Vascularization of Ossified Cartilage and the Spread of Cancer in the Larynx

Olszewski, E

doi:10.1001/archotol.1976.00780090042003

Cited by 21 publications

(8 citation statements)

References 9 publications

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“…Thyroid cartilage invasion is considered to occur in areas in which cartilage has undergone ossification . In a study by Olszewski, laryngectomy blood vessels were injected with silicone rubber, and the behavior of the vessels was mapped . It was determined that cancer had most commonly spread through neo‐ossified cartilage, with little to no involvement of nonossified avascular cartilage .…”

Section: Discussionmentioning

confidence: 99%

Management of the thyroid gland during total laryngectomy in patients with laryngeal squamous cell carcinoma

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Management of the thyroid gland during total laryngectomy in patients with laryngeal squamous cell carcinoma

et al. 2015

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“…Besides, the ossification of the larynx cartilage is an important factor in the ageing of the human voice (Heinemann, ). As disadvantage of ossification it should be noted that cartilages of the laryngeal skeleton are damaged by laryngeal cancer mainly in ossified and vascularized sites (Olszewski, ; Kirchner, ; Tillmann and Paulsen, ; Paulsen and Tillmann, ). Furthermore, the ossified laryngeal framework is not only destroyed by invading laryngeal cancer cells, but also a target of metastases of primary tumors which prefer bone, such as for example prostatic cancer (Prescher et al, ).…”

Section: Discussionmentioning

confidence: 99%

Special pattern of endochondral ossification in human laryngeal cartilages: X‐ray and light‐microscopic studies on thyroid cartilage

et al. 2014

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Endochondral ossification is a process that also occurs in the skeleton of the larynx. Differences in the ossification mechanism in comparison to growth plates are not understood until now. To get deeper insights into this process, human thyroid cartilage was investigated by the use of X-rays and a series of light-microscopic stainings. A statistical analysis of mineralization was done by scanning areas of mineralized cartilage and of ossification. We detected a special mode of endochondral ossification which differs from the processes in growth plates. Thyroid cartilage ossifies very slowly and in a gender-specific manner. Compared with age-matched women, bone formation in thyroid cartilage of men is significantly higher in the age group 41-60 years. Endochondral ossification is prepared by internal changes of extracellular matrix leading to areas of asbestoid fibers with ingrowing cartilage canals. In contrast to growth plates, bone is deposited on large areas of mineralized cartilage, which appear at the rims of cartilage canals. Furthermore, primary parallel fibered bone was observed which was deposited on woven bone. The predominant bone type is cancellous bone with trabeculae, whereas compact bone with Haversian systems was seldom found. Trabeculae contain a great number of reversal and arresting lines meaning that the former were often reconstructed and that bone formation was arrested and resumed again with advancing age. It is hypothesized that throughout life trabeculae of ossified thyroid cartilage undergo adaptation to different loads due to the use of voice.

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“…No arytenoid cartilage invasion was observed, even with tumors reaching the posterior end of the vocal cords. This might be explained by the late onset of ossification of the arytenoid cartilages and the elastic nature of their apices and the vocal processes [23].…”

Section: Discussionmentioning

confidence: 99%

Expression of c-erb B-2 oncoprotein in cancer of the larynx in relation to invasion of the cartilagenous framework and prognosis

Tantawy

Youins

Hamza

1999

European Archives of Oto-Rhino-Laryngology

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Oncogenes are important cellular genes that in general promote in the normal growth regulatory pathways. The human c-erb B-2 proto-oncogene (HER-2 or neu) encodes a 185 kDa transmembrane putative growth factor receptor of the tyrosine kinase family. This oncogene has been shown to be over expressed and/or amplified in primary carcinoma of the breast, ovary, pancreas and salivary glands. This study was conducted to evaluate a possible link between amplification of c-erb B-2 oncoprotein and cartilage invasion in laryngeal carcinoma. In addition, data concerning overexpression were compared to other clinicopathological parameters as well as clinical outcomes. In all, 34 patients with squamous cell carcinoma of the larynx were studied prospectively. Total laryngectomy specimens were sliced in horizontal sections at 4- to 5-mm intervals. Specimens were preserved in 10% formalin, and histopathological examinations were carried out after embedding tissues in paraffin sections and then staining them with hematoxylin and eosin. Detection of c-erb B-2 oncoprotein overexpression was carried out with a polyclonal antibody and an avidin-biotin kit. The level of c-erb B-2 overexpression was determined using the Quantimet 520 Leica image analyzing system. However, no significant correlation was found between cartilage invasion and clinicopathological parameters and prognosis. Overexpression of c-erb B-2 attained no significant correlation with clinicopathological parameters. In contrast, the correlation of c-erb B-2 overexpression and cartilage invasion was statistically significant (P = 0.034). In general, overexpression of c-erb B-2 oncoprotein was related to the more aggressive tumors with high capability of invading laryngeal cartilages. Patients with +ve c-erb B-2 oncogene had a poor prognosis but this was not statistically significant when compared to the clinical outcomes of patients with the -ve c-erb B-2 oncogene.

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Vascularization of Ossified Cartilage and the Spread of Cancer in the Larynx

Cited by 21 publications

References 9 publications

Management of the thyroid gland during total laryngectomy in patients with laryngeal squamous cell carcinoma

Management of the thyroid gland during total laryngectomy in patients with laryngeal squamous cell carcinoma

Special pattern of endochondral ossification in human laryngeal cartilages: X‐ray and light‐microscopic studies on thyroid cartilage

Expression of c-erb B-2 oncoprotein in cancer of the larynx in relation to invasion of the cartilagenous framework and prognosis

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