Vascular α-Adrenergic Function in Congestive Heart Failure

Feng, Qingping; Arnold, J. Malcolm O.

doi:10.1007/978-1-4615-2003-0_4

Cited by 1 publication

(2 citation statements)

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“…In patients with severe heart failure, there is a decreased α 1 ‐adrenoceptor responsiveness in the dorsal hand vein compared with normal controls (Feng & Arnold 1995). The result from heart failure in humans agrees well with the present investigation.…”

Section: Discussionmentioning

confidence: 99%

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Decreased responsiveness of vascular postjunctional α₁‐, α₂‐adrenoceptors and neuropeptide Y1 receptors in rats with heart failure

Feng

Sun

et al. 1999

Acta Physiologica Scandinavica

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Heart failure is associated with increased sympathetic nerve activity. We hypothesized that chronic sympathetic stimulation in heart failure resulted in decreased vascular sympathetic responsiveness. A pithed rat model was employed to evaluate peripheral vascular alpha-adrenoceptor and neuropeptide Y (NPY) receptor responsiveness. Heart failure was induced in Sprague-Dawley rats by coronary artery ligation. Sham operated rats (Sham) served as controls. Two months after this surgical procedure, both heart failure (n = 30) and Sham (n = 30) rats underwent standard pithing procedure. Pressor responses to preganglionic sympathetic nerve stimulation (PNS) and activation of postjunctional alpha1- and alpha2-adrenoceptors as well as Y1 receptors were studied. In response to PNS, cardiac index was similar between heart failure and sham rats (P = n.s.). Mean arterial pressure (MAP) increased in a frequency-dependent fashion after PNS in heart failure rats as well as in control rats. All the agonists used, i.e. the alpha1-adrenoceptor agonist phenylephrine, the alpha2-adrenoceptor agonists clonidine and BHT933 as well as NPY, induced dose-dependent increases in MAP in heart failure and in sham rats. However, in rats with heart failure, the response to all the agonists studied was significantly decreased and the dose response curves were shifted to the right (P < 0.01). We conclude that in vivo vascular response to postjunctional alpha1- and alpha2-adrenoceptors as well as Y1 receptors are decreased in rats with heart failure.

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Section: Discussionmentioning

confidence: 99%

“…With high level of endogenous agonists such as catecholamines, one would expect that vascular adrenergic response is decreased in heart failure. However, data from human heart failure are controversial owing to differences in severity of heart failure patients in the study population and potential influences of drug treatment (Feng & Arnold 1995).…”

mentioning

confidence: 99%

Decreased responsiveness of vascular postjunctional α₁‐, α₂‐adrenoceptors and neuropeptide Y1 receptors in rats with heart failure

Feng

Sun

et al. 1999

Acta Physiologica Scandinavica

View full text Add to dashboard Cite

show abstract

Vascular α-Adrenergic Function in Congestive Heart Failure

Cited by 1 publication

References 69 publications

Decreased responsiveness of vascular postjunctional α₁‐, α₂‐adrenoceptors and neuropeptide Y1 receptors in rats with heart failure

Decreased responsiveness of vascular postjunctional α₁‐, α₂‐adrenoceptors and neuropeptide Y1 receptors in rats with heart failure

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Vascular α-Adrenergic Function in Congestive Heart Failure

Cited by 1 publication

References 69 publications

Decreased responsiveness of vascular postjunctional α1‐, α2‐adrenoceptors and neuropeptide Y1 receptors in rats with heart failure

Decreased responsiveness of vascular postjunctional α1‐, α2‐adrenoceptors and neuropeptide Y1 receptors in rats with heart failure

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Decreased responsiveness of vascular postjunctional α₁‐, α₂‐adrenoceptors and neuropeptide Y1 receptors in rats with heart failure

Decreased responsiveness of vascular postjunctional α₁‐, α₂‐adrenoceptors and neuropeptide Y1 receptors in rats with heart failure