Vascular Tumors of Bone

IJzendoorn, David G.P. van; Bovée, Judith V.M.G.

doi:10.1016/j.path.2017.04.003

Cited by 24 publications

(13 citation statements)

References 71 publications

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“…Fluorescence in situ hybridization (FISH) break-apart probe for FOSB gene rearrangement can be an excellent diagnostic marker as well. The upregulation of FOSB serves as the underlying molecular mechanism of tumorigenesis [6]. The immunohistochemical study of our case was positive for ERG, CD31, AE1/AE3, and FOSB and negative for TFE3, and CAMTA1, consistent with the diagnosis of PMH.…”

Section: Discussionsupporting

confidence: 62%

“…Vascular tumors of bone include hemangioma, epithelioid hemangioma, PMH, epithelioid hemangioendothelioma, and angiosarcoma. Table 1 summarizes the distribution of vascular tumors of bone as reported by van Ijzendoorn and Bovee [6].…”

Section: Discussionmentioning

confidence: 99%

“…The patient's age was in the upper age range in comparison to reported cases of PMH tumors of bone. Histologically, a panel of immunohistochemical markers such as ERG, CD31, and CD34 are helpful to identify endothelial differentiation of vascular tumors [6]. However, the histologic diagnosis of PMH is challenging since vascular differentiation is essentially absent, and CD34 marker is consistently negative.…”

Section: Discussionmentioning

confidence: 99%

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Pseudomyogenic hemangioendothelioma—A case report and review of the literature

Dianat

Yousaf

Murugan

et al. 2019

Radiology Case Reports

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Pseudomyogenic hemangioendothelioma (PMH) of bone is a very rare tumor and frequently presents at multiple locations. PMH is difficult to diagnose by imaging and histopathologic features. Various and partially discordant imaging findings have been reported in case reports and small case series. We report a case of a 63-year-old man with PMH isolated to the sacrum, presenting with chronic intermittent buttock pain that was incidentally identified on imaging for acute pancreatitis. We believe that learning about PMH of bone will help to include this disease in the differential diagnosis of lytic lesions of the sacrum. Becoming aware of the various and sometimes discordant imaging findings of this rare entity is important and helpful for radiologists, pathologists, and orthopedic surgeons.

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Section: Discussionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Pseudomyogenic hemangioendothelioma—A case report and review of the literature

Dianat

Yousaf

Murugan

et al. 2019

Radiology Case Reports

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“…EHE of bones is very rare and accounts for 1% of all primary bone neoplasms [ 6 ]. The long tubular bones are affected most commonly, followed by the spine [ 7 ]. In the lower extremity, the most common locations, in decreasing order for occurrence, are femur, tibia, fibula and the small bones of the feet [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

Recurrent Epithelioid Hemangioendothelioma of Calcaneum: A Case Report of a Rare Tumor

Rustagi

Sen

Prasad

et al. 2021

Cureus

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Epithelioid hemangioendothelioma (EHE) is an uncommon malignant vascular tumor characterized by epithelioid or histiocytoid endothelial appearance. Here we present the case of a 65-year-old female with recurrent EHE of the left calcaneum. The patient had developed soft-tissue swelling over the lateral aspect of the left hindfoot three years ago, which was previously managed by excisional biopsy as per medical records and the histopathological examination (HPE) had revealed an EHE. A year later, she again developed a painful swelling with superficial ulceration over the same region and presented to us. A plain radiograph of the foot showed a soft-tissue swelling with cortical breach over the lateral aspect of calcaneum. MRI revealed a mass encasing peroneus tendons, with extension into the lateral surface of calcaneum. CT angiography revealed a mass eroding the lateral cortex of calcaneum and receiving blood supply from calcaneal branches of peroneal artery. PET-CT scan did not reveal any other primary or metastatic site. Core needle biopsy of calcaneum was suggestive of EHE. Limb salvage was difficult as the tumor was recurrent and involved the skin and the weight-bearing part of the calcaneum. The patient was managed with transtibial amputation. Immunohistochemical (IHC) staining of the excised tissue was positive for CD34, Vimentin, SMA, and Fli-1. The margins were negative for any tumor cells and she did not require any adjuvant therapy. At two years follow-up, she was free of any further recurrence or metastasis. Recurrent tumors of this variety are fast-growing with metastatic potential and may cause mortality. Hence, they need to be managed aggressively.

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“…[1] Long tubular bones are the most commonly affected, followed by the spine. [7] Around 50% of patients present with multicentric tumors. [8] The pathogenesis of EHE is still uncertain.…”

Section: Discussionmentioning

confidence: 99%

Epithelioid hemangioendothelioma of the bone

Chen

Cheng

et al. 2019

Medicine

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Introduction: Epithelioid hemangioendothelioma (EHE) of the bone is a very rare malignant vascular neoplasm, with biologic behavior between that of locally aggressive epithelioid hemangioma and malignant epithelioid angiosarcoma. We report a case of a patient with EHE who underwent bone scintigraphy, try to identify the characteristics of it, to highlight the clinical importance of whole-body bone scintigraphy and single-photon emission computed tomography/computed tomography (SPECT/ CT) in the diagnosis and treatment of EHE. Patient concerns: A 67-year-old man with no history of trauma who reported pain in both lower limbs for 6 months, which had been worsening over the last 20 days. Anteroposterior and lateral radiographs of both lower limbs revealed numerous osteolytic lesions in the tibia and fibula bilaterally. 99m Tc-methylene diphosphonate (MDP) bone scintigraphy demonstrated increased tracer uptake in the pelvic and bilateral lower limb bones. SPECT/CT bone imaging showed numerous osteolytic lesions cluster in the same anatomic region, with high tracer uptake in lesion margins. Diagnosis: EHE of the bone. Interventions: Two months after the diagnosis was confirmed, the patient was rehospitalized. Nonopioid analgesic use had not provided pain relief. Magnetic resonance imaging (MRI) of both thighs showed the bone cortex was destroyed with numerous irregular lesions, and soft-tissue was involved. A second bone scintigraphy did not show any new lesions. He was administrated with recombination human endostatin injection 15 mg ivgtt qd for 14 days, combined with apatinib mesylate tablets 500 mg po qd for 18 days. Outcomes: He was discharged voluntarily and died 2 months later. Conclusion: EHE of the bone is a very rare malignant vascular neoplasm with no specific radiographic imaging features. Whole-body bone scintigraphy, especially SPECT/CT bone imaging, significantly reduces ambiguous diagnoses and is recommended before treatment.

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Vascular Tumors of Bone

Cited by 24 publications

References 71 publications

Pseudomyogenic hemangioendothelioma—A case report and review of the literature

Pseudomyogenic hemangioendothelioma—A case report and review of the literature

Recurrent Epithelioid Hemangioendothelioma of Calcaneum: A Case Report of a Rare Tumor

Epithelioid hemangioendothelioma of the bone

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