Vascularisation of ocular coralline hydroxyapatite implants

Abstract

Abstract. Vascularisation of coralline hydroxyapatite used to replace the enucleated bulb is of critical importance for the uncomplicated implantation of a motility peg connecting the implant with the cosmetic prosthesis. Technetium-99m diphosphopropanedicarboxylic acid (DPD) single-photon emission tomography (SPET) was used to evaluate the rate of vascularisation as well as the time required for completion of vascularisation. Twenty-four patients were enrolled in the study, which was designed to evaluate vascularisation 10 days, 2 months and 4 months after implantation of a coralline implant. Nineteen patients completed the study and the visual impression of the completion of the vascularisation was scored from 0 (no vascularisation) to ++++ (complete vascularisation) for each patient. No tracer accumulation was detected in any patient at the 10-day examination. Increasing vascularisation was demonstrated with time, and full vascularisation of the coralline implant was seen in all but one case by 4 months after implantation. We conclude that vascularisation of ocular coralline hydroxyapatite implants occurs early and is completed by 4 months after implantation in most cases, but should be confirmed at this time by 99mTc-DPD SPET.

Comparison of alloplastic implants for facial bones by scintigraphy and histology: an experimental study

“…Thereafter, scintigraphic imaging of ocular hydroxyapatite implants was used by Perri [16] and Dutton [17]. Menzel et al evaluated the rate of vascularisation of ocular hydroxyapatite implant by scintigraphy [19]. They concluded that vascularisation occurred early and it was completed by 4 months after implantation but they could not demonstrate this histologically.…”

Hydroxylapatitplombenimplantation nach Enukleation — Erfahrungen in 112 Fällen

“…[ 15]. Die spongiöse Struktur mit zahlreichen miteinander verbundenen Kanälchen ermöglicht das Einwachsen von fibrovaskulärem Gewebe, das sich mit unterschiedlichen Methoden radiologisch nachweisen läßt [2,9,25]. Sowohl bei synthetischem als auch bei korallinem Hydroxylapatit wird das Einsprossen von Bindegewebe begleitet von einer milden Fremdkörperriesenzellenreaktion im und an der Oberfläche des Implantates [17,18,231.…”

SPECT-CT Images of an Ocular Coralline Hydroxyapatite Implant Visible on Bone Scintigraphy

“…Indeed, several studies showed that complete vascularization, studied with Tc-99m biphosphonates, appears between 1 and 6 months after surgery. [1][2][3][4][5][6][7][8][9] However, a local malignant lesion or an orbital infection (taking into account a yellow-green discharge from the left eye) could not be definitely ruled out in this patient. For differentiation between normal and abnormal uptake, SPECT-CT (Symbia T2; Siemens) was performed.…”