of topography for the successful creation of functional striated muscle fibers, and discuss novel methods for muscle regeneration and challenges for their future clinical implementation.

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Vascularization of tissue-engineered skeletal muscle constructs

Cited by 68 publications

References 190 publications

Tissue-Engineered Skeletal Muscle Models to Study Muscle Function, Plasticity, and Disease

Tissue-Engineered Skeletal Muscle Models to Study Muscle Function, Plasticity, and Disease

Drug screening model meets cancer organoid technology

Current Strategies for the Regeneration of Skeletal Muscle Tissue

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