Vascular stiffening and endothelial dysfunction in atherosclerosis

Hooglugt, Aukie; Klatt, Olivia; Huveneers, Stephan

doi:10.1097/mol.0000000000000852

Cited by 19 publications

(5 citation statements)

References 107 publications

(141 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Krauss et al (1996) found a significant association between iNPH and arterial hypertension, hypothesizing that arterial hypertension could be involved in the pathogenesis of iNPH [ 18 ]. Atherosclerosis could also play a role as it can increase systolic and pulse pressure via causing arterial stiffness, a fact that can eventually lead to ventricular enlargement [ 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Cerebrospinal Fluid Biomarkers in iNPH: A Narrative Review

et al. 2022

View full text Add to dashboard Cite

Idiopathic normal pressure hydrocephalus (iNPH) is a neurological syndrome characterized by the clinical triad of gait disorder, cognitive impairment and urinary incontinence. It has attracted interest because of the possible reversibility of symptoms, especially with timely treatment. The main pathophysiological theory is based on a vicious circle of disruption in circulation of cerebrospinal fluid (CSF) that leads to the deceleration of its absorption. Data regarding CSF biomarkers in iNPH are contradictory and no definite CSF biomarker profile has been recognized as in Alzheimer’s disease (AD), which often co-exists with iNPH. In this narrative review, we investigated the literature regarding CSF biomarkers in iNPH, both the established biomarkers total tau protein (t-tau), phosphorylated tau protein (p-tau) and amyloid peptide with 42 amino acids (Aβ42), and other molecules, which are being investigated as emerging biomarkers. The majority of studies demonstrate differences in CSF concentrations of Aβ42 and tau-proteins (t-tau and p-tau) among iNPH patients, healthy individuals and patients with AD and vascular dementia. iNPH patients present with lower CSF Aβ42 and p-tau concentrations than healthy individuals and lower t-tau and p-tau concentrations than AD patients. This could prove helpful for improving diagnosis, differential diagnosis and possibly prognosis of iNPH patients.

show abstract

Section: Introductionmentioning

confidence: 99%

Cerebrospinal Fluid Biomarkers in iNPH: A Narrative Review

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Logistic regression analysis in our study identi ed age over 80 as an independent risk factor for AMI, consistent with ndings from various studies that highlight advanced age as a wellestablished predictor of AMI (19,20,(23)(24)(25)(26). The complexity and uncertainty surrounding the mechanism by which advanced age contributes to AMI may be associated with endothelial dysfunction and atherosclerosis, increasing the risk of AMI (27,28). Moreover, patients without AMI were more likely to have Medicaid, private insurance, or self-pay, as opposed to those with AMI (Table 3).…”

Section: Discussionmentioning

confidence: 99%

Risk Factors of Post-Partial Hepatectomy Acute Myocardial Infarction ： A Retrospective Nationwide Inpatient Sample Database Study

Li,

Wang,

Zhou

et al. 2024

Preprint

View full text Add to dashboard Cite

Background The aftermath of partial hepatectomy often results in a severe condition known as acute myocardial infarction (AMI), which may lead to death and frequently necessitates coronary angiography-directed percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG). Despite this, the occurrence and factors associated with AMI following partial hepatectomy have not been comprehensiveky investigated using a nationwide database. Methods This study utilized data from the National Inpatient Sample (NIS) database, covering the years 2015 to 2019, involving 81,735 patients who underwent partial hepatectomy and were categorized into two groups according to the occurrence of AMI. Patient demographics (age, sex, and race), hospital characteristics (type of admission and payer, and bed size, teaching status, and location), length of stay (LOS), total charges during hospitalization, in-hospital mortality, comorbidities, and perioperative complications were analyzed. A multivariate logistic regression analysis was conducted to ascertain independent predictors of acute myocardial infarction following partial hepatectomy. Results A total of 81,735 partial hepatectomies was identified from the National Inpatient Sample, with an overall incidence of in-hospital AMI post partial hepatectomy of 0.8%. Except for 2015, the annual incidence rate of AMI exhibited a downward trend from 2016 to 2019. Patients with AMI after partial hepatectomy were associated with prolonged hospitalization, overall expenses, usage of Medicare, and in-hospital mortality. Factors associated with AMI comprised advanced age (≥ 80 years), multiple comorbidities (n ≥ 6), coronary heart disease, congestive heart failure, coagulopathy, fluid and electrolyte disorders, neurological disorders and paralysis. Furthermore, AMI was associated with cardiac arrest, respiratory failure, acute renal failure, pulmonary embolism, stroke, gastrointestinal hemorrhage, thrombocytopenia, and pneumonia. Conclusion The present study revealed a relatively low occurrence of in-hospital AMI following partial hepatectomy, coupled with unfavorable outcomes. Exploring the risk factors associated with AMI post-partial hepatectomy is essential for optimal treatment and mitigating potential adverse outcomes. Trial registration retrospectively registered

show abstract

“…Further, the model could be used to effectively engineer vascular network in-vitro by studying the role of hydrogel on vascular permeability 53 . The model could also in future be extended to understand the role of ageing on vascular stiffening 54 or the effect of cytoskeletal metabolic memory 55 on cell-cell junctions and thereby permeability. The phenomenological model presented in this article is motivated by the mechanical responses observed during in-vitro experiments.…”

Section: Discussionmentioning

confidence: 99%